1. S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors.
- Author
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Yeh HW, Lin TS, Wang HW, Cheng HW, Liu DZ, and Liang PH
- Subjects
- Animals, Antiviral Agents administration & dosage, Cell Line, Dogs, Humans, Influenza A Virus, H1N1 Subtype physiology, Influenza, Human drug therapy, Influenza, Human virology, Liposomes, Micelles, Oligosaccharides administration & dosage, Orthomyxoviridae Infections drug therapy, Orthomyxoviridae Infections virology, Antiviral Agents chemistry, Antiviral Agents pharmacology, Influenza A Virus, H1N1 Subtype drug effects, Oligosaccharides chemistry, Oligosaccharides pharmacology, Virus Internalization drug effects
- Abstract
An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.
- Published
- 2015
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