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1. 24-Hour Intraocular Pressure Control with Fixed-dose Combination Brinzolamide 1%/Brimonidine 0.2%

Author

David Wirta, Robert N. Weinreb, Steve Burmaster, Robert D. Fechtner, Malik Y. Kahook, Xiangyi Meng, Jason Bacharach, and Douglas A. Hubatsch

Subjects
Intraocular pressure, medicine.medical_specialty, Supine position, genetic structures, business.industry, Brimonidine, Brinzolamide, Fixed-dose combination, Glaucoma, Ocular hypertension, medicine.disease, eye diseases, law.invention, Ophthalmology, Randomized controlled trial, law, medicine, sense organs, business, medicine.drug
Abstract

Purpose To determine the intraocular pressure (IOP)-lowering effect of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) over a 24-hour period. Design Prospective, multicenter, double-masked, parallel-group clinical trial conducted at 16 academic and nonacademic sites in the United States. Participants Subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT) aged ≥18 years with mean baseline IOP measurements in at least 1 eye of ≥21 and Methods Duplicate mean pneumatonometer IOP measurements were collected every 2 hours over a 24-hour period in controlled light conditions in overnight facilities. Daytime (8 am –8 pm ) and nocturnal (10 pm –6 am ) IOP measurements were collected in a sitting or supine position, respectively. Baseline 24-hour IOP was measured in untreated subjects after a washout (up to 4 weeks) and eligibility phase. After the baseline visit, participants were randomized 1:1 to receive masked BBFC or vehicle, 1 drop 3 times daily (8 am , 3 pm , and 10 pm ) for 4 weeks. At week 4, IOP measurements were repeated in both groups under the same conditions. Main Outcome Measure Mean change from baseline in 24-hour IOP at week 4. Results Of 125 participants randomized, 123 (98%; BBFC, n = 62; vehicle, n = 61) completed the study. No subjects randomized to BBFC discontinued the study. At week 4, BBFC-treated eyes had significantly reduced mean 24-hour IOP vs. vehicle (least squares mean difference [95% confidence interval]: −2.5 [−3.3, −1.7]; P pm , 12 am , and 6 am ; secondary end point). The frequency of adverse events was similar between treatment groups; in the BBFC arm, ocular hyperemia, corneal abrasion, and dysgeusia were the most frequently reported, consistent with events described in the drug label. Conclusions This large, multicenter study of 24-hour IOP control with BBFC met its primary end point; BBFC demonstrated significantly superior 24-hour IOP-lowering efficacy versus vehicle after 4 weeks of 3-times-daily treatment in subjects with OAG or OHT.

Published
2019
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3. Contributors

