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Your search keyword '"Boezio, Alessandro A."' showing total 4 results
Start Over Author "Boezio, Alessandro A." Journal organic letters
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4. Direct, Regioselective N-Alkylation of 1,3-Azoles.

Author

Chen S, Graceffa RF, and Boezio AA

Subjects
Alkylation, Catalysis, Magnesium chemistry, Molecular Structure, Organometallic Compounds chemistry, Stereoisomerism, Azoles chemistry
Abstract

Regioselective N-alkylation of 1,3-azoles is a valuable transformation. Organomagnesium reagents were discovered to be competent bases to affect regioselective alkylation of various 1,3-azoles. Counterintuitively, substitution selectively occurred at the more sterically hindered nitrogen atom. Numerous examples are provided, on varying 1,3-azole scaffolds, with yields ranging from 25 to 95%.

Published
2016
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