13 results on '"de Andrade BAB"'
Search Results
2. Immunohistochemistry and RT-PCR as ancillary tools in the diagnosis of acquired oral syphilis.
- Author
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Barreto MEZ, Soares CD, de Andrade MMP, de Oliveira Sales A, Fonseca FP, Abreu LG, Tenório JR, de Arruda JAA, and de Andrade BAB
- Abstract
Objective: To investigate Treponema pallidum detection using immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) assays in acquired oral syphilis (AOS)., Materials and Methods: Thirty-seven paraffin-embedded tissue specimens of AOS (32 secondary and five primary) were analyzed, integrating double-positive serological results with clinicodemographic and histopathological data. T. pallidum presence was semiquantitatively assessed by IHC, while RT-PCR targeted T. pallidum DNA. Sensitivity, specificity, and the area under the curve (AUC) were calculated with 95% confidence intervals (CI)., Results: The study included mostly females (62.2%) with a mean age of 27.1 years. T. pallidum was detected in all samples by IHC, predominantly in the epithelium across all layers (43.2%). RT-PCR identified T. pallidum DNA in 32 cases, with negative results observed in cases of secondary AOS. The AUC for IHC versus disease stage was 62.5% (95% CI: 45.1-77.8), and for RT-PCR, it was 57.8% (95% CI: 40.5-73.8). The AUC comparing IHC to RT-PCR was 83.8% (95% CI: 67.9-93.8)., Conclusion: This study represents the first attempt to evaluate the proposed direct detection algorithm for AOS. IHC and RT-PCR serve as ancillary tools for detecting T. pallidum in both primary and secondary stages of AOS., (© 2024 John Wiley & Sons Ltd.)
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- 2024
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3. Oral solitary fibrous tumors: A collaborative clinicopathologic study of 19 cases.
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Cunha JLS, Cavalcante IL, Barros EF, de Sousa Neto SS, Cavalcante RB, Turatti E, de Mendonça EF, de Albuquerque-Júnior RLC, Anbinder AL, Fragata da Silva D, Duarte IX, Nonaka CFW, Alves PM, de Almeida OP, and de Andrade BAB
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- Humans, Male, Middle Aged, Female, Adult, Aged, Young Adult, STAT6 Transcription Factor analysis, Mouth Mucosa pathology, Mouth Neoplasms pathology, Solitary Fibrous Tumors pathology, Antigens, CD34 analysis
- Abstract
Objective: To report the clinicopathologic features of 19 oral solitary fibrous tumors (SFTs)., Methods: Clinical data were collected from the records of seven pathology services. All cases were re-evaluated by HE staining and confirmed by immunohistochemistry., Results: The series comprised 11 females (57.9%) and 8 males (42.1%), with a mean age of 47.3 ± 14.7 years (range: 22-71 years) and a 1.3:1 female-to-male ratio. Most tumors affected the buccal mucosa (n = 7; 36.8%) and presented clinically as an asymptomatic solitary submucosal well-circumscribed nodule with coloration similar to the oral mucosa. Morphologically, most SFTs (n = 10; 52.6%) exhibited a classic hybrid pattern characterized by a well-circumscribed proliferation of densely cellular areas alternating with hypocellular areas in a variably collagenous vascular stroma. Remnants of accessory salivary glands were observed in two cases (n = 2; 10.5%). All tumors were positive for STAT6 and CD34 (n = 19; 100%). Outcome information was available from 6 patients (31.6%), with clinical follow-up ranging from 6 to 24 months (mean ± SD, 9.5 ± 6.8 months), and none developed local recurrence., Conclusions: Oral SFTs are rare and often clinically misdiagnosed. Pathologists should consider SFT in the differential diagnosis of oral spindle cell tumors. Accurate diagnosis requires careful morphological evaluation supported by immunohistochemical analysis., (© 2023 Wiley Periodicals LLC.)
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- 2024
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4. Characterization of ectopic germinal centers in Sjögren's syndrome (SS) and non-SS non-sicca patients.
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Silva EV, de Andrade BAB, Silveira HA, Rocha EM, Chahud F, Brunaldi MO, Bufalino A, and León JE
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- Humans, Female, Middle Aged, Male, Choristoma pathology, Adult, Sjogren's Syndrome complications, Germinal Center pathology
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- 2024
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5. Acquired oral syphilis: A multicenter study of 339 patients from South America.