Author

Abtahi, Maryam, Adams, Wendy, Afshari, Natalie A., Agarwal, Anita, Agranat, Joshua S., Ajlan, Radwan S., Akhlaq, Anam, Al-Aswad, Lama, AlBayyat, Ghada, Albini, Thomas A., Ghoul, Ahmed Al, Al-Mohtaseb, Zaina, Alvi, Nishat P., Apple, David J., Aquino, Maria Cecilia, Arnold, Anthony C., Arnoldi, Kyle, Arshinoff, Steve A., Asbell, Penny A., Ashe, Stephen A., Asroui, Lara, Atebara, Neal H., Awh, Katherine C., Aylward, G. William, Bacci, Tommaso, Bakri, Sophie J., Balcer, Laura J., Balducci, Nicole, Barboni, Piero, Baş, Zeynep, Basu, Soumyava, Baumal, Caroline R., Bessette, Angela P., Bhatt, Nirali, Bhullar, Paramjit K., Binotti, William, Birch, Eileen E., Biswas, Jyotirmay, Bjerregaard, Robert William, Bose, Swaraj, Bouchard, Charles S., Boulton, Michael E., Bouremel, Yann, Brandt, James D., Brocchini, Steve, Brodie, Scott E., Brodsky, Michael C., Brooks, Cassandra, Brown, Aaron Christopher, Budenz, Donald L., Cantor, Louis B., Capo, Hilda, Capone, Antonio, Jr., Carruthers, Alastair, Carruthers, Jean D., Carter, Keith D., Chahal, Harinderpal, Chan, Chi-Chao, Chan, Jane W., Chang, Melinda Y., Chang, Stanley, Charteris, David G., Chee, Soon-Phaik, Chen, Masako, Chen, Michael Yipeng, Chen, Sien, Chen, Xuejing, Tec Kuan Chew, Paul, Chong, Jillian K., Chow, Clement C., Clarke, Jonathan C.K., Codère, François, Conner, Ian P., Soledad Cortina, Maria, Couch, Steven M., Coupland, Stuart G., Cowan, Claude, Craven, E. Randy, Cukras, Catherine A., Dagi, Linda, Dalvin, Lauren A., Damgaard, Iben Bach, Fatehali Damji, Karim, Das, Dipankar, DeBusk, Adam, Carlo, Talisa E. de, Coulon, Sara Jacob, Demer, Joseph Louis, Desai, Shilpa J., Dhaliwal, Deepinder K., Dhawlikar, Nisha, Diamond, Gary R., Diaz, Jose Daniel, Diniz, Daniel, Djenderedjian, Levon, Do, Anna Thanh Tam, Do, Diana V., Dolman, Peter J., Donahue, Sean P., Drenser, Kimberly A., Duffy, Kevin R., Duker, Jacob S., Duker, Jay S., Dupps, William J., Jr., Durairaj, Vikram D., Dutton, Jonathan J., Eliott, Dean, Engelbert, Michael, Enzor, Rikki S., Epstein, Aliza, Evans, Joshua W., Evans, Monica, Faia, Lisa J., Fallano, Katherine A., Farjo, Ayad A., Fernandez, Karen B., Fisher, Yale L., Fortun, Jorge A., Friedman, Deborah I., Friedman, Neil J., Fynn-Thompson, Nicoletta, Gadaria-Rathod, Neha, Garg, Sumit (Sam), Gayre, Gregg, Gedde, Steven, Geevarghese, Alexi, Ghosh, Saurabh, William Gigantelli, James, Goerlitz-Jessen, Mark, Goldberg, Ivan, Goldberg, Jeffrey L., Goldstein, Debra A., Goldstein, Michael H., Gonzales, John A., Gore, Charlotte, Granet, David B., Greven, Craig M., Greven, Margaret A., Gross, Ronald L., Gündüz, Ahmet Kaan, Gupta, Preeya K., Haller, Julia A., Hamrah, Pedram, Hannush, Sadeer B., Hardin, Joshua S., Harris, Alon, Hassan, Muhammad, Heier, Jeffrey S., Herndon, Leon W., Ho, Allen C., Ho, Joanne W., Honasoge, Avinash, Hood, Christopher T., Houghton, Odette, Houser, Kourtney, Howes, Frank W., Hsu, Jason, Hurwitz, Jeffrey J., Irochima, Francisco, Isteitiya, Jihad, Iyer, Geetha, Izak, Andrea M., Jackson, Kevin, Jacob, Soosan, Jacoba, Cris Martin P., Jacobs, Deborah S., Jampel, Henry D., Jampol, Lee M., Jeng-Miller, Karen, Jing-Wei Chen, John, Johnson, Mark W., Johnson, T. Mark, Johnstone, Murray, Kaakour, Abdul-Hadi, Kaehr, Mark M., Kahook, Malik Y., Kaiser, Peter K., Kalafatis, Nicholas, Kalevar, Ananda, Kane, Steven, Kang, Kai, Kanner, Elliott M., Kapoor, Saloni, Alton Kapusta, Michael, Karanjia, Rustum, Kardon, Randy H., Karp, Carol L., Kashani, Amir H., Kass, Michael A., Kataguiri, Paula, Kaufman, Paul L., D. Keenan, Jeremy, Kelly, Elaine, Kenyon, Kenneth R., Khandelwal, Sumitra, Tee Khaw, Peng, Kim, Ivana K., Kim, Terry, Kinori, Michael, Kiss, Szilárd, Kitchens, John W., Klein, Kendra, Ko, Narae, Koch, Douglas D., Kodati, Shilpa, Koh, Victor, Kohnen, Thomas, Konstas, Angelos A., Koo, Ellen, Lane, Stephen