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2. Postinjection Endophthalmitis in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT)

Author

Meredith, Travis A, McCannel, Colin A, Barr, Charles, Doft, Bernard H, Peskin, Ellen, Maguire, Maureen G, Martin, Daniel F, Prenner, Jonathan L, and Group, Comparison of Age-Related Macular Degeneration Treatments Trials Research

Subjects
Macular Degeneration, Neurodegenerative, Clinical Trials and Supportive Activities, Clinical Research, Aging, Eye Disease and Disorders of Vision, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Eye, Aged, 80 and over, Angiogenesis Inhibitors, Anti-Bacterial Agents, Antibodies, Monoclonal, Humanized, Bevacizumab, Cohort Studies, Endophthalmitis, Eye Infections, Bacterial, Female, Humans, Incidence, Intravitreal Injections, Male, Middle Aged, Postoperative Complications, Ranibizumab, Treatment Outcome, Vascular Endothelial Growth Factor A, Visual Acuity, Wet Macular Degeneration, Comparison of Age-Related Macular Degeneration Treatments Trials Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

ObjectiveTo describe the incidence and outcomes of endophthalmitis after intravitreal injections of anti-vascular endothelial growth factor agents in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) and to assess the effect of prophylactic topical antimicrobials on incidence.DesignCohort study within a randomized clinical trial.ParticipantsPatients enrolled in CATT.MethodsPatients with neovascular age-related macular degeneration received intravitreal injections of ranibizumab or bevacizumab under 1 of 3 dosing regimens. The study protocol specified preinjection preparation to include use of a sterile lid speculum and povidone iodine (5%). Use of preinjection and postinjection antibiotics was at the discretion of the treating ophthalmologist. Patients were followed up monthly for 2 years.Main outcome measuresDevelopment of endophthalmitis and visual acuity.ResultsEndophthalmitis developed after 11 of 18 509 injections (1 per 1700 [0.06%]; 95% confidence interval, 0.03%-0.11%), and in 11 of 1185 patients (0.93%; 95% confidence interval, 0.52-1.66). Incidence of endophthalmitis was 0.15% among injections with no antibiotic use, 0.08% among injections with preinjection antibiotics only, 0.06% among injections with postinjection antibiotics only, and 0.04% among injections with preinjection and postinjection antibiotics (P = 0.20). All eyes were treated with intravitreal antibiotics and 4 underwent vitrectomy. Among the 11 affected eyes, the final study visual acuity was 20/40 or better in 4 eyes (36%), 20/50 to 20/80 in 2 eyes (18%), 20/100 to 20/160 in 3 eyes (27%), and worse than 20/800 in 2 eyes (18%). The final visual acuity was within 2 lines of the visual acuity before endophthalmitis in 5 eyes (45%).ConclusionsRates of endophthalmitis were low and similar to those in other large-scale studies. Use of topical antibiotics either before or after injection does not seem to reduce the risk for endophthalmitis.

Published
2015

4. Pneumatic Vitreolysis with Perfluoropropane for Vitreomacular Traction with and without Macular Hole

Author

Chan, Clement K., primary, Mein, Calvin E., additional, Glassman, Adam R., additional, Beaulieu, Wesley T., additional, Calhoun, Claire T., additional, Jaffe, Glenn J., additional, Jampol, Lee M., additional, MacCumber, Mathew W., additional, Maguire, Maureen G., additional, Maturi, Raj K., additional, Salehi-Had, Hani, additional, Rofagha, Soraya, additional, Sun, Jennifer K., additional, and Martin, Daniel F., additional

Published
2021
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10. Growth of Geographic Atrophy in the Comparison of Age-related Macular Degeneration Treatments Trials

Author

Grunwald, Juan E, Pistilli, Maxwell, Ying, Gui-shuang, Maguire, Maureen G, Daniel, Ebenezer, and Martin, Daniel F

Subjects
Male, Vascular Endothelial Growth Factor A, Visual Acuity, Angiogenesis Inhibitors, Antibodies, Monoclonal, Humanized, Polymorphism, Single Nucleotide, Article, Cohort Studies, Geographic Atrophy, Ranibizumab, Photography, Humans, Fluorescein Angiography, Aged, Aged, 80 and over, Serine Endopeptidases, Proteins, Complement C3, High-Temperature Requirement A Serine Peptidase 1, Toll-Like Receptor 3, Bevacizumab, Ophthalmology, Complement Factor H, Intravitreal Injections, Wet Macular Degeneration, Female
Abstract

To evaluate the growth of geographic atrophy (GA) during anti-vascular endothelial growth factor (VEGF) therapy.Cohort within a clinical trial.Patients included in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).Participants were randomly assigned to injections of ranibizumab or bevacizumab and to a 2-year dosing regimen of monthly or pro re nata (PRN) or to monthly for 1 year and PRN the following year. Digital color photographs and fluorescein angiograms at baseline and 1 and 2 years were evaluated for GA, and the total area of GA was measured by 2 graders masked to treatment; differences were adjudicated. Multivariate linear mixed models of the annual change in the square root of the area included baseline demographic, treatment, and ocular characteristics on imaging as candidate risk factors.Geographic atrophy growth rate.Among 1185 participants, 86 (7.3%) had GA at baseline, 120 (10.1%) developed GA during year 1, and 36 (3.0%) developed GA during year 2. Among 194 eyes evaluable for growth, the rate was 0.43 mm/yr (standard error [SE], ±0.03 mm/year). In multivariate analysis, the growth rate was 0.37 mm/year in eyes receiving bevacizumab and 0.49 mm/year in eyes receiving ranibizumab (difference, 0.11 mm/yr; 95% confidence interval [CI], 0.01-0.22; P = 0.03). Growth rate did not differ between eyes treated monthly and PRN (P = 0.85). Eyes with subfoveal choroidal neovascularization (CNV) lesions had a lower growth rate than eyes with nonsubfoveal CNV lesions (difference, 0.12; 95% CI, 0.01-0.22; P = 0.03). Eyes with GA farther from the fovea had higher growth rates by 0.14 (95% CI, 0.01-27) mm/year for every millimeter farther from the fovea. The growth rate was 0.58 mm/year for eyes with predominantly classic lesions, 0.41 mm/year for eyes with minimally classic lesions, and 0.30 mm/year for eyes with occult only lesions (P0.01). The growth rate in eyes having a fellow eye with GA was higher by 0.13 mm/year (95% CI, 0.01-0.24; P = 0.03) than in eyes without GA in the fellow eye. Eyes with epiretinal membrane had a higher growth rate than eyes without epiretinal membrane (difference, 0.16; 95% CI, 0.03-0.30; P = 0.02).Geographic atrophy growth depends on several ocular factors. Ranibizumab may accelerate GA growth.

