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21 results on '"Midena, Edoardo"'

1. Incidence of Retinoblastoma Has Increased: Results from 40 European Countries

Author

Stacey, Andrew W., primary, Bowman, Richard, additional, Foster, Allen, additional, Kivelä, Tero T., additional, Munier, Francis L., additional, Cassoux, Nathalie, additional, Fabian, Ido Didi, additional, Harby, Lamis Al, additional, Portabella, Silvia Alarcón, additional, Alia, Donjeta B., additional, All-Eriksson, Charlotta, additional, Antonino, Romanzo, additional, Astbury, Nicholas J., additional, Balaguer, Julia, additional, Balwierz, Walentyna, additional, Barranco, Honorio, additional, Bascaran, Covadonga, additional, Popovic, Maja Beck, additional, Biewald, Eva M., additional, Bobrova, Nadia, additional, Bornfeld, Norbert, additional, Brichard, Bénédicte G., additional, Blum, Sharon, additional, Capra, Michael, additional, Castela, Guilherme, additional, Català-Mora, Jaume, additional, Chantada, Guillermo L., additional, Chernodrinska, Violeta S., additional, Cieslik, Krzysztof, additional, Comsa, Codruta, additional, Correa Llano, Maria G., additional, Csóka, Monika, additional, De Potter, Patrick, additional, Desjardins, Laurence, additional, Dragomir, Monica D., additional, Fernández-Teijeiro, Ana, additional, Aldana, David García, additional, Gregersen, Pernille A., additional, Gomel, Nir, additional, Hadjistilianou, Theodora, additional, Hederova, Stanislava, additional, Hummlen, Marlies, additional, Husakova, Kristina, additional, Ida, Russo, additional, Ilic, Vesna R., additional, Jenkinson, Helen, additional, Kapelushnik, Noa, additional, Kardava, Tamar, additional, Keren-Froim, Naama, additional, Kepak, Tomas, additional, Khotenashvili, Zaza, additional, Klett, Artur, additional, Krivaitiene, Dalia, additional, Latinović, Slobodanka, additional, Lumbroso, Livia, additional, Lysytsia, Lesia, additional, Maka, Erika, additional, Begue, Nieves Martín, additional, Midena, Edoardo, additional, Moll, Annette C., additional, Murgoi, Gabriela, additional, Naumenko, Larisa, additional, Neroev, Vladimir, additional, Nikitovic, Marina, additional, Olechowski, Andrzej, additional, Papyan, Ruzanna, additional, Parrozzani, Raffaele, additional, Parulekar, Manoj V., additional, Pawinska-Wasikowska, Katarzyna, additional, Perić, Sanja, additional, Pochop, Pavel, additional, Polyakov, Vladimir G., additional, Reddy, M. Ashwin, additional, Ritter-Sovinz, Petra, additional, Saakyan, Svetlana, additional, Sagoo, Mandeep S., additional, San Román Pacheco, Sonsoles, additional, Seregard, Stefan, additional, Silva, Sónia, additional, Sorochynska, Tetyana, additional, Stathopoulos, Christina, additional, Kranjc, Branka Stirn, additional, Svojgr, Karel, additional, Tamamyan, Gevorg, additional, Tandili, Alketa, additional, Tateshi, Bekim, additional, Pompe, Manca Tekavcic, additional, Urbak, Steen F., additional, Ushakova, Tatiana L., additional, Valeina, Sandra, additional, van Hoefen Wijsard, Milo, additional, Veleva-Krasteva, Nevyana V., additional, Viksnins, Maris, additional, Wackernagel, Werner, additional, Dod, Charlotte Wolley, additional, Yarovaya, Vera A., additional, Yarovoy, Andrey A., additional, Zhilyaeva, Katsiaryna, additional, and Zondervan, Marcia, additional

Published
2021
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3. A Collaborative Retrospective Study on the Efficacy and Safety of Intravitreal Dexamethasone Implant (Ozurdex) in Patients with Diabetic Macular Edema

Author

Rosenblatt, Amir, primary, Udaondo, Patricia, additional, Cunha-Vaz, José, additional, Sivaprasad, Sobha, additional, Bandello, Francesco, additional, Lanzetta, Paolo, additional, Kodjikian, Laurent, additional, Goldstein, Michaella, additional, Habot-Wilner, Zohar, additional, Loewenstein, Anat, additional, Rosenblatt, Amir, additional, Escobar, Jose Juan, additional, Menon, Geeta, additional, Corcostegui, Borja, additional, Eriksson, Urban, additional, Boixadera, Anna, additional, Sararols, Laura, additional, Guigou, Sebastien, additional, Varano, Monica, additional, Figueira, João, additional, Pollack, Ayalla, additional, Massin, Pascale, additional, Carpineto, Paolo, additional, Recchimurzo, Nicola, additional, Matonti, Frederic, additional, Kinnunen, Kati, additional, Coscas, Florence, additional, Midena, Edoardo, additional, Nascimento, João, additional, Armada, Felix, additional, Sorkin, Nir, additional, and Habot- Wilner, Zohar, additional