S., Lavin, Patrick J.M., Lavinsky, Fabio, Lawton, Andrew W., Le, Nhon T., Lee, Bonny, Lee, Crystal, Lee, Gregory D., Lee, Paul P, Han Lee, Rachel, Ann Lim, Dawn Ka, Lin, Tony, Lind, John T., Liu, Dan, Liu, Yao, Liyanage, Sidath E., Longmuir, Reid A., Lundström, Mats, N. Maamari, Robi, Mahjoub, Heba, Maloney, Maya H., Mamalis, Christina, Manche, Edward E., Mandava, Naresh, Martheswaran, Tanisha, Masket, Samuel, Mattox, Cynthia, Kevin McClatchey, Scott, McLeod, Stephen D., McMillan, Brian D., McNab, Alan A., Mehra, Ankur, Mehta, Jodhbir S., Mejia-Vergara, Alvaro J., Mejico, Luis J., Mekhail, Joseph, N. Mercer, Ryan, Mian, Shahzad I., Mieler, William F., Miller, Kyle E., Mirza, Rukhsana G., Misra, Poonam, Mititelu, Mihai, Mohammed, Taariq, Moorthy, Ramana S., Morkin, Melina I., Moshfeghi, Andrew A., Moshirfar, Majid, Moss, Heather E., Moster, Mark L., Muhtaseb, Ruba, Muir, Kelly W., Neff, Ann G., Nerad, Jeffrey A., Ng, Caleb C., Nguyen, Annie, Nikpoor, Neda, Nosé, Ricardo, Okada, Annabelle A., Datoo O'Keefe, Ghazala A., Olson, Jeffrey L., Olver, Jane M., Örge, Faruk H., Packard, Richard, Packer, Mark, Panarelli, Joseph, Pandey, Suresh K., Parikh, Vishal S., Pasha, Hamza, Pasquale, Louis R., Patel, Palak, Patel, Sarju S., Patel, Shaila R., Patel, Vivek R., Pavesio, Carlos, Perez, Victor L., Phillips, Lauren T., Piltz-Seymour, Jody R., Piva, Alfio P., Presland, Andrew H., Price, Francis W., Price, Marianne O., Quiros, Peter A., Rachitskaya, Aleksandra, Rahmani, Safa, Ramulu, Pradeep Y., Randleman, J. Bradley, Rao, Narsing A., Rao, Naveen K., Rao, P. Kumar, Rao, Rajesh C., Rathinam, Sivakumar, Read, Russell W., Reed, Donovan, Vinícius Saito Regatieri, Caio, Regillo, Carl D., Reichel, Elias, Reighard, Chelsea L., Richard, Alyse, Ringeisen, Alexander, Ritch, Robert, Robbins, Shira L., M. Rocha, Karolinne, Rodger, Damien C., Roh, Miin, Rosado-Adames, Noel, Rowe, Lucas W., Rubenstein, Jonathan B., Rubin, Richard M., Rubsamen, Patrick E., Saadati, Hossein G., Sadun, Alfredo A., Saeedi, Osamah, Sajjad, Ahmar, Salchow, Daniel J., Salim, Sarwat, Salongcay, Recivall P., Sandhu, Simrenjeet, Santhiago, Marcony R., Satija, Celine E., M. Schallhorn, Julie, Schmitt, Melanie, Schor, Paulo, Schroeder, Richard, Schubert, Hermann D., Schuman, Joel S., Schwartz, Gary S., Sen, H. Nida, Shah, Gaurav K., Shah, Ravi, Shields, Carol L., Shields, Jerry A., Shildkrot, Yevgeniy (Eugene), Shingleton, Bradford J., Shtein, Roni M., Shu-Wen Chan, Nicole, Shultz, Ryan W., Sieck, Erin, Siesky, Brent, Sieving, Paul A., S. Silva, Paolo, Simmons, Kirsten, Skondra, Dimitra, Smiddy, William E., Somogyi, Marie, Soong, H. Kaz, Soukiasian, Sarkis H., Spoor, Thomas C., Srinivasan, Bhaskar, Srivastava, Sunil K., Starnes, Taylor W., Starr, Matthew R., Steel, David H., Steigleman, W. Allan, Stein, Joshua D., Stepien, Kimberly E., Stevens, Dylan V., Strominger, Mitchell B., Sugar, Alan, Sugar, Joel, Suh, Donny W., Sun, Michelle, Sun, Yang, Sychev, Yevgeniy V., Tai, Tania, Tan, James C., Tanenbaum, Myron, Tasman, William, Tassignon, Marie-José B., Testi, Ilaria, Thall, Edmond H., Thanos, Aristomenis, Theophanous, Christos N., Thornton, Sarah, Tingey, David P., Todorich, Bozho, Tompson, Stuart W., Toy, Brian, Tsai, James C., Tsai, Julie, Tucker, Nancy, Tuli, Sonal S., Valerio, Gabriel S., Vargason, Caroline W., Vasaiwala, Roshni A., Vitor Vasconcelos-Santos, Daniel, Vaughn, Gregory J., Venkateswaran, Nandini, Vinod, Kateki, Vislisel, Jesse M., Vrcek, Ivan, Walton, David S., Wang, Li, Wang, Michelle Y., Wang, Robert C., Waring IV, George O., Weikert, Mitchell P., Werner, Liliana, Wevill, Mark, Wiggs, Janey L., Williams, Andrew M., Williams, George A., Witmer, Matthew T., Wollstein, Gadi, Woodward, Maria A., Wride, Nicholas K., Wu, Albert Y., Yaghy, Antonio, Young, Joshua A., Zaguia, Fatma, Zein, Wadih M., and Zhu, Ivy