Published
2015

13. Long-term Management of Panuveitis and Iris Heterochromia in an Ebola Survivor

Author

Shantha, Jessica G., primary, Crozier, Ian, additional, Varkey, Jay B., additional, Kraft, Colleen S., additional, Lyon, G. Marshall, additional, Mehta, Aneesh K., additional, Carlson, Renee Donahue, additional, Hill, Charles E., additional, Kumar, Gokul, additional, Debiec, Matthew R., additional, Patel, Purnima S., additional, Olsen, Timothy W., additional, Nussenblatt, Robert B., additional, Martin, Daniel F., additional, Ströher, Ute, additional, Uyeki, Timothy M., additional, Ribner, Bruce S., additional, Smith, Justine R., additional, and Yeh, Steven, additional

Published
2016
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21. Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

Author

Willoughby, Alex S., primary, Ying, Gui-shuang, additional, Toth, Cynthia A., additional, Maguire, Maureen G., additional, Burns, Russell E., additional, Grunwald, Juan E., additional, Daniel, Ebenezer, additional, Jaffe, Glenn J., additional, Williams, David F., additional, Beardsley, Sara, additional, Bennett, Steven, additional, Cantrill, Herbert, additional, Chan-Tram, Carmen, additional, Cheshier, Holly, additional, Damato, Kathyrn, additional, Davies, John, additional, Dev, Sundeep, additional, Enloe, Julianne, additional, Follano, Gennaro, additional, Gilbert, Peggy, additional, Johnson, Jill, additional, Jones, Tori, additional, Mayleben, Lisa, additional, Mittra, Robert, additional, Moos, Martha, additional, Neist, Ryan, additional, Oestreich, Neal, additional, Quiram, Polly, additional, Ramsay, Robert, additional, Ryan, Edwin, additional, Schindeldecker, Stephanie, additional, Snater, John, additional, Steele, Trenise, additional, Selders, Dwight, additional, Tonsfeldt, Jessica, additional, Valardi, Shelly, additional, Fish, Gary Edd, additional, Aguado, Hank A., additional, Arceneaux, Sally, additional, Arnwine, Jean, additional, Bell, Kim, additional, Bell, Tina, additional, Boleman, Bob, additional, Bradley, Patricia, additional, Callanan, David, additional, Coors, Lori, additional, Creighton, Jodi, additional, Crew, Timothy, additional, Cummings, Kimberly, additional, Dock, Christopher, additional, Duignan, Karen, additional, Fuller, Dwain, additional, Gray, Keith, additional, Hendrix, Betsy, additional, Hesse, Nicholas, additional, Jaramillo, Diana, additional, Jost, Bradley, additional, Lash, Sandy, additional, Lonsdale, Laura, additional, Mackens, Michael, additional, Mutz, Karin, additional, Potts, Michael, additional, Sanchez, Brenda, additional, Snyder, William, additional, Solley, Wayne, additional, Tarter, Carrie, additional, Wang, Robert, additional, Williams, Patrick, additional, Perkins, Stephen L., additional, Anderson, Nicholas, additional, Arnold, Ann, additional, Blais, Paul, additional, Googe, Joseph, additional, Higdon, Tina T., additional, Hunt, Cecile, additional, Johnson, Mary, additional, Miller, James, additional, Moore, Misty, additional, Morris, Charity K., additional, Morris, Christopher, additional, Oelrich, Sarah, additional, Oliver, Kristina, additional, Seitz, Vicky, additional, Whetstone, Jerry, additional, Doft, Bernard H., additional, Bedel, Jay, additional, Bergren, Robert, additional, Borthwick, Ann, additional, Conrad, Paul, additional, Fec, Amanda, additional, Fulwylie, Christina, additional, Ingram, Willia, additional, Latham, Shawnique, additional, Lester, Gina, additional, Liu, Judy, additional, Lobes, Louis, additional, Lucko, Nicole M., additional, Mechling, Holly, additional, Merlotti, Lori, additional, McBroom, Keith, additional, Olsen, Karl, additional, Puskas, Danielle, additional, Rath, Pamela, additional, Schmucker, Maria, additional, Schueckler, Lynn, additional, Schultz, Christina, additional, Shultz, Heather, additional, Steinberg, David, additional, Vyas, Avni, additional, Whale, Kim, additional, Yeckel, Kimberly, additional, Orth, David H., additional, Arredondo, Linda S., additional, Brown, Susan, additional, Ciscato, Barbara J., additional, Civantos, Joseph M., additional, Figliulo, Celeste, additional, Hasan, Sohail, additional, Kosinski, Belinda, additional, Muir, Dan, additional, Nelson, Kiersten, additional, Packo, Kirk, additional, Pollack, John S., additional, Rezaei, Kourous, additional, Shelton, Gina, additional, Townsend-Patrick, Shannya, additional, Walsh, Marian, additional, Richard McDonald, H., additional, Ansari, Nina, additional, Bye, Amanda, additional, Fu, Arthur D., additional, Grout, Sean, additional, Indermill, Chad, additional, Johnson, Robert N., additional, Michael Jumper, J., additional, Linares, Silvia, additional, Lujan, Brandon J., additional, Munden, Ames, additional, Persons, Meredith, additional, Rodriguez, Rosa, additional, Rose, Jennifer M., additional, Teske, Brandi, additional, Urias, Yesmin, additional, Young, Stephen, additional, Dreyer, Richard F., additional, Daniel, Howard, additional, Connaughton, Michele, additional, Handelman, Irvin, additional, Hobbs, Stephen, additional, Hoerner, Christine, additional, Hudson, Dawn, additional, Kopfer, Marcia, additional, Lee, Michael, additional, Lemley, Craig, additional, Logan, Joe, additional, Ma, Colin, additional, Mallet, Christophe, additional, Milliron, Amanda, additional, Peters, Mark, additional, Wohlsein, Harry, additional, Pearlman, Joel A., additional, Andrews, Margo, additional, Bartlett, Melissa, additional, Carlson, Nanette, additional, Cox, Emily, additional, Equi, Robert, additional, Gonzalez, Marta, additional, Griffin, Sophia, additional, Hogue, Fran, additional, Kennedy, Lance, additional, Kryuchkov, Lana, additional, Lopez, Carmen, additional, Lopez, Danny, additional, Luevano, Bertha, additional, McKenna, Erin, additional, Patel, Arun, additional, Reed, Brian, additional, Secor, Nyla, additional, Sison, Iris R., additional, Tsai, Tony, additional, Varghis, Nina, additional, Waller, Brooke, additional, Wendel, Robert, additional, Yebra, Reina, additional, Roth, Daniel B., additional, Deinzer, Jane, additional, Fine, Howard, additional, Green, Flory, additional, Green, Stuart, additional, Keyser, Bruce, additional, Leff, Steven, additional, Leviton, Amy, additional, Martir, Amy, additional, Mosenthine, Kristin, additional, Muscle, Starr, additional, Okoren, Linda, additional, Parker, Sandy, additional, Prenner, Jonathan, additional, Price, Nancy, additional, Rogers, Deana, additional, Rosas, Linda, additional, Schlosser, Alex, additional, Studenko, Loretta, additional, Tantum, Thea, additional, Wheatley, Harold, additional, Trese, Michael