1. The Definition, Rationale, and Effects of Thresholding in OCT Angiography
- Author
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Andreas Maier, Nadia K. Waheed, Lennart Husvogt, Ricardo N. Louzada, Jay S. Duker, Stefan B Ploner, Eric M. Moult, ByungKun Lee, Eduardo A. Novais, James G. Fujimoto, Sabin Dang, Emily Cole, Julia Schottenhamml, WooJhon Choi, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, and Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
- Subjects
medicine.medical_specialty ,genetic structures ,business.industry ,Outcome measures ,01 natural sciences ,Thresholding ,eye diseases ,Article ,010309 optics ,Geographic atrophy ,03 medical and health sciences ,Ophthalmology ,0302 clinical medicine ,Oct angiography ,0103 physical sciences ,030221 ophthalmology & optometry ,medicine ,sense organs ,business - Abstract
PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed. MAIN OUTCOME MEASURES: A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level. RESULTS: Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal. CONCLUSIONS: Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images., Macula Vision Research Foundation, National Institutes of Health (U.S.) (NIH R01-EY011289-29A), National Institutes of Health (U.S.) (R44-EY022864), National Institutes of Health (U.S.) (R01-CA075289-16), United States. Air Force. Office of Scientific Research (AFOSR FA9550-15-1-0473), United States. Air Force. Office of Scientific Research (FA9550-12-1-0499), Praevium Research Inc., Massachusetts Lions Clubs, Samsung (Firm) (Scholarship)
- Published
- 2017