Published
2023
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6. Ability of Bottle Cap Color to Facilitate Accurate Patient–Physician Communication Regarding Medication Identity in Patients with Glaucoma

Author

Pradeep Y. Ramulu, David S. Friedman, Guadalupe Villarreal, Pujan Dave, and Malik Y. Kahook

Subjects
Intraocular pressure, medicine.medical_specialty, Visual acuity, genetic structures, medicine.diagnostic_test, business.industry, Color vision, Brimonidine, Brinzolamide, Glaucoma, medicine.disease, Ophthalmology, chemistry.chemical_compound, chemistry, medicine, Optometry, Color perception test, Latanoprost, medicine.symptom, business, medicine.drug
Abstract

Purpose To determine the accuracy of patient–physician communication regarding topical ophthalmic medication use based on bottle cap color, particularly among individuals who may have acquired color vision deficiency from glaucoma. Design Cross-sectional, clinical study. Participants Patients aged ≥18 years with primary open-angle, primary angle-closure, pseudoexfoliation, or pigment dispersion glaucoma, bilateral visual acuity of ≥20/400, and no concurrent conditions that may affect color vision. Methods A total of 100 patients provided color descriptions of 11 distinct medication bottle caps. Color descriptors were then presented to 3 physicians. Physicians matched each color descriptor to the medication they thought the descriptor was describing. Main Outcome Measures Frequency of patient–physician agreement, occurring when all 3 physicians accurately matched the color descriptor to the correct medication. Multivariate regression models evaluated whether patient–physician agreement decreased with degree of better-eye visual field (VF) damage, color descriptor heterogeneity, or color vision deficiency, as determined by the Hardy–Rand–Rittler (HRR) score and Lanthony D15 color confusion index (D15 CCI). Results Subjects had a mean age of 69 (±11) years, with VF mean deviation of −4.7 (±6.0) and −10.9 (±8.4) decibels (dB) in the better- and worse-seeing eyes, respectively. Patients produced 102 unique color descriptors to describe the colors of the 11 bottle caps. Among individual patients, the mean number of medications demonstrating agreement was 6.1/11 (55.5%). Agreement was less than 15% for 4 medications (prednisolone acetate [generic], betaxolol HCl [Betoptic; Alcon Laboratories Inc., Fort Worth, TX], brinzolamide/brimonidine [Simbrinza; Alcon Laboratories Inc.], and latanoprost [Xalatan; Pfizer, Inc., New York, NY]). Lower HRR scores and higher D15 CCI (both indicating worse color vision) were associated with greater VF damage ( P P P = 0.007). Conclusions Physician understanding of patient medication use based solely on bottle cap color is frequently incorrect, particularly in patients with glaucoma who may have color vision deficiency. Errors based on communication using bottle cap color alone may be common and could lead to confusion and harm.

