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Your search keyword '"Alison D. Findlay"' showing total 3 results
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3 results on '"Alison D. Findlay"'

1. Synthetic Studies on the Natural Product Myrsinoic Acid F Reveal Biologically Active Analogues

Author

Brett D. Schwartz, Jiri Mikusek, Jeremy Nugent, Jonathan Stuart Foot, Martin G. Banwell, Alison D. Findlay, and Jas S. Ward

Subjects
Biological Products, Natural product, Molecular Structure, 010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Biological activity, Alkenes, 010402 general chemistry, 01 natural sciences, Biochemistry, Non steroidal, 0104 chemical sciences, chemistry.chemical_compound, Myrsinoic acid F, Indometacin, medicine, Animals, Physical and Theoretical Chemistry, Ear edema, medicine.drug, Benzofurans
Abstract

The synthesis of the structure, 1, assigned to the anti-inflammatory natural product myrsinoic acid F is reported together with a means for preparing its Z-isomer 21. While neither of these compounds corresponds to the natural product, both of them are anti-inflammatory agents (as determined using a mouse ear edema assay) with congener 1 being notably more potent than the widely prescribed NSAID indometacin.

Published
2018

2. Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19

Author

Ian Paterson, and Alison D. Findlay, and Gordon J. Florence

Subjects
chemistry.chemical_classification, Glycosylation, Molecular Structure, Alkene, Stereochemistry, Organic Chemistry, Total synthesis, Stereoisomerism, Key features, Rhamnose, Biochemistry, Stereocenter, chemistry.chemical_compound, chemistry, Aldol reaction, Mollusca, Animals, Organic chemistry, Marine Toxins, Physical and Theoretical Chemistry
Abstract

[reaction: see text] A revised configurational assignment for the cytotoxic marine macrolide dolastatin 19 is proposed and validated by total synthesis. Key features of the route include an asymmetric vinylogous aldol reaction to install the isolated C13 stereocenter and (E)-trisubstituted alkene, two sequential 1,4-syn boron-mediated aldol reactions, and a Mukaiyama glycosylation to append the l-rhamnose-derived pyranoside.

Published
2006
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3. A Chemoenzymatic Total Synthesis of (+)-Amabiline.

Author

Alison D. Findlay and Martin G. Banwell

Subjects
*ALKALOID synthesis, *ENZYMES, *CATECHOL, *ENANTIOMERS, *OPTICAL isomers
Abstract

The readily available and enzymatically derived cis-1,2-dihydrocatechol 3has been converted, over 15 steps, into (+)-amabiline, the non-natural enantiomeric form of a crinine-type alkaloid. [ABSTRACT FROM AUTHOR]

Published
2009
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