T., additional, Aaberg, Thomas, additional, Bezaire, Denis, additional, Bridges, Craig, additional, Bryant, Doug, additional, Capone, Antonio, additional, Coleman, Michelle, additional, Consolo, Christina, additional, Cook, Cindy, additional, DuLong, Candice, additional, Garretson, Bruce, additional, Grooten, Tracy, additional, Hammersley, Julie, additional, Hassan, Tarek, additional, Jessick, Heather, additional, Jones, Nanette, additional, Kinsman, Crystal, additional, Krumlauf, Jennifer, additional, Lewis, Sandy, additional, Locke, Heather, additional, Margherio, Alan, additional, Markus, Debra, additional, Marsh, Tanya, additional, Neal, Serena, additional, Noffke, Amy, additional, Oh, Kean, additional, Pence, Clarence, additional, Preston, Lisa, additional, Raphaelian, Paul, additional, Regan, Virginia R., additional, Roberts, Peter, additional, Ruby, Alan, additional, Sarrafizadeh, Ramin, additional, Scherf, Marissa, additional, Scott, Sarita, additional, Sneed, Scott, additional, Staples, Lisa, additional, Terry, Brad, additional, Trese, Matthew T., additional, Videtich, Joan, additional, Williams, George, additional, Zajechowski, Mary, additional, Joseph, Daniel P., additional, Blinder, Kevin, additional, Boyd, Lynda, additional, Buckley, Sarah, additional, Crow, Meaghan, additional, Dinatale, Amanda, additional, Engelbrecht, Nicholas, additional, Forke, Bridget, additional, Gabel, Dana, additional, Grand, Gilbert, additional, Grillion-Cerone, Jennifer, additional, Holekamp, Nancy, additional, Kelly, Charlotte, additional, Nobel, Ginny, additional, Pepple, Kelly, additional, Raeber, Matt, additional, Kumar Rao, P., additional, Ressel, Tammy, additional, Schremp, Steven, additional, Sgorlon, Merrilee, additional, Shears, Shantia, additional, Thomas, Matthew, additional, Timma, Cathy, additional, Vaughn, Annette, additional, Walters, Carolyn, additional, Weeks, Rhonda, additional, Wehmeier, Jarrod, additional, Wright, Tim, additional, Berinstein, Daniel M., additional, Ayyad, Aida, additional, Barazi, Mohammed K., additional, Bickhart, Erica, additional, Brady, Tracey, additional, Byank, Lisa, additional, Cronise, Alysia, additional, Denny, Vanessa, additional, Dunn, Courtney, additional, Flory, Michael, additional, Frantz, Robert, additional, Garfinkel, Richard A., additional, Gilbert, William, additional, Lai, Michael M., additional, Melamud, Alexander, additional, Newgen, Janine, additional, Newton, Shamekia, additional, Oliver, Debbie, additional, Osman, Michael, additional, Sanders, Reginald, additional, von Fricken, Manfred, additional, Dugel, Pravin, additional, Arenas, Sandra, additional, Balea, Gabe, additional, Bartoli, Dayna, additional, Bucci, John, additional, Cornelius, Jennifer A., additional, Dickens, Scheleen, additional, Doherty, Don, additional, Dunlap, Heather, additional, Goldenberg, David, additional, Jamal, Karim, additional, Jimenez, Norma, additional, Kavanagh, Nicole, additional, Kunimoto, Derek, additional, Martin, John, additional, Miner, Jessica, additional, Mobley, Sarah, additional, Park, Donald, additional, Quinlan, Edward, additional, Sipperley, Jack, additional, Slagle, Carol, additional, Smith, Danielle, additional, Yafchak, Miguelina, additional, Yager, Rohana, additional, Flaxel, Christina J., additional, Bailey, Steven, additional, Francis, Peter, additional, Howell, Chris, additional, Hwang, Thomas, additional, Ira, Shirley, additional, Klein, Michael, additional, Lauer, Andreas, additional, Liesegang, Teresa, additional, Lundquist, Ann, additional, Nolte, Sarah, additional, Nolte, Susan K., additional, Pickell, Scott, additional, Pope, Susan, additional, Rossi, Joseph, additional, Schain, Mitchell, additional, Steinkamp, Peter, additional, Toomey, Maureen D., additional, Vahrenwald, Debora, additional, West, Kelly, additional, Hubbard, Baker, additional, Andelman, Stacey, additional, Bergstrom, Chris, additional, Brower, Judy, additional, Cribbs, Blaine, additional, Curtis, Linda, additional, Dobbs, Jannah, additional, DuBois, Lindreth, additional, Gaultney, Jessica, additional, Gibbs, Deborah, additional, Jordan, Debora, additional, Leef, Donna, additional, Martin, Daniel F., additional, Myles, Robert, additional, Olsen, Timothy, additional, Schwent, Bryan, additional, Srivastava, Sunil, additional, Waldron, Rhonda, additional, Antoszyk, Andrew N., additional, Balasubramaniam, Uma, additional, Brooks, Danielle, additional, Brown, Justin, additional, Browning, David, additional, Clark, Loraine, additional, Ennis, Sarah, additional, Held, Susannah, additional, Helms, Jennifer V., additional, Herby, Jenna, additional, Karow, Angie, additional, Leotaud, Pearl, additional, Massimino, Caterina, additional, McClain, Donna, additional, McOwen, Michael, additional, Mindel, Jennifer, additional, Pereira, Candace, additional, Pierce, Rachel, additional, Powers, Michele, additional, Price, Angela, additional, Rohrer, Jason, additional, Sanders, Jason, additional, Avery, Robert L., additional, Avery, Kelly, additional, Basefsky, Jessica, additional, Beckner, Liz, additional, Castellarin, Alessandro, additional, Couvillion, Stephen, additional, Giust, Jack, additional, Giust, Matthew, additional, Nasir, Maan, additional, Pieramici, Dante, additional, Rabena, Melvin, additional, Risard, Sarah, additional, See, Robert, additional, Smith, Jerry, additional, Wan, Lisha, additional, Bakri, Sophie J., additional, Abu-Yaghi, Nakhleh, additional, Barkmeier, Andrew, additional, Berg, Karin, additional, Burrington, Jean, additional, Edwards, Albert, additional, Goddard, Shannon, additional, Howard, Shannon, additional, Iezzi, Raymond, additional, Lewison, Denise, additional, Link, Thomas, additional, McCannel, Colin A., additional, Overend, Joan, additional, Pach, John, additional, Ruszczyk, Margaret, additional, Shultz, Ryan, additional, Stephan, Cindy, additional, Vogen, Diane, additional, Bradford, Reagan