Published
2015
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7. 24-Hour Intraocular Pressure Control with Fixed-dose Combination Brinzolamide 1%/Brimonidine 0.2%: A Multicenter, Randomized Trial

Author

Robert N, Weinreb, Jason, Bacharach, Robert D, Fechtner, Malik Y, Kahook, David, Wirta, Steve, Burmaster, Xiangyi, Meng, and Douglas A, Hubatsch

Subjects
Male, Sulfonamides, Thiazines, Middle Aged, Double-Blind Method, Brimonidine Tartrate, Humans, Drug Therapy, Combination, Female, Ocular Hypertension, Prospective Studies, Carbonic Anhydrase Inhibitors, Antihypertensive Agents, Glaucoma, Open-Angle, Intraocular Pressure, Aged
Abstract

To determine the intraocular pressure (IOP)-lowering effect of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) over a 24-hour period.Prospective, multicenter, double-masked, parallel-group clinical trial conducted at 16 academic and nonacademic sites in the United States.Subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT) aged ≥18 years with mean baseline IOP measurements in at least 1 eye of ≥21 and28 mmHg.Duplicate mean pneumatonometer IOP measurements were collected every 2 hours over a 24-hour period in controlled light conditions in overnight facilities. Daytime (8 am-8 pm) and nocturnal (10 pm-6 am) IOP measurements were collected in a sitting or supine position, respectively. Baseline 24-hour IOP was measured in untreated subjects after a washout (up to 4 weeks) and eligibility phase. After the baseline visit, participants were randomized 1:1 to receive masked BBFC or vehicle, 1 drop 3 times daily (8 am, 3 pm, and 10 pm) for 4 weeks. At week 4, IOP measurements were repeated in both groups under the same conditions.Mean change from baseline in 24-hour IOP at week 4.Of 125 participants randomized, 123 (98%; BBFC, n = 62; vehicle, n = 61) completed the study. No subjects randomized to BBFC discontinued the study. At week 4, BBFC-treated eyes had significantly reduced mean 24-hour IOP vs. vehicle (least squares mean difference [95% confidence interval]: -2.5 [-3.3, -1.7]; P0.001); daytime (-3.4 [-4.3, -2.6]; P0.001) and nocturnal (-1.2 [-2.3, 0.0]; P = 0.053) reductions were observed. Mean change from baseline was significantly different between BBFC- and vehicle-treated eyes at all daytime points and 3 of 5 nocturnal time points (10 pm, 12 am, and 6 am; secondary end point). The frequency of adverse events was similar between treatment groups; in the BBFC arm, ocular hyperemia, corneal abrasion, and dysgeusia were the most frequently reported, consistent with events described in the drug label.This large, multicenter study of 24-hour IOP control with BBFC met its primary end point; BBFC demonstrated significantly superior 24-hour IOP-lowering efficacy versus vehicle after 4 weeks of 3-times-daily treatment in subjects with OAG or OHT.

Published
2018

9. Special Commentary: Food and Drug Administration and American Academy of Ophthalmology Sponsored

Author

John P. Berdahl, Tina Kiang, Thomas A. Oetting, Eva Rorer, Don Calogero, Malik Y. Kahook, Michelle E. Tarver, Anne L. Coleman, Malvina B. Eydelman, Gene Hilmantel, and Flora Lum

Subjects
Food and drug administration, Cataract extraction, Ophthalmology, medicine.medical_specialty, Extended depth of focus, Intraocular lenses, business.industry, medicine, Optometry, business
Published
2015
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10. Glaucoma Patient Treatment Preferences

Author

Catherine M. Marando, Jeffrey R. SooHoo, Leonard K. Seibold, Liliya Golas, Pradeep Y. Ramulu, Malik Y. Kahook, and Mina B. Pantcheva

Subjects
Male, Intraocular pressure, medicine.medical_specialty, Administration, Topical, Treatment outcome, MEDLINE, Glaucoma, 03 medical and health sciences, 0302 clinical medicine, Filtering surgery, medicine, Humans, Patient treatment, Antihypertensive Agents, Intraocular Pressure, Aged, business.industry, Patient Preference, medicine.disease, Patient preference, Surgery, Ophthalmology, Ophthalmic solutions, Treatment Outcome, Filtering Surgery, 030221 ophthalmology & optometry, Female, Ophthalmic Solutions, business, 030217 neurology & neurosurgery
Published
2015

