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Your search keyword '"Chen, Guo-Ying"' showing total 6 results
Start Over Author "Chen, Guo-Ying" Journal organic letters
6 results on '"Chen, Guo-Ying"'

5. Asymmetric Construction of Functionalized Bicyclic Imides via [3 2] Annulation of MBH Carbonates Catalyzed by Dipeptide-Based Phosphines.

Author

Zhong, Fangrui, Chen, Guo-Ying, Han, Xiaoyu, Yao, Weijun, and Lu, Yixin

Subjects
*IMIDES, *BICYCLIC compounds, *ASYMMETRY (Chemistry), *CARBONATES, *DIPEPTIDES, *CATALYSIS, *PHOSPHINES, *ENANTIOSELECTIVE catalysis, *CHIRALITY
Abstract

A highly enantioselective [3 2] annulation of MBH carbonates and maleimides catalyzed by chiral phosphines has been developed. In the presence of 5 mol % of l-Thr-l-Val-derived phosphine 6, functionalized bicyclic imides were prepared in excellent yields, and with high diastereoselectivities and nearly perfect enantioselectivities. [ABSTRACT FROM AUTHOR]

Published
2012
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6. Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: facile creation of 3-hydroxy-2-oxindoles.

Author

Zhong F, Chen GY, and Lu Y

Subjects
Catalysis, Hydroxylation, Molecular Structure, Oxindoles, Stereoisomerism, Acrylates chemistry, Indoles chemical synthesis, Isatin chemistry
Abstract

The first tertiary amine catalyzed enantioselective Morita-Baylis-Hillman (MBH) reaction of isatins with acrylates has been demonstrated, allowing asymmetric synthesis of biologically significant 3-substituted-3-hydroxy-2-oxindoles in good yields and with excellent enantioselectivities. The C6'-OH group of β-isocupreidine (β-ICD) is believed to facilitate the key proton transfer step in the MBH reaction, via an intramolecular proton relay process.

Published
2011
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