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Start Over Author "Izzo I" Journal organic & biomolecular chemistry
4 results on '"Izzo I"'

4. Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids

Author

Paolo Tecilla, Irene Izzo, Ines Bruno, J. Buirey, F. De Riccardis, G. Della Sala, Massimo Tosolini, Mariacarmela Vaccaro, Rosaria Schettini, Chiara Costabile, Schettini, R., Costabile, C., Della Sala, G., Buirey, J., Tosolini, M., Tecilla, P., Vaccaro, M. C., Bruno, I., De Riccardis, F., and Izzo, I.

Subjects
Supramolecular chemistry, cyclic peptoid, ion transport, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Biochemistry, Peptoids, Hydroxyproline, chemistry.chemical_compound, Biomimetic Materials, Cell Line, Tumor, Humans, Physical and Theoretical Chemistry, Ion transporter, Cell Proliferation, Liposome, 010405 organic chemistry, Sodium, Organic Chemistry, Alkali metal, Combinatorial chemistry, Affinities, 0104 chemical sciences, Monomer, chemistry, Surface modification
Abstract

Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed "submonomer/monomer" approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines.

Published
2018

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