11. List of Contributors

Author

Acera, Erika C., Afshari, Natalie A., Agarwal, Anita, Agranat, Joshua S., Ajlan, Radwan S., Akhlaq, Anam, Albini, Thomas A., Al-Ghoul, Ahmed, Ali, Ferhina S., Alió, Jorge L., Allemann, Norma, Allen, David, Allman, Keith G., Alvi, Nishat P., Ang, Leonard P.K., Apple, David J., Aquino, Maria Cecilia D., Arnold, Anthony C., Arshinoff, Steve A., Asbell, Penny A., Assil, Kerry K., Atebara, Neal H., Augsburger, James J., Aylward, G. William, Azar, Dimitri T., Bakri, Sophie J., Balcer, Laura J., Balducci, Nicole, Barboni, Piero, Barnett, Cullen J., Basu, Soumyava, Batta, Priti, Baumal, Caroline R., Bearelly, Srilaxmi, Berry, Jesse L., Bessette, Angela P., Bhatt, Nirali, Birdsong, Orry C., Biswas, Jyotirmay, Bodaghi, Bahram, Bose, Swaraj, Bouchard, Charles S., Boulton, Michael E., Brandt, James D., Brodie, Scott E., Brodsky, Michael C., Brooks, Cassandra C., Brumm, Matthew V., Budenz, Donald L., Bussel, Igor I., Cantor, Louis B., Capó, Hilda, Capone, Antonio, Jr, Carruthers, Alastair, Carruthers, Jean, Carter, Keith D., Caruso, Rafael C., Chahal, Harinderpal S., Chamon, Wallace, Chan, Chi-Chao, Chang, Melinda Y., Chang, Stanley, Chang, Victoria S., Charteris, David G., Chee, Soon-Phaik, Chen, John J., Chen, Xuejing, Chew, Paul T.K., Chiu, Bing, Chow, Clement C., Civan, Mortimer M., Clark, Abbot (Abe), Clarke, Jonathan C.K., Codère, François, Conner, Ian P., Coombs, Peter, Corrêa, Zélia M., Couch, Steven M., Coupland, Stuart G., Cowan, Claude L., Jr, Craven, E. Randy, Cukras, Catherine A., Dagi, Linda R., Dahan, Elie, Damgaard, Iben Bach, Damji, Karim F., Das, Dipankar, DeBusk, Adam, de la Cruz, Jose, Demer, Joseph L., Desai, Shilpa J., Dhaliwal, Deepinder K., Diamond, Gary R., Diniz, Daniel, Do, Diana V., Dolman, Peter J., Donahue, Sean P., Dortzbach, Richard K., Drenser, Kimberly A., Duker, Jacob S., Duker, Jay S., Durairaj, Vikram D., Dutton, Jonathan J., Edgington, Bryan, Eggers, Howard M., Eliott, Dean, Ellis, George S., Jr, Engelbert, Michael, Englander, Miriam, Esmaeli, Bita, Evans, Joshua W., Evans, Monica, Fahd, Daoud S., Faia, Lisa J., Fallano, Katherine A., Farjo, Ayad A., Feinstein, Eric, Fernandez, Karen B., Fisher, Yale L., Fishman, Gerald A., Fortun, Jorge A., Fragoso, Veronica Vargas, Freeman, Nicola, Friedman, David S., Friedman, Deborah I., Friedman, Neil J., Fynn-Thompson, Nicoletta, Gadaria-Rathod, Neha, Garcia-Zalisnak, Debora E., Gayre, Gregg S., Gedde, Steven J., Gery, Igal, Ghanem, Ramon C., Ghanem, Vinícius C., Ghosh, Saurabh, Gibbons, Allister, Gigantelli, James W., Giri, Pushpanjali, Goldberg, Ivan, Goldberg, Jeffrey L., Goldstein, Debra A., Goldstein, Michael H., Gonzales, John A., Granet, David B., Gray, Matthew J., Green, Kyle M., Greven, Craig M., Greven, Margaret A., Gross, Josh C., Gross, Ronald L., Grover, Sandeep, Guercio, Jason R., Gueudry, Julie, Gündüz, Ahmet Kaan, Hallak, Joelle A., Haller, Julia