H., additional, Bergman, Vanessa, additional, Burris, Russ, additional, Butt, Amanda, additional, Daniels, Beth, additional, Dwiggins, Connie, additional, Fransen, Stephen, additional, Guerrero, Tiffany, additional, Haivala, Darin, additional, Harris, Amy, additional, Icks, Sonny, additional, Kingsley, Ronald, additional, Redden, Lena, additional, Richmond, Rob, additional, Ross, Brittany, additional, White, Kammerin, additional, Youngberg, Misty, additional, Topping, Trexler M., additional, Bennett, Steve, additional, Chong, Sandy, additional, Ciotti, Mary, additional, Cleary, Tina, additional, Corey, Emily, additional, Donovan, Dennis, additional, Frederick, Albert, additional, Freese, Lesley, additional, Graham, Margaret, additional, Gud, Natalya, additional, Howard, Taneika, additional, Jones, Mike, additional, Morley, Michael, additional, Moses, Katie, additional, Stone, Jen, additional, Ty, Robin, additional, Wiegand, Torsten, additional, Williams, Lindsey, additional, Winder, Beth, additional, Awh, Carl C., additional, Amonette, Michelle, additional, Arrindell, Everton, additional, Beck, Dena, additional, Busbee, Brandon, additional, Dilback, Amy, additional, Downs, Sara, additional, Guidry, Allison, additional, Gutow, Gary, additional, Hardin, Jackey, additional, Hines, Sarah, additional, Hutchins, Emily, additional, LaCivita, Kim, additional, Lester, Ashley, additional, Malott, Larry, additional, McCain, MaryAnn, additional, Miracle, Jayme, additional, Moffat, Kenneth, additional, Palazzotta, Lacy, additional, Robinson, Kelly, additional, Sonkin, Peter, additional, Travis, Alecia, additional, Wallace, Roy Trent, additional, Winters, Kelly J., additional, Wray, Julia, additional, Harris, April E., additional, Bunnell, Mari, additional, Crooks, Katrina, additional, Fitzgerald, Rebecca, additional, Javid, Cameron, additional, Kew, Corin, additional, Kill, Erica, additional, Kline, Patricia, additional, Kreienkamp, Janet, additional, Martinez, Maricruz, additional, Ann Moore, Roy, additional, Saavedra, Egbert, additional, Taylor, LuAnne, additional, Walsh, Mark, additional, Wilson, Larry, additional, Ciulla, Thomas A., additional, Coyle, Ellen, additional, Harrington, Tonya, additional, Harris, Charlotte, additional, Hood, Cindi, additional, Kerr, Ingrid, additional, Maturi, Raj, additional, Moore, Dawn, additional, Morrow, Stephanie, additional, Savage, Jennifer, additional, Sink, Bethany, additional, Steele, Tom, additional, Thukral, Neelam, additional, Wilburn, Janet, additional, Walker, Joseph P., additional, Banks, Jennifer, additional, Ciampaglia, Debbie, additional, Dyshanowitz, Danielle, additional, Frederick, Jennifer, additional, Tom Ghuman, A., additional, Grodin, Richard, additional, Kiesel, Cheryl, additional, Knips, Eileen, additional, McCue, Jonathan, additional, Ortiz, Maria, additional, Peters, Crystal, additional, Raskauskas, Paul, additional, Schoeman, Etienne, additional, Sharma, Ashish, additional, Wing, Glenn, additional, Youngblood, Rebecca, additional, Chandra, Suresh R., additional, Altaweel, Michael, additional, Blodi, Barbara, additional, Burke, Kathryn, additional, Dietzman, Kristine A., additional, Gottlieb, Justin, additional, Knutson, Gene, additional, Krolnik, Denise, additional, Michael Nork, T., additional, Olson, Shelly, additional, Peterson, John, additional, Reed, Sandra, additional, Soderling, Barbara, additional, Somers, Guy, additional, Stevens, Thomas, additional, Wealti, Angela, additional, Bearelly, Srilaxmi, additional, Branchaud, Brenda, additional, Bryant, Joyce W., additional, Crowell, Sara, additional, Fekrat, Sharon, additional, Gammage, Merritt, additional, Harrison, Cheala, additional, Jones, Sarah, additional, McClain, Noreen, additional, McCuen, Brooks, additional, Mruthyunjaya, Prithvi, additional, Queen, Jeanne, additional, Sarin, Neeru, additional, Skalak, Cindy, additional, Skelly, Marriner, additional, Suner, Ivan, additional, Tomany, Ronnie, additional, Welch, Lauren, additional, Park, Susanna S., additional, Cassidy, Allison, additional, Chandra, Karishma, additional, Good, Idalew, additional, Imson, Katrina, additional, Kaur, Sashi, additional, Metzler, Helen, additional, Morse, Lawrence, additional, Redenbo, Ellen, additional, Salvador, Marisa, additional, Telander, David, additional, Thomas, Mark, additional, Wallace, Cindy, additional, Barr, Charles C., additional, Battcher, Amanda, additional, Bottorff, Michelle, additional, Chasteen, Mary, additional, Clark, Kelly, additional, Denning, Diane, additional, Schoen, Debra, additional, Schultz, Amy, additional, Tempel, Evie, additional, Wheeler, Lisa, additional, Whittington, Greg K., additional, Stone, Thomas W., additional, Blevins, Todd, additional, Buck, Michelle, additional, Cruz, Lynn, additional, Heath, Wanda, additional, Holcomb, Diana, additional, Isernhagen, Rick, additional, Kidd, Terri, additional, Kitchens, John, additional, Sears, Cathy, additional, Slade, Ed, additional, Van Arsdall, Jeanne, additional, VanHoose, Brenda, additional, Wolfe, Jenny, additional, Wood, William, additional, Zilis, John, additional, Crooks, Carol, additional, Disney, Larry, additional, Liu, Mimi, additional, Petty, Stephen, additional, Sall, Sandra, additional, Folk, James C., additional, Aly, Tracy, additional, Brotherton, Abby, additional, Critser, Douglas, additional, Hinz, Connie J., additional, Karakas, Stefani, additional, Kirschner, Valerie, additional, Lester, Cheyanne, additional, Montague, Cindy, additional, Russell, Stephen, additional, Stockman, Heather, additional, Taylor, Barbara, additional, Verdick, Randy, additional, Walshire, Jean, additional, Thompson, John T., additional, Connell, Barbara, additional, Constantine, Maryanth, additional, Davis, John L., additional, Holsapple, Gwen, additional, Hunter, Lisa, additional, Lenane, C. Nicki, additional, Mitchell, Robin, additional, Russel, Leslie, additional, Sjaarda, Raymond, additional, Brown, David M., additional, Benz, Matthew, additional, Burns, Llewellyn, additional, Carranza, JoLene