Published
2020
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4. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration

Author

Colijn, Johanna M., primary, den Hollander, Anneke I., additional, Demirkan, Ayse, additional, Cougnard-Grégoire, Audrey, additional, Verzijden, Timo, additional, Kersten, Eveline, additional, Meester-Smoor, Magda A., additional, Merle, Benedicte M.J., additional, Papageorgiou, Grigorios, additional, Ahmad, Shahzad, additional, Mulder, Monique T., additional, Costa, Miguel Angelo, additional, Benlian, Pascale, additional, Bertelsen, Geir, additional, Bron, Alain M., additional, Claes, Birte, additional, Creuzot-Garcher, Catherine, additional, Erke, Maja Gran, additional, Fauser, Sascha, additional, Foster, Paul J., additional, Hammond, Christopher J., additional, Hense, Hans-Werner, additional, Hoyng, Carel B., additional, Khawaja, Anthony P., additional, Korobelnik, Jean-Francois, additional, Piermarocchi, Stefano, additional, Segato, Tatiana, additional, Silva, Rufino, additional, Souied, Eric H., additional, Williams, Katie M., additional, van Duijn, Cornelia M., additional, Delcourt, Cécile, additional, Klaver, Caroline C.W., additional, Acar, Niyazi, additional, Altay, Lebriz, additional, Anastosopoulos, Eleftherios, additional, Azuara-Blanco, Augusto, additional, Berendschot, Tos, additional, Bergen, Arthur, additional, Binquet, Christine, additional, Bird, Alan, additional, Bobak, Martin, additional, Larsen, Morten Bøgelund, additional, Boon, Camiel, additional, Bourne, Rupert, additional, Brétillon, Lionel, additional, Broe, Rebecca, additional, Bron, Alain, additional, Buitendijk, Gabrielle, additional, Cachulo, Maria Luz, additional, Capuano, Vittorio, additional, Carrière, Isabelle, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chang, Petrus, additional, Colijn, Johanna, additional, Cree, Angela, additional, Cumberland, Phillippa, additional, Cunha-Vaz, José, additional, Daien, Vincent, additional, De Jong, Eiko, additional, Deak, Gabor, additional, Delyfer, Marie-Noëlle, additional, Hollander, Anneke den, additional, Dietzel, Martha, additional, Faria, Pedro, additional, Farinha, Claudia, additional, Finger, Robert, additional, Fletcher, Astrid, additional, Foster, Paul, additional, Founti, Panayiota, additional, Gorgels, Theo, additional, Grauslund, Jakob, additional, Grus, Franz, additional, Hammond, Christopher, additional, Heesterbeek, Thomas, additional, Hermann, Manuel, additional, Hoehn, René, additional, Hogg, Ruth, additional, Holz, Frank, additional, Hoyng, Carel, additional, Jansonius, Nomdo, additional, Janssen, Sarah, additional, de Jong, Eiko, additional, Khawaja, Anthony, additional, Klaver, Caroline, additional, Korobelnik, Jean-François, additional, Lamparter, Julia, additional, Le Goff, Mélanie, additional, Lehtimäki, Terho, additional, Leung, Irene, additional, Lotery, Andrew, additional, Mauschitz, Matthias, additional, Meester, Magda, additional, Merle, Bénédicte, additional, Meyer zu Westrup, Verena, additional, Midena, Edoardo, additional, Miotto, Stefania, additional, Mirshahi, Alireza, additional, Mohan-Saïd, Sadek, additional, Mueller, Michael, additional, Muldrew, Alyson, additional, Murta, Joaquim, additional, Nickels, Stefan, additional, Nunes, Sandrina, additional, Owen, Christopher, additional, Peto, Tunde, additional, Pfeiffer, Norbert, additional, Prokofyeva, Elena, additional, Rahi, Jugnoo, additional, Raitakari, Olli, additional, Rauscher, Franziska, additional, Ribeiro, Luisa, additional, Rougier, Marie-Bénédicte, additional, Rudnicka, Alicja, additional, Sahel, José, additional, Salonikiou, Aggeliki, additional, Sanchez, Clarisa, additional, Schick, Tina, additional, Schmitz-Valckenberg, Steffen, additional, Schuster, Alexander, additional, Schweitzer, Cédric, additional, Shehata, Jasmin, additional, Silvestri, Giuliana, additional, Simader, Christian, additional, Souied, Eric, additional, Speckauskas, Martynas, additional, Springelkamp, Henriet, additional, Tapp, Robyn, additional, Topouzis, Fotis, additional, van Leeuwen, Elisa, additional, Verhoeven, Virginie, additional, Vingerling, Hans, additional, Von Hanno, Therese, additional, Williams, Katie, additional, Wolfram, Christian, additional, Yip, Jennifer, additional, Zerbib, Jennyfer, additional, Ajana, Soufiane, additional, Arango-Gonzalez, Blanca, additional, Arndt, Verena, additional, Bhatia, Vaibhav, additional, Bhattacharya, Shomi S., additional, Biarnés, Marc, additional, Borrell, Anna, additional, Bühren, Sebastian, additional, Calado, Sofia M., additional, Colijn, Johanna M., additional, Dammeier, Sascha, additional, de Jong, Eiko K., additional, De la Cerda, Berta, additional, Diaz-Corrales, Francisco J., additional, Diether, Sigrid, additional, Emri, Eszter, additional, Endermann, Tanja, additional, Ferraro, Lucia L., additional, Garcia, Míriam, additional, Heesterbeek, Thomas J., additional, Honisch, Sabina, additional, Kilger, Ellen, additional, Langen, Hanno, additional, Lengyel, Imre, additional, Luthert, Phil, additional, Maugeais, Cyrille, additional, Meester-Smoor, Magda, additional, Merle Inserm, Bénédicte M.J., additional, Monés, Jordi, additional, Nogoceke, Everson, additional, Pool, Frances M., additional, Rodríguez, Eduardo, additional, Ueffing, Marius, additional, Ulrich Bartz-Schmidt, Karl U., additional, van Leeuwen, Elisabeth M., additional, and Zumbansen, Markus, additional

