1. Motualevic Acids A−F, Antimicrobial Acids from the Sponge Siliquariaspongiasp.
- Author
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Jessica L. Keffer, Alberto Plaza, and Carole A. Bewley
- Subjects
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ANTIBACTERIAL agents , *SPONGES (Invertebrates) , *ORGANIC acids , *SEPARATION (Technology) , *CHEMICAL structure , *CARBOXYLIC acids , *SPECTRUM analysis - Abstract
Seven new antibacterials, motualevic acids A−F (1−6) and (4E)-(R)-antazirine (7), have been isolated from the marine sponge Siliquariaspongiasp. and their structures elucidated by spectroscopic methods. Motualevic acids A−D are the first glycyl conjugates of the ω-brominated lipid (E)-14,14-dibromotetradeca-2,13-dienoic acid, and motualevic acid F is the first long-chain 2H-azirine 2-carboxylic acid to be found in nature. Carboxylic acid-containing compounds 1and 6inhibit the growth of Staphylococcus aureusand methicillin-resistant S. aureusat 1.2−10.9 μg/mL. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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