1. Periorbital desmoplastic squamous cell carcinoma
- Author
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Michelle T. Sun, Verona E. Botha, Rami H El-Khayat, Kent Chow, Stephen G J Ng, Paul Salmon, and Dinesh Selva
- Subjects
Male ,Pathology ,medicine.medical_specialty ,medicine.medical_treatment ,Malignancy ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Stroma ,medicine ,Humans ,Neoplasm ,030223 otorhinolaryngology ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Neck dissection ,Parotidectomy ,Middle Aged ,Mohs Surgery ,medicine.disease ,Desmoplasia ,stomatognathic diseases ,Ophthalmology ,medicine.anatomical_structure ,Cervical lymph nodes ,Carcinoma, Squamous Cell ,030221 ophthalmology & optometry ,Orbital Neoplasms ,Female ,Radiotherapy, Adjuvant ,Neoplasm Recurrence, Local ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Desmoplasia is the formation of a dense collagenous stroma around a neoplasm. It occurs in a variety of malignancies including squamous cell carcinoma (SCC). While desmoplasia is uncommonly seen in cutaneous SCC, it is an independent risk factor for recurrence and metastasis. We report a case series of desmoplastic SCC in the periorbital region. Seven cases were identified: the median age was 68, four were men. The mean follow-up was 48 months. Two patients (29%) had aggressive local recurrence: one required salvage surgery including orbital exenteration, parotidectomy, and neck dissection to excise involved parotid and cervical lymph nodes; the other required repeat excision and adjuvant radiotherapy. Desmoplastic SCC is an uncommon but highly aggressive subtype. In the periorbital region, due to the high risk of orbital invasion, it is potentially sight and life-threatening.
- Published
- 2018