1. An efficient synthesis and bioactivity evaluation of oxazole-containing natural hinduchelins A-D and their derivatives.
- Author
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Ke S, Zhang Z, Shi L, Liu M, Fang W, Zhang Y, Wu Z, Wan Z, Long T, and Wang K
- Subjects
- Actinomycetales chemistry, Animals, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Antifungal Agents chemical synthesis, Antifungal Agents chemistry, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Aphids drug effects, Biological Products chemical synthesis, Biological Products chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Drug Screening Assays, Antitumor, Fungi drug effects, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Humans, Insecticides chemical synthesis, Insecticides chemistry, Microbial Sensitivity Tests, Moths, Oxazoles chemical synthesis, Oxazoles chemistry, Anti-Bacterial Agents pharmacology, Antifungal Agents pharmacology, Antineoplastic Agents pharmacology, Biological Products pharmacology, Insecticides pharmacology, Oxazoles pharmacology
- Abstract
Oxazoles are an important class of biologically active metabolites from nature, and exhibit broad biological activities as the lead for drug discovery. Hinduchelins are a class of unusual natural products with an oxazole unit, isolated from Streptoalloteichus hindustanus, and with a potential iron-chelating ability. These compounds are the first identified naturally occurring unusual oxazole derivatives to possess a catechol unit. However, some of these compounds are not abundant in nature, and thus, the efficient syntheses of these compounds are advantageous in exploring their potential applications. This paper reports the efficient synthesis and bio-evaluation of hinduchelins A-D and their derivatives with convenient procedures and high yields.
- Published
- 2019
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