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[Display omitted] • Seabee Gold Operation that hosts Santoy and Fisher yield a similar ore genesis. • Fisher and Santoy deposits host multi-stage system of orogenic gold mineralization. • Early gold mineralization overprinted by main-stage orogenic mineralization. • Mineral chemistry of alteration mineral assemblages similar for Fisher and Santoy. The Seabee Gold Operation, located in northern Saskatchewan, Canada, hosts the Santoy and Seabee gold deposits, as well as the Fisher property; the latter is an important exploration target. This gold mineralization is hosted in rocks of the Pine Lake greenstone belt that is within the Glennie domain of the larger Paleoproterozoic Trans-Hudson orogen. Mineralization is focused within shear zones, including the Santoy shear system that extends south onto the Fisher property. The role of ore-adjacent intrusions, systematics of gold mineralization, and relationship between the mineralization of the properties are largely undefined. In this study, hydrothermally-altered samples from locations along the Santoy shear system, namely the Santoy 7, Santoy Gap, and the Fisher property, were analyzed to identify and compare the mineralogical and geochemical characteristics related to sulfide-gold mineralization and associated alteration. The altered host rocks primarily comprise upper greenschist to lower amphibolite-grade sheared metabasalt to chlorite-hornblende-biotite ± garnet schist, and intrusive rocks dominated by granodiorite and tonalite. These lithologies are cut by similar quartz vein generations and are associated with similar alteration assemblages and mineralization, including (i) syn -late-D 3 "distal" (∼0.4 to 3 m wide) sericite-biotite-chlorite-clinozoisite ± albite, titanite to vein-adjacent coarse-grained diopside-K-feldspar-albite-actinolite ± apatite, titanite calc-silicate alteration, associated with main-stage Py 2a, 2b -Cpy 2 -Po 1 -Au (syn -late-D 3) mineralization; (ii) remobilized, fracture-filling Py 3 -Po 2- Cpy 3 -Au-BiTel (late-D 3) mineralization within the calc-silicate assemblage; and (iii) early colloform Py 1a (pre- syn -D 3) and intrusion-hosted, inclusion-rich Py 1b (pre-D 3). Microprobe analyses reveal similar mineralogical trends between Fisher and Santoy alteration minerals typical of orogenic gold systems. Empirical geothermobarometric calculations of gold-associated vein-adjacent and vein-hosted chlorite and biotite exhibit orogenic-style formation conditions (∼320–330 °C, 3 kbar, ∼9 km depth). As such, these analyses suggest that the Fisher property and Santoy Mine Complex underwent inter-connected, multi-stage hydrothermal processes. These stages comprise (i) a potential early introduction of gold into the system closer to the timing of plutonism (Py 1b magmatic-hydrothermal; pre-D 1) or during the onset of gold mineralization (Py 1a ; orogenic; late-D 2 to early- syn -D 3) during the evolution of the Reindeer zone; (ii) orogenic main-stage mineralization (syn -late-D 3) concurrent with late- to post- collisional deformation throughout the Reindeer zone; and (iii) remobilization during continuous deformation (late-D 3) where elevated cyclical fluid fluxes and higher fracture density at Santoy produced higher-grade mineralization. [ABSTRACT FROM AUTHOR]