G., additional, Fish, Richard, additional, Goates, Debra, additional, Hay, Shayla, additional, Jeffers, Theresa, additional, Kegley, Eric, additional, Kubecka, Dallas, additional, McGilvra, Stacy, additional, Richter, Beau, additional, Sneed, Veronica, additional, Stoever, Cary, additional, Tellez, Isabell, additional, Wong, Tien, additional, Kim, Ivana, additional, Andreoli, Christopher, additional, Barresi, Leslie, additional, Brett, Sarah, additional, Callahan, Charlene, additional, Capaccioli, Karen, additional, Carli, William, additional, Coppola, Matthew, additional, Emmanuel, Nicholas, additional, Evans, Claudia, additional, Fagan, Anna, additional, Grillo, Marcia, additional, Head, John, additional, Kieser, Troy, additional, Lee, Elaine, additional, Lord, Ursula, additional, Miretsky, Edward, additional, Palitsch, Kate, additional, Petrin, Todd, additional, Reader, Liz, additional, Reznichenko, Svetlana, additional, Robertson, Mary, additional, Smith, Justin, additional, Vavvas, Demetrios, additional, Wells, John, additional, Cahill, Cassie, additional, Lloyd Clark, W., additional, Henry, Kayla, additional, Johnson, David, additional, Miller, Peggy, additional, Oliver, LaDetrick, additional, Spivey, Robbin, additional, Swinford, Tiffany, additional, Taylor, Mallie, additional, Lambert, Michael, additional, Chase, Kris, additional, Fredrickson, Debbie, additional, Khawly, Joseph, additional, Lazarte, Valerie, additional, Lowd, Donald, additional, Miller, Pam, additional, Willis, Arthur, additional, Ferrone, Philip J., additional, Almonte, Miguel, additional, Arnott, Rachel, additional, Aviles, Ingrid, additional, Carbon, Sheri, additional, Chitjian, Michael, additional, DAmore, Kristen, additional, Elliott, Christin, additional, Fastenberg, David, additional, Golub, Barry, additional, Graham, Kenneth, additional, Lavorna, AnnMarie, additional, Murphy, Laura, additional, Palomo, Amanda, additional, Puglisi, Christina, additional, Rhee, David, additional, Romero, Juan, additional, Rosenblatt, Brett, additional, Salcedo, Glenda, additional, Schlameuss, Marianne, additional, Shakin, Eric, additional, Sookhai, Vasanti, additional, Kaiser, Richard, additional, Affel, Elizabeth, additional, Brown, Gary, additional, Centinaro, Christina, additional, Fine, Deborah, additional, Fineman, Mitchell, additional, Formoso, Michele, additional, Garg, Sunir, additional, Grande, Lisa, additional, Herbert, Carolyn, additional, Ho, Allen, additional, Hsu, Jason, additional, Jay, Maryann, additional, Lavetsky, Lisa, additional, Liebenbaum, Elaine, additional, Maguire, Joseph, additional, Monsonego, Julia, additional, O'Connor, Lucia, additional, Pierce, Lisa, additional, Regillo, Carl, additional, Rosario, Maria, additional, Spirn, Marc, additional, Vander, James, additional, Walsh, Jennifer, additional, Davidorf, Frederick H., additional, Barnett, Amanda, additional, Chang, Susie, additional, Christoforidis, John, additional, Elliott, Joy, additional, Justice, Heather, additional, Letson, Alan, additional, McKinney, Kathryne, additional, Perry, Jeri, additional, Salerno, Jill A., additional, Savage, Scott, additional, Shelley, Stephen, additional, Singerman, Lawrence J., additional, Coney, Joseph, additional, DuBois, John, additional, DuBois, Kimberly, additional, Greanoff, Gregg, additional, Himmelman, Dianne, additional, Ilc, Mary, additional, Mcnamara, Elizabeth, additional, Novak, Michael, additional, Pendergast, Scott, additional, Rath, Susan, additional, Smith-Brewer, Sheila, additional, Tanner, Vivian, additional, Weiss, Diane E., additional, Zegarra, Hernando, additional, Halperin, Lawrence, additional, Aramayo, Patricia, additional, Dhalla, Mandeep, additional, Fernandez, Brian, additional, Fernandez, Cindy, additional, Lopez, Jaclyn, additional, Lopez, Monica, additional, Mariano, Jamie, additional, Murphy, Kellie, additional, Sherley, Clifford, additional, Veksler, Rita, additional, Rahhal, Firas, additional, Babikian, Razmig, additional, Boyer, David, additional, Hami, Sepideh, additional, Kessinger, Jeff, additional, Kurokouchi, Janet, additional, Mukarram, Saba, additional, Pachman, Sarah, additional, Protacio, Eric, additional, Sierra, Julio, additional, Tabandeh, Homayoun, additional, Zamboni, Adam, additional, Elman, Michael, additional, Belz, Jennifer, additional, Butcher, Tammy, additional, Cain, Theresa, additional, Coffey, Teresa, additional, Firestone, Dena, additional, Gore, Nancy, additional, Singletary, Pamela, additional, Sotirakos, Peter, additional, Starr, JoAnn, additional, Meredith, Travis A., additional, Barnhart, Cassandra J., additional, Cantrell, Debra, additional, Esquejo-Leon, RonaLyn, additional, Houghton, Odette, additional, Kaur, Harpreet, additional, NDure, Fatoumatta, additional, Glatzer, Ronald, additional, Joffe, Leonard, additional, Schindler, Reid, additional, Fine, Stuart L., additional, Katz, Marilyn, additional, Brightwell-Arnold, Mary, additional, Glaser, Ruchira, additional, Hall, Judith, additional, Harkins, Sandra, additional, Huang, Jiayan, additional, Khvatov, Alexander, additional, McWilliams, Kathy, additional, Peskin, Ellen, additional, Pistilli, Maxwell, additional, Ryan, Susan, additional, Schnader, Allison, additional, Ying, Gui-Shuang, additional, Jaffe, Glenn, additional, Afrani-Sakyi, Jennifer, additional, Balsley, Brannon, additional, Bennett, Linda S., additional, Brooks, Adam, additional, Brower-Lingsch, Adrienne, additional, Bruce, Lori, additional, Burns, Russell, additional, Busian, Dee, additional, Choong, John, additional, Cloaninger, Lindsey, additional, DeCroos, Francis Char, additional, DuBois, Emily, additional, El-Dairi, Mays, additional, Gach, Sarah, additional, Hall, Katelyn, additional, Hawks, Terry, additional, Huang, ChengChenh, additional, Heydary, Cindy, additional, Ho, Alexander, additional, Kini, Shashi, additional, McCall, Michelle, additional, Muhammad, Daaimah, additional, Nicholson, Jayne, additional, Rieves, Pamela, additional, Shields, Kelly, additional, Specker, Adam, additional, Stinnett, Sandra, additional, Subramaniam, Sujatha, additional, Tenbrink, Patrick, additional, Toth, Cynthia, additional, Towe, Aaron, additional, Welch, Kimberly, additional, Williams, Natasha, additional, Winter, Katrina, additional, Young, Ellen, additional, Alexander, Judith, additional, Flannagan, Elisabeth, additional, Martin, E. Revell, additional, Parker, Candace, additional, Sepielli, Krista, additional, Shannon, Tom, additional, Whearry, Claressa, additional, Redford, Maryann, additional, Kopfer, Marcia R., additional, Ferris, Frederick L., additional, DuPont, Joan, additional, Friedman, Lawrence M., additional, Bressler, Susan B., additional, DeMets, David L., additional, Friedlander, Martin, additional, Johnson, Mark W., additional, Lindblad, Anne, additional, Losordo, Douglas W., additional, and Miller, Franklin G., additional