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de Andrade BAB, de Arruda JAA, Gilligan G, Piemonte E, Panico R, Molina Ávila I, Pimentel Sola JM, Carmona Lorduy MC, Pupo Marrugo S, Sánchez Tatis AS, Werner LC, Abrahão AC, Agostini M, Buoro L, Israel MS, Freire NA, Lima LA, Abrantes TC, Cunha JLS, Pérez-de-Oliveira ME, Roza ALOC, Vargas PA, Lopes MA, Santos-Silva AR, de Almeida OP, Pontes FSC, Pontes HAR, Rondanelli BM, Villarroel-Dorrego M, Bologna-Molina R, Derderian N, Sánchez-Romero C, Abreu LG, Fonseca FP, Mesquita RA, Gomez RS, Martínez-Flores R, Delgado-Azañero W, Alves ATNN, Lourenço SQC, Coimbra C, Polignano GAC, Assunção Júnior JNR, Souto GR, Souza PEA, Horta MCR, González-Arriagada WA, and Romañach MJ
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- Adult, Brazil epidemiology, Humans, Male, Palate, Hard, Retrospective Studies, Young Adult, Mouth Diseases diagnosis, Mouth Diseases drug therapy, Mouth Diseases epidemiology, Syphilis diagnosis, Syphilis drug therapy, Syphilis epidemiology
- Abstract
Objective: To report the clinicopathologic features of acquired oral syphilis cases in South American countries., Materials and Methods: Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of nontreponemal and treponemal tests were used for diagnosis., Results: The series comprised 339 cases of acquired oral syphilis. Secondary syphilis ranked as the most common stage (86.7%). Lesions were more frequent among males (58.0%) and young adults with a mean age of 33.3 years. Individuals aged 20-29 years were most affected (35.3%). The most commonly involved sites were the tongue (31.6%), lip/labial commissure (25.1%), and hard/soft palate (20.4%). Clinically, acquired oral syphilis usually presented as mucous patches (28.4%), papules (25.7%), and ulcers (18.1%). Skin manifestations occurred in 67.7% of individuals, while lymphadenopathy and fever were observed in 61.3% and 11.6% of all subjects, respectively. Most patients were treated with the benzathine penicillin G antibiotic., Conclusion: This report validates the spread of acquired oral syphilis infection among young adults in South America. Our directives include accessible diagnostic tools for proper disease screening, surveillance, and counselling of affected individuals, especially in low- and middle-income countries., (© 2021 Wiley Periodicals LLC.)
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- 2022
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6. Oral cancer diagnosis during the COVID-19 pandemic in an oral pathology laboratory in Rio de Janeiro, Brazil.
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Abrantes TC, Bezerra KT, Silva CN, Costa LC, Cabral MG, Agostini M, de Andrade BAB, Abrahão AC, and Romañach MJ
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- Brazil epidemiology, Humans, Pandemics, Pathology, Oral, COVID-19, Mouth Neoplasms diagnosis, Mouth Neoplasms epidemiology
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- 2022
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7. Viral enanthema in oral mucosa: A possible diagnostic challenge in the COVID-19 pandemic.
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Rocha BA, Souto GR, Grossmann SMC, de Aguiar MCF, de Andrade BAB, Romañach MJ, and Horta MCR
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- Consensus, Humans, Mouth Mucosa, Pandemics, Prospective Studies, SARS-CoV-2, Spain, COVID-19, Skin Diseases
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- 2021
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8. A Brazilian multicentre study of 2,497 isolated cases of odontogenic keratocysts.
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Schuch LF, de Arruda JAA, Mosconi C, Kirschnick LB, Pinho RFC, Viveiros SK, Abreu LG, do Amaral-Silva GK, da Silva LP, Martins-Chaves RR, Vasconcelos ACU, Gomes APN, Rivero ERC, Martins MD, Rados PV, de Almeida OP, de Andrade BAB, Romañach MJ, Agostini M, de Mendonça EF, Pontes HAR, de Souza LB, Fonseca FP, de Aguiar MCF, de Sousa SCOM, and Mesquita RA
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- Brazil, Humans, Male, Mandible pathology, Retrospective Studies, Young Adult, Odontogenic Cysts pathology, Odontogenic Tumors pathology
- Abstract
We present the frequency of cases of isolated odontogenic keratocysts submitted to microscopic examination at 10 Brazilian referral centres in Oral and Maxillofacial Pathology. In a retrospective (1953-2017) analysis, data on clinicoradiographic features and treatment of these lesions were collected and analysed descriptively. Among the 258,867 cases retrieved, 2,497 (0.96%) were isolated odontogenic keratocysts. In summary, an overview of individuals affected with isolated odontogenic keratocysts is reported herein. This lesion showed predilection for the posterior mandible of young adult men., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
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- 2020
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9. A multicenter study of oral sarcomas in Brazil.
