1. Functionalized Cyclobutanes via Heck Cyclization.
- Author
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Anna Innitzer, Lothar Brecker, and Johann Mulzer
- Subjects
- *
ELIMINATION (Mathematics) , *ALGEBRA , *RING formation (Chemistry) , *CHEMICAL reactions - Abstract
Heck-type 4-exo-trigcyclization of linear 2-enol triflate-1,5-hexadienes provides functionalized methylene cyclobutanes. Intramolecular palladium coordination can initiate -hydride elimination leading to 1,2-dimethylene cyclobutane derivatives, which are obtained with high selectivity if substrates having a geminal diphenyl group at Care used. In parallel, formal 5-endo-trigcyclization and -hydride elimination form 1-methylene cyclopent-2-en derivatives. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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