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Recently, we developed a time-domain diffuse correlation spectroscopy (TD-DCS) method for neurovascular sensing with higher brain sensitivity. In this paper, laser pulse shaping was designed and demonstrated for TD-DCS at 1064 nm. A quantum superconducting nanowire single-photon detector (SNSPD) with high photon detection efficiency (PDE) and low jitter collects the back-scattered light from the brain. The presented approach is the first step towards scaling up a full fiber optic cap with 96 source channels and 192 custom-made single-photon detectors which will cover most of an adult head.

Non-invasive monitoring of cerebral blood flow at the bedside using diffuse correlation spectroscopy is being investigated as a potential tool to improve brain health outcomes after surgery. In this work we characterize the performance of diffuse correlation spectroscopy measurements in assessing cerebral blood flow in the presence of systemic physiology interference through measurements on several healthy volunteers during CO2 inhalation. We report group averaged responses and the role of multi-layer models in increasing the accuracy of CBF estimates. We compare optical blood flow recordings with transcranial Doppler ultrasound and MRI ASL data.