Published
2015
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25. Author reply

Author

Hagstrom, Stephanie A., primary, Ying, Gui-shuang, additional, Maguire, Maureen G., additional, and Martin, Daniel F., additional

Published
2014
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28. Risk of Geographic Atrophy in the Comparison of Age-related Macular Degeneration Treatments Trials

Author

Grunwald, Juan E., primary, Daniel, Ebenezer, additional, Huang, Jiayan, additional, Ying, Gui-shuang, additional, Maguire, Maureen G., additional, Toth, Cynthia A., additional, Jaffe, Glenn J., additional, Fine, Stuart L., additional, Blodi, Barbara, additional, Klein, Michael L., additional, Martin, Alison A., additional, Hagstrom, Stephanie A., additional, and Martin, Daniel F., additional

Published
2014
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29. Incidence of Choroidal Neovascularization in the Fellow Eye in the Comparison of Age-related Macular Degeneration Treatments Trials

Author

Maguire, Maureen G., primary, Daniel, Ebenezer, additional, Shah, Ankoor R., additional, Grunwald, Juan E., additional, Hagstrom, Stephanie A., additional, Avery, Robert L., additional, Huang, Jiayan, additional, Martin, Revell W., additional, Roth, Daniel B., additional, Castellarin, Alessandro A., additional, Bakri, Sophie J., additional, Fine, Stuart L., additional, and Martin, Daniel F., additional

Published
2013
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32. Baseline Predictors for One-Year Visual Outcomes with Ranibizumab or Bevacizumab for Neovascular Age-related Macular Degeneration

Author

Ying, Gui-shuang, primary, Huang, Jiayan, additional, Maguire, Maureen G., additional, Jaffe, Glenn J., additional, Grunwald, Juan E., additional, Toth, Cynthia, additional, Daniel, Ebenezer, additional, Klein, Michael, additional, Pieramici, Dante, additional, Wells, John, additional, and Martin, Daniel F., additional

Published
2013
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33. Photographic Assessment of Baseline Fundus Morphologic Features in the Comparison of Age-related Macular Degeneration Treatments Trials

Author

Grunwald, Juan E., primary, Daniel, Ebenezer, additional, Ying, Gui-shuang, additional, Pistilli, Maxwell, additional, Maguire, Maureen G., additional, Alexander, Judith, additional, Whittock-Martin, Revell, additional, Parker, Candace R., additional, Sepielli, Krista, additional, Blodi, Barbara A., additional, and Martin, Daniel F., additional

Published
2012
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37. Cat scratch disease☆Posterior segment manifestations

Author

Solley, Wayne A, primary, Martin, Daniel F, additional, Newman, Nancy J, additional, King, Robert, additional, Callanan, David G, additional, Zacchei, Tony, additional, Wallace, R.Trent, additional, Parks, David J, additional, Bridges, William, additional, and Sternberg Jr, Paul, additional

Published
1999
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38. Uveal lymphoid infiltration

Author

Grossniklaus, Hans E, primary, Martin, Daniel F, additional, Avery, Robert, additional, Shields, Jerry A, additional, Shields, Carol L, additional, Kuo, Irene C, additional, Green, Ronald L, additional, and Rao, Narsing A, additional

Published
1998
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42. Intraocular Lymphoma

Author

Whitcup, Scott M., primary, de Smet, Marc D., additional, Rubin, Benjamin I., additional, Palestine, Alan G., additional, Martin, Daniel F., additional, Burnier, Miguel, additional, Chan, Chi-Chao, additional, and Nussenblatt, Robert B., additional

Published
1993
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44. Pathological Findings in Eyes with the Ganciclovir Implant

Author

Srivastava, Sunil K., Martin, Daniel F., Mellow, Susan D., Parks, David J., Dastgheib, Kourosh, and Chan, Chi-Chao

Subjects
*GANCICLOVIR, *ANTIVIRAL agents, *HEMORRHAGE, *MEDICAL informatics
Abstract