Published
2019
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5. Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Author

Mauschitz, Matthias M., primary, Bonnemaijer, Pieter W.M., additional, Diers, Kersten, additional, Rauscher, Franziska G., additional, Elze, Tobias, additional, Engel, Christoph, additional, Loeffler, Markus, additional, Colijn, Johanna Maria, additional, Ikram, M. Arfan, additional, Vingerling, Johannes R., additional, Williams, Katie M., additional, Hammond, Christopher J., additional, Creuzot-Garcher, Catherine, additional, Bron, Alain M., additional, Silva, Rufino, additional, Nunes, Sandrina, additional, Delcourt, Cécile, additional, Cougnard-Grégoire, Audrey, additional, Holz, Frank G., additional, Klaver, Caroline C.W., additional, Breteler, Monique M.B., additional, Finger, Robert P., additional, Acar, Niyazi, additional, Anastosopoulos, Eleftherios, additional, Azuara-Blanco, Augusto, additional, Berendschot, Tos, additional, Bergen, Arthur, additional, Bertelsen, Geir, additional, Binquet, Christine, additional, Bird, Alan, additional, Bobak, Martin, additional, Larsen, Morten Bøgelund, additional, Boon, Camiel, additional, Bourne, Rupert, additional, Brétillon, Lionel, additional, Broe, Rebecca, additional, Bron, Alain, additional, Buitendijk, Gabrielle, additional, Cachulo, Maria Luz, additional, Capuano, Vittorio, additional, Carrière, Isabelle, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chang, Petrus, additional, Colijn, Johanna, additional, Cree, Angela, additional, Cumberland, Phillippa, additional, Cunha-Vaz, José, additional, Daien, Vincent, additional, De Jong, Eiko, additional, Deak, Gabor, additional, Delyfer, Marie-Noëlle, additional, Hollander, Anneke den, additional, Dietzel, Martha, additional, Erke, Maja Gran, additional, Faria, Pedro, additional, Farinha, Claudia, additional, Fauser, Sascha, additional, Finger, Robert, additional, Fletcher, Astrid, additional, Foster, Paul, additional, Founti, Panayiota, additional, Gorgels, Theo, additional, Grauslund, Jakob, additional, Grus, Franz, additional, Hammond, Christopher, additional, Hense, Hans-Werner, additional, Hermann, Manuel, additional, Hoehn, René, additional, Hogg, Ruth, additional, Holz, Frank, additional, Hoyng, Carel, additional, Jansonius, Nomdo, additional, Janssen, Sarah, additional, Kersten, Eveline, additional, Khawaja, Anthony, additional, Klaver, Caroline, additional, Korobelnik, Jean-François, additional, Lamparter, Julia, additional, Le Goff, Mélanie, additional, Lechanteur, Yara, additional, Lehtimäki, Terho, additional, Leung, Irene, additional, Lotery, Andrew, additional, Mauschitz, Matthias, additional, Meester, Magda, additional, Merle, Bénédicte, additional, Meyer zu Westrup, Verena, additional, Midena, Edoardo, additional, Miotto, Stefania, additional, Mirshahi, Alireza, additional, Mohan-Saïd, Sadek, additional, Mueller, Michael, additional, Muldrew, Alyson, additional, Murta, Joaquim, additional, Nickels, Stefan, additional, Owen, Christopher, additional, Peto, Tunde, additional, Pfeiffer, Norbert, additional, Piermarocchi, Stefano, additional, Prokofyeva, Elena, additional, Rahi, Jugnoo, additional, Raitakari, Olli, additional, Rauscher, Franziska, additional, Ribeiro, Luisa, additional, Rougier, Marie-Bénédicte, additional, Rudnicka, Alicja, additional, Sahel, José, additional, Salonikiou, Aggeliki, additional, Sanchez, Clarisa, additional, Schmitz-Valckenberg, Steffen, additional, Schuster, Alexander, additional, Schweitzer, Cédric, additional, Segato, Tatiana, additional, Shehata, Jasmin, additional, Silvestri, Giuliana, additional, Simader, Christian, additional, Souied, Eric, additional, Speckauskas, Martynas, additional, Springelkamp, Henriet, additional, Tapp, Robyn, additional, Topouzis, Fotis, additional, van Leeuwen, Elisa, additional, Verhoeven, Virginie, additional, Verzijden, Timo, additional, Von Hanno, Therese, additional, Wiedemann, Peter, additional, Williams, Katie, additional, Wolfram, Christian, additional, Yip, Jennifer, additional, and Zerbib, Jennyfer, additional