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de Carvalho WRS, de Souza LL, Pontes FSC, Uchôa DCC, Corrêa DL, de Cáceres CVBL, Lopes MA, Santos-Silva AR, Vargas PA, de Andrade BAB, Romañach M, Gomez RS, Costa SFDS, Batista AC, Mendonça EF, Pinto DDS Júnior, Gondak R, da Cruz Perez DE, Nonaka C, Dos Santos JN, Libório-Kimura TN, Câmara J, Ramôa Pires F, de Souza LB, Martins MD, de Almeida OP, Fonseca FP, and Pontes HAR
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- Adolescent, Adult, Aged, Aged, 80 and over, Biopsy, Brazil epidemiology, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Osteosarcoma epidemiology, Retrospective Studies, Sarcoma, Kaposi epidemiology, Young Adult, Mouth Neoplasms epidemiology, Sarcoma epidemiology
- Abstract
Objectives: The aim of this study was to investigate the prevalence of oral sarcomas from geographic regions of Brazil., Materials and Methods: A cross-sectional study was conducted on biopsies obtained from January 2007 to December 2016 at twelve Brazilian oral and maxillofacial pathology centres. Gender, age, evolution time, clinical aspects, tumour location, tumour size at diagnosis, radiographic aspects and histopathological diagnosis were evaluated. Data were analysed using descriptive statistical methods., Results: From 176,537, a total of 200 (0.11%) oral sarcomas were reported, and the most prevalent were osteosarcomas (74 cases; 37%) and Kaposi's sarcomas (52 cases; 26%). Males were more affected than females at a mean age of 32.2 years old (range of 3-87 years). The most common symptoms were swelling¸ localised pain and bleeding at a mean evolution time of 5.14 months (range <1-156 months). The lesions were mostly observed in the mandible (90 cases; 45%), with a mean tumour size of 3.4 cm (range of 0.3-15 cm). Radiographically, the lesions presented a radiolucent aspect showing cortical bone destruction and ill-defined limits., Conclusions: Oral sarcomas are rare lesions with more than 50 described subtypes. Osteosarcomas and Kaposi's sarcomas were the main sarcomas of the oral cavity in Brazil., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
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- 2020
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10. Clinical predictors of malignancy in palatal salivary gland tumors.
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Mariz BALA, do Socorro Queiroz Feio P, Roza ALOC, de Andrade BAB, Agostini M, Romañach MJ, Fonseca FP, Pontes HAR, Ribeiro ACP, Brandão TB, Rocha AC, Vargas PA, Lopes MA, and Santos-Silva AR
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- Adult, Age Distribution, Aged, Aged, 80 and over, Biopsy, Clinical Decision-Making, Female, Humans, Male, Middle Aged, Palate, Hard, Salivary Glands, Minor, Sex Distribution, Palatal Neoplasms pathology, Salivary Gland Neoplasms pathology
- Abstract
Objectives: To establish a predictive clinical index of malignancy risk in palatal salivary gland tumors (PSGT)., Materials and Methods: One hundred cases of PSGT were evaluated. Clinical data were retrieved from the patient's files. Representative clinical photographs of each tumor were evaluated to identify clinical features suggestive of a malignant tumor. Features significantly associated with malignancy were included in a binary logistic regression model., Results: Malignant tumors were more common in the hard palate, in women and in older patients. Features associated with a malignant diagnosis included pain (p = .017), irregular surface (p = .004), bluish/purple coloration (p < .001), ulceration (p = .005), and telangiectasia (p = .015). After multivariate logistic regression, pain (OR: 4.017; 95% CI: 1.198-13.471; p = .024) and color alteration (OR: 7.243; 95% CI: 2.068-25.363; p = .002) were independently associated with malignancy. Including these factors in a predictive index, the proportion of malignant tumors in patients presenting none, one and two factors were 25% (95% CI: 0.13-0.40), 67% (95% CI: 0.48-0.83), and 85% (95% CI: 0.42-0.99), respectively., Conclusion: Pain and color alteration might be independent predictors of malignancy in PSGT, which could support the decision to perform an incisional or excisional biopsy., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
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- 2019
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11. t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.