Objective: To examine the pathologic findings of eyes treated with ganciclovir implants. Design: Retrospective consecutive case series. Participants: Thirty-three eyes from 19 AIDS patients with ganciclovir implants. Methods: Pathologic specimens collected from 1993 through 1999 at the National Eye Institute were reviewed. Thirty-three eyes from 19 patients were identified with ganciclovir implants. The submitted eyes then were sectioned through the implant site and stained with hematoxylin and eosin, periodic acid-Schiff, and other special stains when needed. Medical records, including operative and postoperative notes, were reviewed carefully. Main Outcome Measure: Light microscopic findings at and around the site of implantation. Results: Scars of surgical perforation were present in all eyes. Fibrous ingrowth developed from the implant site into the vitreous in 32 of the 33 eyes. Vitreous hemorrhage was present in 18 of the 33 eyes. Poor wound apposition was found in 2 of the 33 eyes, both of which had undergone multiple procedures. Foreign body giant cell reactions were observed in most of the eyes related to suture material. Thirty-two of the 37 implant sites were located within the pars plana, whereas the other 5 were either on the border of the pars plana and pars plicata (n = 4) or within the pars plicata (n = 1). Hyalinization, atrophic changes of the ciliary body in the area of implantation, or both were observed in 18 eyes. Conclusions: The ganciclovir implant is well tolerated within the eye. Fibrous ingrowth is present in most eyes and seems to be a benign occurrence because of its limited extension. Microscopic vitreous hemorrhage is present in many eyes, especially those that underwent multiple procedures. Poor wound apposition occurred rarely and was found only in eyes that had undergone multiple procedures. [Copyright &y& Elsevier]

Published
2005
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45. Primary intraocular lymphoma: Clinical, cytologic, and flow cytometric analysis

Author

Zaldivar, Renzo A., Martin, Daniel F., Holden, Jeannine T., and Grossniklaus, Hans E.

Subjects
*LYMPHOMAS, *CYTOLOGISTS, *VITRECTOMY, *RETICULOENDOTHELIAL granulomas
Abstract

Purpose: To compare cytologic with flow cytometric results of vitreous biopsy specimens obtained to rule out primary intraocular lymphoma (PIOL).Study design: Prospective noncomparative case series.Participants: Patients suspected of having PIOL who underwent vitreous biopsy were evaluated.Methods: Patients underwent a standard 3-port vitrectomy and vitreous biopsy to rule out PIOL. Each undiluted specimen was split, and half was prepared for cytologic evaluation with the collodion bag method; the other half was submitted for flow cytometric immunophenotyping (FCI). The diluted specimen was processed as a cell block for cytology.Main outcome measures: Final diagnosis based on cytology and FCI.Results: Ten of 14 patients had sufficient specimens for both cytologic and FCI evaluation. Three patients had chronic inflammation confirmed by both methods. Six patients had large cell lymphoma identified by both cytology and FCI. Two of those 6 patients initially had insufficient specimen for FCI. One patient had large cell lymphoma diagnosed cytologically that was initially negative for a clonal population by FCI. All lymphomas were B-cell type.Conclusions: Cytologic evaluation is an accurate diagnostic technique to evaluate for PIOL. FCI is useful for immunophenotyping PIOL. Multiple biopsies may be required to achieve a diagnosis. [Copyright &y& Elsevier]

Published
2004
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46. Hypopyon uveitis and relapsing polychondritis: A report of 2 patients and review of autoimmune hypopyon uveitis

Author

Anderson, Nicholas G., Garcia-Valenzuela, Enrique, and Martin, Daniel F.

Subjects
*UVEITIS, *AUTOIMMUNE diseases, *PATIENTS, *EYE inflammation
Abstract

Objective: To report hypopyon uveitis as an ophthalmic finding associated with relapsing polychondritis.Design: Interventional case reports.Participants: Two patients with hypopyon uveitis as a manifestation of relapsing polychondritis.Methods: Complete ocular and systemic examinations as well as chart reviews were performed for 2 patients with hypopyon uveitis as a manifestation of relapsing polychondritis at presentation.Main outcome measurements: Clinical observation and response to treatment in 2 patients with hypopyon uveitis secondary to relapsing polychondritis.Results: A 70-year-old white male had unilateral hypopyon uveitis accompanied by a migratory polyarthralgia at presentation. Fifteen months later, he sought treatment for chondritis of the right auricle and was diagnosed with relapsing polychondritis. A 42-year-old white female with known relapsing polychondritis had bilateral hypopyon uveitis at presentation during a systemic relapse. Both patients had resolution of the hypopyon with topical and systemic steroids.Conclusions: Relapsing polychondritis should be considered in the differential diagnosis of sterile hypopyon uveitis. Steroids and systemic immunosuppression can be used to treat the uveitis. [Copyright &y& Elsevier]

Published
2004
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47. Outcomes of Eyes with Lesions Composed of >50% Blood in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

Author

Altaweel, Michael M., Daniel, Ebenezer, Martin, Daniel F., Mittra, Robert A., Grunwald, Juan E., Lai, Michael M., Melamud, Alexander, Morse, Lawrence S., Huang, Jiayan, IIIFerris, Frederick L., Fine, Stuart L., and Maguire, Maureen G.

Subjects
*HEALTH outcome assessment, *OCULAR injuries, *VISUAL acuity, *CLINICAL trials, *COMPARATIVE studies, AGE factors in retinal degeneration
Abstract

Objective To compare baseline characteristics, treatment frequency, visual acuity (VA), and morphologic outcomes of eyes with >50% of the lesion composed of blood (B50 group) versus all other eyes (Other group) enrolled in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Design Prospective cohort study within a multicenter randomized clinical trial. Participants CATT patients with neovascular age-related macular degeneration (AMD). Methods Treatment for the study eye was assigned randomly to either ranibizumab or bevacizumab and to 3 different dosing regimens over a 2-year period. Reading center graders evaluated baseline and follow-up morphology in color fundus photographs, fluorescein angiography (FA), and optical coherence tomography (OCT). Masked examiners tested VA. Main Outcome Measures Morphologic features and VA at 1 and 2 years. Results The B50 group consisted of 84 of 1185 (7.1%) patients enrolled in CATT. Baseline lesion characteristics differed between groups. In the B50 group, choroidal neovascularization size was smaller (0.73 vs 1.83 disc areas [DA]; P < 0.001), total lesion size was greater (4.55 vs 2.31 DA; P <0.001), total retinal thickness was greater (524 vs 455 μm; P = 0.02), and mean VA was worse (56.0 vs 60.9 letters; P = 0.002). Increases in mean VA were similar in the B50 and Other groups at 1 year (+9.3 vs +7.2 letters; P = 0.22) and at 2 years (9.0 vs 6.1 letters; P = 0.17). Eyes treated PRN received a similar number of injections in the 2 groups (12.2 vs 13.4; P = 0.27). Mean lesion size in the B50 group decreased by 1.2 DA at both 1 and 2 years (primarily owing to resolution of hemorrhage) and increased in the Other group by 0.33 DA at 1 year and 0.91 DA at 2 years ( P < 0.001). Leakage on FA and fluid on OCT were similar between groups at 1 and 2 years. Conclusions In CATT, the B50 group had a visual prognosis similar to the Other group. Lesion size decreased markedly through 2 years. Eyes like those enrolled in CATT with neovascular AMD lesions composed of >50% blood can be managed similarly to those with less or no blood. [ABSTRACT FROM AUTHOR]