Published
2018
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6. The Decreasing Prevalence of Nonrefractive Visual Impairment in Older Europeans

Author

Delcourt, Cécile, primary, Le Goff, Mélanie, additional, von Hanno, Therese, additional, Mirshahi, Alireza, additional, Khawaja, Anthony P., additional, Verhoeven, Virginie J.M., additional, Hogg, Ruth E., additional, Anastosopoulos, Eleftherios, additional, Cachulo, Maria Luz, additional, Höhn, René, additional, Wolfram, Christian, additional, Bron, Alain, additional, Miotto, Stefania, additional, Carrière, Isabelle, additional, Colijn, Johanna M., additional, Buitendijk, Gabriëlle H.S., additional, Evans, Jennifer, additional, Nitsch, Dorothea, additional, Founti, Panayiota, additional, Yip, Jennifer L.Y., additional, Pfeiffer, Norbert, additional, Creuzot-Garcher, Catherine, additional, Silva, Rufino, additional, Piermarocchi, Stefano, additional, Topouzis, Fotis, additional, Bertelsen, Geir, additional, Foster, Paul J., additional, Fletcher, Astrid, additional, Klaver, Caroline C.W., additional, Korobelnik, Jean-François, additional, Acar, Niyazi, additional, Azuara-Blanco, Augusto, additional, Berendschot, Tos, additional, Bergen, Arthur, additional, Binquet, Christine, additional, Bird, Alan, additional, Bobak, Martin, additional, Boon, Camiel, additional, Brétillon, Lionel, additional, Broe, Rebecca, additional, Buitendijk, Gabrielle, additional, Capuano, Vittorio, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chang, Petrus, additional, Colijn, Johanna, additional, Cougnard-Grégoire, Audrey, additional, Cree, Angela, additional, Cumberland, Phillippa, additional, Cunha-Vaz, José, additional, Daien, Vincent, additional, De Jong, Eiko, additional, Deak, Gabor, additional, Delcourt, Cécile, additional, Delyfer, Marie-Noëlle, additional, den Hollander, Anneke, additional, Dietzel, Martha, additional, Erke, Maja Gran, additional, Faria, Pedro, additional, Farinha, Claudia, additional, Fauser, Sascha, additional, Finger, Robert, additional, Foster, Paul, additional, Gorgels, Theo, additional, Grauslund, Jakob, additional, Grus, Franz, additional, Hammond, Christopher, additional, Hansen, Morten, additional, Helmer, Catherine, additional, Hense, Hans-Werner, additional, Hermann, Manuel, additional, Hoehn, René, additional, Hogg, Ruth, additional, Holz, Frank, additional, Hoyng, Carel, additional, Jansonius, Nomdo, additional, Janssen, Sarah, additional, Kersten, Eveline, additional, Khawaja, Anthony, additional, Klaver, Caroline, additional, Lamparter, Julia, additional, Lechanteur, Yara, additional, Lehtimäki, Terho, additional, Leung, Irene, additional, Lotery, Andrew, additional, Mauschitz, Matthias, additional, Meester, Magda, additional, Merle, Bénédicte, additional, Meyer zu Westrup, Verena, additional, Midena, Edoardo, additional, Mohan-Saïd, Sadek, additional, Mueller, Michael, additional, Muldrew, Alyson, additional, Murta, Joaquim, additional, Nickels, Stefan, additional, Nunes, Sandrina, additional, Owen, Christopher, additional, Peto, Tunde, additional, Prokofyeva, Elena, additional, Rahi, Jugnoo, additional, Raitakari, Olli, additional, Rauscher, Franziska, additional, Ribeiro, Luisa, additional, Rougier, Marie-Bénédicte, additional, Rudnicka, Alicja, additional, Sahel, José, additional, Salonikiou, Aggeliki, additional, Sanchez, Clarisa, additional, Schmitz-Valckenberg, Steffen, additional, Schouten, Johannes, additional, Schuster, Alexander, additional, Schweitzer, Cédric, additional, Segato, Tatiana, additional, Shehata, Jasmin, additional, Silvestri, Giuliana, additional, Simader, Christian, additional, Souied, Eric, additional, Speckauskas, Martynas, additional, Springelkamp, Henriet, additional, Tapp, Robyn, additional, van Leeuwen, Elisa, additional, Verhoeven, Virginie, additional, Verzijden, Timo, additional, Von Hanno, Therese, additional, Vujosevic, Stela, additional, Wiedemann, Peter, additional, Williams, Katie, additional, Yip, Jennifer, additional, and Zerbib, Jennyfer, additional