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de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, Altemani A, Vargas PA, Abreu LG, and Fonseca FP
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- Biomarkers, Tumor analysis, Biomarkers, Tumor genetics, Carcinoma, Adenoid Cystic metabolism, Genes, myb, Head and Neck Neoplasms metabolism, Humans, In Situ Hybridization, Fluorescence, NFI Transcription Factors, Prevalence, Prognosis, Reverse Transcriptase Polymerase Chain Reaction, Carcinoma, Adenoid Cystic genetics, Head and Neck Neoplasms genetics, Neoplasm Recurrence, Local genetics, Oncogene Proteins, Fusion genetics
- Abstract
The presence of a translocation involving MYB and NFIB genes have been described in adenoid cystic carcinoma (AdCC) from different anatomical regions. However, the exact frequency of this genetic event and its prognostic impact for patient survival remain obscure. The aim of this study was to carry out a systematic review to address the prevalence and the prognostic potential of t(6;9)(MYB-NFIB) in head and neck AdCC. Quantitative analysis was done to determine the prevalence of the translocation. A total of 1,107 articles were initially retrieved with 36 remaining for data extraction. The prevalence of t(6;9)(MYB-NFIB) varied significantly (16%-100%), especially due to methodological heterogeneity among studies. A total of 11 studies attempted to determine the prognostic importance of the translocation, but no study found any significant association with survival rates; only three studies observed a significant association with age, sex, tumour location and the presence of recurrences and metastases. The prevalence of t(6;9)(MYB-NFIB) in head and neck AdCC varies according to the laboratorial methods used, and the best evidence available demonstrates that t(6;9)(MYB-NFIB) does not seem to be a prognostic determinant., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
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- 2019
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12. Calcifying epithelial odontogenic tumours: Collaborative study of 32 cases and review of literature.
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de Arruda JAA, Abreu LG, Silva LVO, Schuch LF, Monteiro JLGC, Arantes DAC, da Costa AAS, Nóbrega KHS, Vasconcelos ACU, de Andrade BAB, Romañach MJ, Sobral APV, Rivero ERC, da Silva TA, Batista AC, and Mesquita RA
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- Brazil, Female, Humans, Male, Mandible pathology, Maxilla pathology, Odontogenic Tumors diagnosis, Skin Neoplasms diagnosis
- Abstract
Objectives: To analyse the occurrence of calcifying epithelial odontogenic tumours (CEOT) based on biopsy records from different Brazilian geographic regions and to contrast the data with a review of the literature., Materials and Methods: A 2-step study was conducted. Step 1 consisted of a collaborative study of biopsies obtained from 1953 to 2017 at six Brazilian oral and maxillofacial pathology centres. Evaluation of 86,268 biopsy records was performed. Demographic and histopathological diagnosis data were assessed. In Step 2, a review of the literature of case reports and cases series of CEOT identified across five electronic databases was conducted., Results: In the collaborative study, 32 cases of CEOT were evaluated. This figure represented 0.03% of the oral and maxillofacial lesions and 1.7% of all odontogenic tumours across the centres. Women in the fourth decade of life were more affected. CEOT occurred more in the mandible than in the maxilla (ratio 1.9:1). The review of the literature showed that Asian individuals were more affected by this neoplasm., Conclusions: Useful knowledge on the epidemiology, treatment and follow-up of CEOT has been provided. Demographic data and clinical features of the cases presented in this collaborative study were quite similar to those of studies reported worldwide., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
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- 2019
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13. A multicentre study of 268 cases of calcifying odontogenic cysts and a literature review.
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de Arruda JAA, Schuch LF, Abreu LG, Silva LVO, Monteiro JLG, Pinho RF, Silva LP, de Sousa SC, de Andrade BAB, Romañach MJ, de Qc Lourenço S, Batista AC, de Mendonça EF, Martins MD, Rados PV, Rivero ER, de Souza LB, Pinheiro MDG, Gomes APN, Vasconcelos ACU, Sobral APV, and Mesquita RA
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- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Brazil epidemiology, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Odontogenic Cyst, Calcifying pathology, Prevalence, Retrospective Studies, Sex Factors, Young Adult, Odontogenic Cyst, Calcifying epidemiology
- Abstract
Objectives: To investigate the frequency of calcifying odontogenic cysts (COCs) that have been submitted for microscopic examination from representative geographic regions of Brazil and to compare it with literature data., Materials and Methods: A retrospective study was conducted on biopsies obtained from 1953 to 2016 at 10 Brazilian oral and maxillofacial pathology centres. A total of 198,350 biopsy specimens were analysed. Demographic data and histopathological diagnosis were evaluated descriptively and statistically. In addition, a literature review of case series was carried out in four electronic databases., Results: A total of 268 cases of COC were surveyed, representing 0.1% of the oral lesions at the centres studied. Female patients in their second decade of life and the maxilla were more affected. The mean lesion size of symptomatic individuals was larger than that of cases without symptoms (p = 0.026). The literature review showed a higher frequency in Asia and Europe, mainly affecting men in the third decade of life., Conclusions: COC is a rare lesion. Novel data on the clinicopathological features of 268 cases have been added to the literature. Data regarding gender and age of the Brazilian patients reported herein contrast with findings of case series and retrospective studies reported elsewhere., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
- Published
- 2018
- Full Text
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