Published
2015
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48. Influence of the Vitreomacular Interface on Treatment Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Author

Ciulla TA, Ying GS, Maguire MG, Martin DF, Jaffe GJ, Grunwald JE, Daniel E, and Toth CA

Subjects
Aged, Aged, 80 and over, Angiogenesis Inhibitors therapeutic use, Antibodies, Monoclonal, Humanized administration & dosage, Antibodies, Monoclonal, Humanized therapeutic use, Bevacizumab, Blood-Retinal Barrier, Cohort Studies, Female, Fluorescein Angiography, Humans, Intravitreal Injections, Male, Prospective Studies, Ranibizumab, Subretinal Fluid, Tissue Adhesions, Tomography, Optical Coherence, Treatment Outcome, Vascular Endothelial Growth Factor A antagonists & inhibitors, Visual Acuity physiology, Wet Macular Degeneration diagnosis, Wet Macular Degeneration physiopathology, Angiogenesis Inhibitors administration & dosage, Macula Lutea pathology, Retinal Diseases complications, Vitreous Body pathology, Wet Macular Degeneration drug therapy
Abstract

Objective: To assess the association of the vitreomacular interface with outcomes of eyes treated with anti-vascular endothelial growth factor drugs for neovascular age-related macular degeneration (AMD)., Design: Prospective cohort study within a multicenter, randomized clinical trial., Participants: Patients enrolled in the Comparison of AMD Treatments Trials (CATT)., Methods: Treatment was assigned randomly as either ranibizumab or bevacizumab and as 3 different regimens for dosing over a 2-year period. Masked readers at a reading center assessed optical coherence tomography (OCT) scans at baseline and follow-up for vitreomacular traction (VMT) and vitreomacular adhesion (VMA), fluid, and central thickness. Visual acuity (VA) was measured by masked, certified examiners., Main Outcome Measures: Anatomic features and VA at baseline and 1 and 2 years and number of treatments., Results: At baseline, 143 patient eyes (12.8%) had VMT or VMA. Compared with those with neither (n = 972), patients with VMT or VMA were younger (mean ± standard error, 75.5 ± 0.6 vs. 79.7 ± 0.24 years; P < 0.0001) and more likely to be male (52.4% vs. 36.2%; P = 0.0003), to be cigarette smokers (68.5% vs. 55.3%; P = 0.003), and to have subretinal fluid on OCT (86.7% vs. 81.0%; P = 0.047). Vitreomacular interface status was not associated with VA at baseline or follow-up. Among eyes treated as needed (n = 598) and followed up for 2 years (n = 516), the mean number of injections was 15.4 ± 0.9 for eyes having VMT at baseline or during follow-up (n = 60), 13.8 ± 0.7 for eyes with VMA at baseline or follow-up (n = 79), and 12.9 ± 0.4 (P = 0.02) for eyes without VMT or VMA (n = 377). In addition, the mean number of injections in eyes treated as needed increased from 13.0 ± 0.3 when VMT was not observed to 13.6 ± 1.3 when observed once and to 17 ± 1.2 when observed more than once during follow-up. At 2 years, geographic atrophy developed in a lower percentage of eyes with VMT or VMA at baseline (11.7%) than with neither condition (22.5%; P = 0.005)., Conclusions: In eyes in the CATT, VMT and VMA were infrequent. At baseline and follow-up, VMT or VMA were not associated with VA. Eyes with VMT or VMA treated as needed required on average 2 more injections over 2 years., (Copyright © 2015 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2015
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49. Author reply: To PMID 23337555.

Author

Hagstrom SA, Ying GS, Maguire MG, and Martin DF

Subjects
Female, Humans, Male, Angiogenesis Inhibitors therapeutic use, Complement C3 genetics, Macular Degeneration genetics, Polymorphism, Single Nucleotide, Proteins genetics, Serine Endopeptidases genetics
Published
2014
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50. Anterior chamber infiltrates associated with systemic lymphoma: report of two cases and review of the literature.

Author

O'Keefe JS, Sippy BD, Martin DF, Holden JT, and Grossniklaus HE

Subjects
Abdominal Neoplasms pathology, Adult, Biomarkers, Tumor analysis, Combined Modality Therapy, Fatal Outcome, Female, Flow Cytometry, Humans, Immunophenotyping, Lymphatic Metastasis, Lymphoma, Follicular chemistry, Lymphoma, Follicular therapy, Lymphoma, Non-Hodgkin chemistry, Lymphoma, Non-Hodgkin therapy, Male, Suppuration pathology, Anterior Chamber pathology, Eye Neoplasms secondary, Lymphoma, Follicular pathology, Lymphoma, Non-Hodgkin pathology
Abstract

Purpose: To describe the clinicopathologic features of two patients with systemic lymphoma who developed anterior chamber (AC) infiltrates of lymphoma cells., Design: Two case reports and literature review., Methods: The clinical and pathologic findings in two patients with AC infiltrates secondary to systemic B-cell lymphoma are reviewed., Main Outcome Measurements: Clinical observation and cytologic/flow cytometric examination of the infiltrate after AC aspiration., Results: One patient presented with uveal infiltration, an exudative retinal detachment and an AC infiltrate. Systemic evaluation revealed a follicular lymphoma involving several groups of lymph nodes. The second patient with a known history of abdominal lymphoma was found to have blurred vision, photophobia and an AC infiltrate. Flow cytometric analysis of the AC infiltrate in both patients showed phenotypes consistent with the patients' systemic lymphomas., Conclusions: A pseudohypopyon in an adult may represent either the initial manifestation or a later complication of systemic lymphoma, similar to what has been reported in acute leukemia.

Published
2002
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