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2. Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates

Author

Samanta, Sadhanendu, Cui, Jin, Otsuka, Yasunari, Watanabe, Takumi, and Shibasaki, Masakatsu

Abstract

The first enantioselective copper-catalyzed conjugate addition of α-substituted benzyl nitriles to alkyl acrylates is described. This protocol allows the direct and 100% atom-economic generation of a nitrile-containing quaternary stereogenic center in a highly enantioselective manner. The practical application of our methodology was demonstrated through the concise formal synthesis of (−)-aphanorphine.

Published
2024
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