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The results of identifying the vaccinia virus with the use of nanowire biosensors manufactured on the basis of silicon-on-insulator (SOI) films were presented. In our experiments, the vaccinia virus, the LIVP strain from the collection of the State Research Center of Virology and Biotechnology VECTOR of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, and the rabbit blood serum containing specific polyclonal antibodies to the vaccinia virus were used. As shown by our studies, the polyvalent blood serum was electrically neutral at the sensor surface–viral suspension phase interface, the vaccinia virus was positively charged, and polyvalent blood serum–vaccinia virus vaccine complexes had a negative effective charge.

Nanowire SOI biosensors are used to detect the Ebola virus VP40 protein by identifying its immune complexes with specific monoclonal antibodies (MCAs). It is shown that the reaction of specific interaction between VP40 and MCAs causes a more pronounced biosensor response than direct adsorption of VP40 or antibodies to their surface. The formation of antigen — antibody complexes leads to the accumulation of a negative charge on the biosensor surface. The protein and protein — antibody complexes are detected in real time (∼200–300 s per test sample).

A method for forming p-n-diode based silicon electro-optic modulators using local oxidation is tested. It is shown that the local oxidation of silicon allows forming a rib waveguide as a smoothed trapezoid, in contrast to the classical technique of creating a rib waveguide by plasma-chemical etching. The main advantages of the approach used are described: controllability and reproducibility of critical design parameters of the modulators (width and height of the waveguide rib), low surface roughness, and the possibility of using approaches to forming a modulating p-n-diode of combined type in a rib waveguide, which are standard for planar technologies.