A., Hamrah, Pedram, Hardten, David R., Harris, Alon, Heier, Jeffrey S., Herndon, Leon W., Jr, Ho, Allen C., Hood, Christopher T., Hou, Joshua H., Houghton, Odette M., Houser, Kourtney, Howes, Frank W., Hsu, Jason, Hurwitz, Jeffrey J., Irochima, Francisco, Isteitiya, Jihad, Izak, Andrea M., Jacobs, Deborah S., Jain, Sandeep, Jampel, Henry D., Jampol, Lee M., Jap, Aliza, Johnson, Chris A., Johnson, Mark W., Johnson, T. Mark, Kaehr, Mark M., Kahook, Malik Y., Kaiser, Peter K., Kalarn, Sachin P., Kalevar, Ananda, Kane, Steven, Kanner, Elliott M., Kaplowitz, Kevin, Kapusta, Michael A., Karanjia, Rustum, Kardon, Randy H., Karp, Carol L., Kashani, Amir H., Kass, Michael A., Kataguiri, Paula, Katz, L. Jay, Kaufman, Paul L., Keenan, Jeremy D., Kenyon, Kenneth R., Khaw, Peng Tee, Kim, Gene, Kim, Ivana K., Kimura, Alan E., Kinori, Michael, Kirwan, Caitriona, Kiss, Szilárd, Kitchens, John W., Klein, Kendra, Koch, Douglas D., Koh, Victor T.C., Kohnen, Thomas, Koustenis, Andrew, Lane, Stephen S., Lavin, Patrick J.M., Lavinsky, Fabio, Lawton, Andrew W., Lee, Bryan S., Lee, Daniel, Lee, Gregory D., Lee, Olivia L., Lee, Paul P., Lee, Richard M.H., Lim, Dawn K.A., Lim, Jennifer I., Lim, Ridia, Lin, Tony K.Y., Lind, John T., Liu, Yao, Liyanage, Sidath E., Lockwood, Alastair J., Loewen, Nils A., Longmuir, Reid A., Lopez, Pedro F., Lundström, Mats, Maamari, Robi N., Madu, Assumpta, Maloney, Maya H., Mandava, Naresh, Marmor, Michael F., Mathura, Jeevan R., Jr, Mattox, Cynthia, McClatchey, Scott K., McLeod, Stephen D., McMillan, Brian D., McNab, Alan A., Mehta, Jodhbir S., Mejico, Luis J., Mercado, Carolina L., Mian, Shahzad I., Mieler, William F., Miller, David, Miller, Kyle E., Mimura, Tatsuya, Mirza, Rukhsana G., Mititelu, Mihai, Moorthy, Ramana S., Moshfeghi, Andrew A., Moshirfar, Majid, Moss, Heather E., Moster, Mark L., Muir, Kelly W., Neff, Ann G., Nerad, Jeffrey A., Nikpoor, Neda, Noecker, Robert J., Nosé, Ricardo, Okada, Annabelle A., O'Keefe, Michael, Olson, Jeffrey L., Olver, Jane M., Opalinski, Yvonne A.V., Örge, Faruk H., Packer, Mark, Pandey, Suresh K., Parikh, Vishal S., Pasquale, Louis R., Patel, Sarju S., Patel, Vivek R., Pavesio, Carlos E., Perez, Victor L., Perez-Straziota, Claudia E., Phillips, Lauren T., Piltz-Seymour, Jody R., Piva, Alfio P., Podbielski, Dominik W., Pondelis, Nicolas J., Price, Francis W., Jr, Price, Marianne O., Pritchard, Cindy, Quiros, Peter A., Rachitskaya, Aleksandra V., Ramulu, Pradeep Y., Randleman, J. Bradley, Rao, Narsing A., Rao, Naveen K., Rao, P. Kumar, Rao, Rajesh C., Rathinam, Sivakumar, Read, Russell W., Saito Regatieri, Caio Vinicius, Regillo, Carl D., Reichel, Elias, Rhee, Douglas J., Ringeisen, Alexander L., Ritch, Robert, Robbins, Shira L., Rodger, Damien C., Roh, Miin, Roh, Shiyoung, Rosado-Adames, Noel, Rosen, Emanuel S., Rubenstein, Jonathan B., Rubin, Richard M., Rubin, Steven E., Rubsamen, Patrick E., Rupp, Jason