Published
2018
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7. Ranibizumab Plus Panretinal Photocoagulation versus Panretinal Photocoagulation Alone for High-Risk Proliferative Diabetic Retinopathy (PROTEUS Study)

Author

Figueira, João, primary, Fletcher, Emily, additional, Massin, Pascale, additional, Silva, Rufino, additional, Bandello, Francesco, additional, Midena, Edoardo, additional, Varano, Monica, additional, Sivaprasad, Sobha, additional, Eleftheriadis, Haralabos, additional, Menon, Geeta, additional, Amaro, Miguel, additional, Ayello Scheer, Sarah, additional, Creuzot-Garcher, Catherine, additional, Nascimento, João, additional, Alves, Dalila, additional, Nunes, Sandrina, additional, Lobo, Conceição, additional, and Cunha-Vaz, José, additional

Published
2018
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8. Prevalence of Age-Related Macular Degeneration in Europe

Author

Colijn, Johanna M., primary, Buitendijk, Gabriëlle H.S., additional, Prokofyeva, Elena, additional, Alves, Dalila, additional, Cachulo, Maria L., additional, Khawaja, Anthony P., additional, Cougnard-Gregoire, Audrey, additional, Merle, Bénédicte M.J., additional, Korb, Christina, additional, Erke, Maja G., additional, Bron, Alain, additional, Anastasopoulos, Eleftherios, additional, Meester-Smoor, Magda A., additional, Segato, Tatiana, additional, Piermarocchi, Stefano, additional, de Jong, Paulus T.V.M., additional, Vingerling, Johannes R., additional, Topouzis, Fotis, additional, Creuzot-Garcher, Catherine, additional, Bertelsen, Geir, additional, Pfeiffer, Norbert, additional, Fletcher, Astrid E., additional, Foster, Paul J., additional, Silva, Rufino, additional, Korobelnik, Jean-François, additional, Delcourt, Cécile, additional, Klaver, Caroline C.W., additional, Ajana, Soufiane, additional, Arango-Gonzalez, Blanca, additional, Arndt, Verena, additional, Bhatia, Vaibhav, additional, Bhattacharya, Shomi S., additional, Biarnés, Marc, additional, Borrell, Anna, additional, Bühren, Sebastian, additional, Calado, Sofia M., additional, Colijn, Johanna M., additional, Cougnard-Grégoire, Audrey, additional, Dammeier, Sascha, additional, de Jong, Eiko K., additional, De la Cerda, Berta, additional, den Hollander, Anneke I., additional, Diaz-Corrales, Francisco J., additional, Diether, Sigrid, additional, Emri, Eszter, additional, Endermann, Tanja, additional, Ferraro, Lucia L., additional, Garcia, Míriam, additional, Heesterbeek, Thomas J., additional, Honisch, Sabina, additional, Hoyng, Carel B., additional, Kersten, Eveline, additional, Kilger, Ellen, additional, Langen, Hanno, additional, Lengyel, Imre, additional, Luthert, Phil, additional, Maugeais, Cyrille, additional, Meester-Smoor, Magda, additional, Monés, Jordi, additional, Nogoceke, Everson, additional, Peto, Tunde, additional, Pool, Frances M., additional, Rodríguez, Eduardo, additional, Ueffing, Marius, additional, Ulrich Bartz-Schmidt, Karl U., additional, van Leeuwen, Elisabeth M., additional, Verzijden, Timo, additional, Zumbansen, Markus, additional, Acar, Niyazi, additional, Anastosopoulos, Eleftherios, additional, Azuara-Blanco, Augusto, additional, Bergen, Arthur, additional, Binquet, Christine, additional, Bird, Alan, additional, Brétillon, Lionel, additional, Buitendijk, Gabrielle, additional, Cachulo, Maria Luz, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chang, Petrus, additional, Colijn, Johanna, additional, Cumberland, Philippa, additional, Cunha-Vaz, José, additional, Daien, Vincent, additional, Deak, Gabor, additional, Delyfer, Marie-Noëlle, additional, den Hollander, Anneke, additional, Dietzel, Martha, additional, Erke, Maja Gran, additional, Fauser, Sascha, additional, Finger, Robert, additional, Fletcher, Astrid, additional, Foster, Paul, additional, Founti, Panayiota, additional, Göbel, Arno, additional, Gorgels, Theo, additional, Grauslund, Jakob, additional, Grus, Franz, additional, Hammond, Christopher, additional, Helmer, Catherine, additional, Hense, Hans-Werner, additional, Hermann, Manuel, additional, Hoehn, René, additional, Hogg, Ruth, additional, Holz, Frank, additional, Hoyng, Carel, additional, Jansonius, Nomdo, additional, Janssen, Sarah, additional, Khawaja, Anthony, additional, Klaver, Caroline, additional, Lamparter, Julia, additional, Le Goff, Mélanie, additional, Leal, Sergio, additional, Lechanteur, Yara, additional, Lehtimäki, Terho, additional, Lotery, Andrew, additional, Leung, Irene, additional, Mauschitz, Matthias, additional, Merle, Bénédicte, additional, Meyer zu Westrup, Verena, additional, Midena, Edoardo, additional, Miotto, Stefania, additional, Mirshahi, Alireza, additional, Mohan-Saïd, Sadek, additional, Mueller, Michael, additional, Muldrew, Alyson, additional, Nunes, Sandrina, additional, Oexle, Konrad, additional, Rahi, Jugnoo, additional, Raitakari, Olli, additional, Ribeiro, Luisa, additional, Rougier, Marie-Bénédicte, additional, Sahel, José, additional, Salonikiou, Aggeliki, additional, Sanchez, Clarisa, additional, Schmitz-Valckenberg, Steffen, additional, Schweitzer, Cédric, additional, Shehata, Jasmin, additional, Silvestri, Giuliana, additional, Simader, Christian, additional, Souied, Eric, additional, Springelkamp, Henriet, additional, Tapp, Robyn, additional, Verhoeven, Virginie, additional, Von Hanno, Therese, additional, Vujosevic, Stela, additional, Williams, Katie, additional, Wolfram, Christian, additional, Yip, Jennifer, additional, Zerbib, Jennyfer, additional, and Zwiener, Isabella, additional

Published
2017
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9. Intravitreal Aflibercept for Diabetic Macular Edema

Author

Heier, Jeffrey S., primary, Korobelnik, Jean-François, additional, Brown, David M., additional, Schmidt-Erfurth, Ursula, additional, Do, Diana V., additional, Midena, Edoardo, additional, Boyer, David S., additional, Terasaki, Hiroko, additional, Kaiser, Peter K., additional, Marcus, Dennis M., additional, Nguyen, Quan D., additional, Jaffe, Glenn J., additional, Slakter, Jason S., additional, Simader, Christian, additional, Soo, Yuhwen, additional, Schmelter, Thomas, additional, Vitti, Robert, additional, Berliner, Alyson J., additional, Zeitz, Oliver, additional, Metzig, Carola, additional, and Holz, Frank G., additional

Published
2016
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10. Intravitreal Aflibercept for Diabetic Macular Edema: 100-Week Results From the VISTA and VIVID Studies

Author

Brown, David M, Schmidt Erfurth, Ursula, Diana V., Do, Holz, Frank G., Boyer, David S., Midena, Edoardo, Heier, Jeffrey S., Terasaki, Hiroko, Kaiser, Peter K., Marcus, Dennis M., Nguyen, Quan D., Jaffe, Glenn J., Slakter, Jason S., Simader, Christian, Soo, Yuhwen, Schmelter, Thomas, Yancopoulos, George D., Stahl, Neil, Vitti, Robert, Berliner, Alyson J., Zeitz, Oliver, Metzig, Carola, and Korobelnik, Jean François

Subjects
Vascular Endothelial Growth Factor A, Diabetic Retinopathy, Laser Coagulation, Recombinant Fusion Proteins, Visual Acuity, Angiogenesis Inhibitors, Macular Edema, Ophthalmology, Diabetes Mellitus, Type 1, Receptors, Vascular Endothelial Growth Factor, Diabetes Mellitus, Type 2, Double-Blind Method, Sickness Impact Profile, Intravitreal Injections, Humans, Fluorescein Angiography, Tomography, Optical Coherence
Abstract