D., Saadati, Hossein G., Sadun, Alfredo A., Saeedi, Osamah J., Salchow, Daniel J., Salim, Sarwat, Samuelson, Thomas W., Sandhu, Simrenjeet, Santhiago, Marcony R., Savini, Giacomo, Sayed-Ahmed, Ibrahim O., Scheffler, Amy C., Schor, Paulo, Schubert, Hermann D., Schuman, Joel S., Schwartz, Gary S., Sebag, J., Sebrow, Dov B., Sen, H. Nida, Shah, Gaurav K., Shields, Carol L., Shildkrot, Yevgeniy (Eugene), Shingleton, Bradford J., Shtein, Roni M., Shultz, Ryan W., Sierra, Patricia B., Siesky, Brent, Sieving, Paul A., Skondra, Dimitra, Small, Kent W., Smiddy, William E., Somogyi, Marie, Soong, H. Kaz, Soukiasian, Sarkis H., Spaide, Richard F., Spektor, Tatyana, Spoor, Thomas C., Srivastava, Sunil K., Stagg, Brian C., Steel, David H.W., Stein, Joshua D., Strominger, Mitchell B., Sugar, Alan, Sugar, Joel, Sychev, Yevgeniy V., Tania Tai, Tak Yee, Tan, James C., Tanenbaum, Myron, Taneri, Suphi, Tasman, William, Telander, David G., Thall, Edmond H., Thanos, Aristomenis, Theophanous, Christos N., Thomas, Benjamin J., Thulasi, Praneetha, Tibbetts, Michael D., Tingey, David P., Tobaigy, Faisal M., Todorich, Bozho, Tompson, Stuart W., Tsai, James C., Tsai, Julie H., Tucker, Nancy, Tuli, Sonal S., Vargason, Caroline W., Vasaiwala, Roshni A., Vasconcelos-Santos, Daniel Vitor, Vaughn, Gregory J., Venkat, Arthi, Villarreal, Guadalupe, Jr, Vinod, Kateki, Vislisel, Jesse M., Vrcek, Ivan, Wadia, Hormuz P., Walker, Brian D., Walton, David S., Wang, Li, Wang, Michelle Y., Wang, Robert C., Wax, Martin, Weinstein, Joel M., Weiter, John J., Werner, Liliana, Wevill, Mark, Wiggs, Janey L., Williams, Andrew M., Williams, George A., Witmer, Matthew T., Wollstein, Gadi, Woodward, Maria A., Wride, Nicholas K., Wu, Albert, Xu, David, Young, Joshua A., Yung, Edward S., Yu-Wai-Man, Cynthia, Zein, Wadih M., and Zhu, Ivy

Published
2019
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12. The Utility of Cap Color and Bottle Characteristics for Topical Glaucoma Therapy

Author

Malik Y. Kahook, Leonard K. Seibold, Mina B. Pantcheva, Jeffrey R. SooHoo, Pradeep Y. Ramulu, and Catherine M. Marando

Subjects
Adult, Male, medicine.medical_specialty, business.product_category, Administration, Topical, Glaucoma, Medication Adherence, Surveys and Questionnaires, Ophthalmology, Bottle, Humans, Medication Errors, Medicine, Antihypertensive Agents, Drug Packaging, Aged, Aged, 80 and over, business.industry, Middle Aged, medicine.disease, Cross-Sectional Studies, Female, Ophthalmic Solutions, business
Published
2015
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13. Glaucoma Patient Treatment Preferences

Author

SooHoo, Jeffrey R., primary, Golas, Liliya, additional, Marando, Catherine M., additional, Seibold, Leonard K., additional, Pantcheva, Mina B., additional, Ramulu, Pradeep Y., additional, and Kahook, Malik Y., additional

Published
2016
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