To compare efficacy and safety of 2 dosing regimens of intravitreal aflibercept injection (IAI) with macular laser photocoagulation for diabetic macular edema (DME).Two similarly designed, randomized, phase 3 trials, VISTA(DME) and VIVID(DME).Patients (eyes; n=872) with type 1 or 2 diabetes mellitus who had DME with central involvement.Eyes received IAI 2 mg every 4 weeks (2q4), IAI 2 mg every 8 weeks after 5 monthly doses (2q8), or laser control.The primary end point was mean change from baseline in best-corrected visual acuity (BCVA) at week 52. This report presents the 100-week results including mean change from baseline in BCVA, proportion of eyes that gained ≥15 letters, and proportion of eyes with a ≥2-step improvement in the Diabetic Retinopathy Severity Scale (DRSS) score.Mean BCVA gain from baseline to week 100 with IAI 2q4, IAI 2q8, and laser control was 11.5, 11.1, and 0.9 letters (P0.0001) in VISTA and 11.4, 9.4, and 0.7 letters (P0.0001) in VIVID, respectively. The proportion of eyes that gained ≥15 letters from baseline at week 100 was 38.3%, 33.1%, and 13.0% (P0.0001) in VISTA and 38.2%, 31.1%, and 12.1% (P ≤ 0.0001) in VIVID. The proportion of eyes that lost ≥15 letters at week 100 was 3.2%, 0.7%, and 9.7% (P ≤ 0.0220) in VISTA and 2.2%, 1.5%, and 12.9% (P ≤ 0.0008) in VIVID. Significantly more eyes in the IAI 2q4 and 2q8 groups versus those in the laser control group had a ≥2 step improvement in the DRSS score in both VISTA (37.0% and 37.1% vs. 15.6%; P0.0001) and VIVID (29.3% and 32.6% vs. 8.2%; P ≤ 0.0004). In an integrated safety analysis, the most frequent serious ocular adverse event was cataract (2.4%, 1.0%, and 0.3% for 2q4, 2q8, and control).In both VISTA and VIVID, the 52-week visual and anatomic superiority of IAI over laser control was sustained through week 100, with similar efficacy in the 2q4 and 2q8 groups. Safety in these studies was consistent with the known safety profile of IAI.

Published
2015

11. The Pediatric Choroidal and Ciliary Body Melanoma Study

Author

Al-Jamal, Rana'a T., primary, Cassoux, Nathalie, additional, Desjardins, Laurence, additional, Damato, Bertil, additional, Konstantinidis, Lazaros, additional, Coupland, Sarah E., additional, Heimann, Heinrich, additional, Petrovic, Aleksandra, additional, Zografos, Leonidas, additional, Schalenbourg, Ann, additional, Velazquez-Martin, Juan P., additional, Krema, Hatem, additional, Bogdali, Anna, additional, Markiewicz, Anna, additional, Romanowska-Dixon, Bozena, additional, Metz, Claudia H.D., additional, Biewald, Eva, additional, Bornfeld, Norbert, additional, Kiratli, Hayyam, additional, Bronkhorst, Inge H.G., additional, Jager, Martine J., additional, Marinkovic, Marina, additional, Fili, Maria, additional, Seregard, Stefan, additional, Frenkel, Shahar, additional, Pe'er, Jacob, additional, Salvi, Sachin M., additional, Rennie, Ian G., additional, Rospond-Kubiak, Iwona, additional, Kociecki, Jaroslaw, additional, Kiilgaard, Jens Folke, additional, Heegaard, Steffen, additional, Cohen, Victoria M.L., additional, Sagoo, Mandeep S., additional, Amiryan, Anush, additional, Saakyan, Svetlana, additional, Eide, Nils, additional, Krohn, Jørgen, additional, Midena, Edoardo, additional, Parrozzani, Raffaele, additional, Grange, Jean-Daniel, additional, Kilic, Emine, additional, Blasi, Maria Antonietta, additional, Saornil, Maria Antonia, additional, and Kivelä, Tero T., additional

Published
2016
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12. Intravitreal Aflibercept for Diabetic Macular Edema

Author

Korobelnik, Jean-François, primary, Do, Diana V., additional, Schmidt-Erfurth, Ursula, additional, Boyer, David S., additional, Holz, Frank G., additional, Heier, Jeffrey S., additional, Midena, Edoardo, additional, Kaiser, Peter K., additional, Terasaki, Hiroko, additional, Marcus, Dennis M., additional, Nguyen, Quan D., additional, Jaffe, Glenn J., additional, Slakter, Jason S., additional, Simader, Christian, additional, Soo, Yuhwen, additional, Schmelter, Thomas, additional, Yancopoulos, George D., additional, Stahl, Neil, additional, Vitti, Robert, additional, Berliner, Alyson J., additional, Zeitz, Oliver, additional, Metzig, Carola, additional, and Brown, David M., additional

Published
2014
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21. Ranibizumab Plus Panretinal Photocoagulation versus Panretinal Photocoagulation Alone for High-Risk Proliferative Diabetic Retinopathy (PROTEUS Study)

Author

Sarah Ayello Scheer, Emily Fletcher, Dalila Alves, Conceição Lobo, Catherine Creuzot-Garcher, Rufino Silva, João Figueira, Haralabos Eleftheriadis, João Nascimento, Miguel Amaro, Sandrina Nunes, Monica Varano, Pascale Massin, Geeta Menon, Francesco Bandello, Sobha Sivaprasad, José Cunha-Vaz, Edoardo Midena, Association for Innovation and Biomedical Research on Light and Image (AIBILI), Gloucestershire Hospitals, Partenaires INRAE, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Universita di Padova, IRCCS, King's Health Partners, Frimley Park Hospital NHS Foundation Trust, Hospital Vila Franca de Xira, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Department of Ophthalmology, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Instituto de Retina e Diabetes Ocular de Lisboa, Novartis, Bayer, Allergan, Roche, EVICR, Thea, Horus, Novartis Pharma AG., Figueira, João, Fletcher, Emily, Massin, Pascale, Silva, Rufino, Bandello, Francesco, Midena, Edoardo, Varano, Monica, Sivaprasad, Sobha, Eleftheriadis, Haralabo, Menon, Geeta, Amaro, Miguel, Ayello Scheer, Sarah, Creuzot-Garcher, Catherine, Nascimento, João, Alves, Dalila, Nunes, Sandrina, Lobo, Conceição, and Cunha-Vaz, José

Subjects
Male, Vascular Endothelial Growth Factor A, Visual acuity, medicine.medical_treatment, Visual Acuity, Angiogenesis Inhibitors, Vitrectomy, Retinal Neovascularization, law.invention, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, law, Prospective Studies, Fluorescein Angiography, Prospective cohort study, Tomography, Laser Coagulation, Diabetic retinopathy, Middle Aged, Combined Modality Therapy, 3. Good health, Intravitreal Injections, Retreatment, Female, medicine.symptom, Tomography, Optical Coherence, medicine.drug, Adult, medicine.medical_specialty, 03 medical and health sciences, Ranibizumab, Ophthalmology, medicine, Humans, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, Aged, Diabetic Retinopathy, business.industry, medicine.disease, chemistry, Optical Coherence, Vitreous hemorrhage, 030221 ophthalmology & optometry, Glycated hemoglobin, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

Supplemental material available at www.aaojournal.org.; International audience; PURPOSE: Comparison of the efficacy of ranibizumab (RBZ) 0.5 mg intravitreal injections plus panretinal photocoagulation (PRP) versus PRP alone in the regression of the neovascularization (NV) area in subjects with high-risk proliferative diabetic retinopathy (HR-PDR) over a 12-month period. DESIGN: Prospective, randomized, multicenter, open-label, phase II/III study. PARTICIPANTS: Eighty-seven participants (aged >/=18 years) with type 1/2 diabetes and HR-PDR (mean age, 55.2 years; 37% were female). METHODS: Participants were randomized (1:1) to receive RBZ+PRP (n = 41) or PRP monotherapy (n = 46). The RBZ+PRP group received 3 monthly RBZ injections along with standard PRP. The PRP monotherapy group received standard PRP between day 1 and month 2; thereafter, re-treatments in both groups were at the investigators' discretion. MAIN OUTCOME MEASURES: The primary outcome was regression of NV total, on the disc (NVD) plus elsewhere (NVE), defined as any decrease in the area of NV from the baseline to month 12. Secondary outcomes included best-corrected visual acuity (BCVA) changes from baseline to month 12, time to complete NV regression, recurrence of NV, macular retinal thickness changes from baseline to month 12, need for treatment for diabetic macular edema, need for vitrectomy because of occurrence of vitreous hemorrhage, tractional retinal detachment or other complications of DR, and adverse events (AEs) related to treatments. RESULTS: Seventy-seven participants (88.5%) completed the study. Overall baseline demographics were similar for both groups, except for age. At month 12, 92.7% of participants in the RBZ+PRP group presented NV total reduction versus 70.5% of the PRP monotherapy participants (P = 0.009). The number of participants with NVD and NVE reductions was higher with RBZ+PRP (93.3% and 91.4%, respectively) versus PRP (68.8% and 73.7%, respectively), significant only for NVE (P = 0.048). Complete NV total regression was observed in 43.9% in the RBZ+PRP group versus 25.0% in the PRP monotherapy group (P = 0.066). At month 12, the mean BCVA was 75.2 letters (20/32) in the RBZ+PRP group versus 69.2 letters (20/40) in the PRP monotherapy group (P = 0.104). In the RBZ+PRP group, the mean number of PRP treatments over month 12 was 3.5+/-1.3, whereas in the PRP monotherapy group, it was 4.6+/-1.5 (P = 0.001). No deaths or unexpected AEs were reported. CONCLUSIONS: Treatment with RBZ+PRP was more effective than PRP monotherapy for NV regression in HR-PDR participants over 12 months.

Published
2018

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