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17 results on '"Lotery, Andrew J."'

2. The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts

Author

Madjedi, Kian M., primary, Stuart, Kelsey V., additional, Chua, Sharon Y.L., additional, Luben, Robert N., additional, Warwick, Alasdair, additional, Pasquale, Louis R., additional, Kang, Jae H., additional, Wiggs, Janey L., additional, Lentjes, Marleen A.H., additional, Aschard, Hugues, additional, Sattar, Naveed, additional, Foster, Paul J., additional, Khawaja, Anthony P., additional, Chia, Mark, additional, Do, Ron, additional, Kastner, Alan, additional, Kim, Jihye, additional, Montesano, Giovanni, additional, Atan, Denize, additional, Aslam, Tariq, additional, Barman, Sarah A., additional, Barrett, Jenny H., additional, Bishop, Paul, additional, Blows, Peter, additional, Bunce, Catey, additional, Carare, Roxana O., additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Crabb, David P., additional, Cumberland, Philippa M., additional, Day, Alexander, additional, Desai, Parul, additional, Dhillon, Bal, additional, Dick, Andrew D., additional, Egan, Cathy, additional, Ennis, Sarah, additional, Foster, Paul, additional, Fruttiger, Marcus, additional, Gallacher, John E.J., additional, Garway-Heath, David F., additional, Gibson, Jane, additional, Gore, Dan, additional, Guggenheim, Jeremy A., additional, Hammond, Chris J., additional, Hardcastle, Alison, additional, Harding, Simon P., additional, Hogg, Ruth E., additional, Hysi, Pirro, additional, Keane, Pearse A., additional, Khaw, Sir Peng T., additional, Lascaratos, Gerassimos, additional, Lotery, Andrew J., additional, Macgillivray, Tom, additional, Mackie, Sarah, additional, Martin, Keith, additional, McGaughey, Michelle, additional, McGuinness, Bernadette, additional, McKay, Gareth J., additional, McKibbin, Martin, additional, Mitry, Danny, additional, Moore, Tony, additional, Morgan, James E., additional, Muthy, Zaynah A., additional, O’Sullivan, Eoin, additional, Owen, Chris G., additional, Patel, Praveen, additional, Paterson, Euan, additional, Peto, Tunde, additional, Petzold, Axel, additional, Rahi, Jugnoo S., additional, Rudnikca, Alicja R., additional, Self, Jay, additional, Sivaprasad, Sobha, additional, Steel, David, additional, Stratton, Irene, additional, Strouthidis, Nicholas, additional, Sudlow, Cathie, additional, Thomas, Dhanes, additional, Trucco, Emanuele, additional, Tufail, Adnan, additional, Vitart, Veronique, additional, Vernon, Stephen A., additional, Viswanathan, Ananth C., additional, Williams, Cathy, additional, Williams, Katie, additional, Woodside, Jayne V., additional, Yates, MaxM., additional, Yip, Jennifer, additional, and Zheng, Yalin, additional

Published
2022
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3. The Complement Component 5 Gene and Age-Related Macular Degeneration

Author

Baas, Dominique C., Ho, Lintje, Ennis, Sarah, Merriam, Joanna E., Tanck, Michael W.T., Uitterlinden, André G., de Jong, Paulus T.V.M., Cree, Angela J., Griffiths, Helen L., Rivadeneira, Fernando, Hofman, Albert, van Duijn, Cornelia, Smith, R. Theodore, Barile, Gaetano R., Gorgels, Theo G.M.F., Vingerling, Johannes R., Klaver, Caroline C.W., Lotery, Andrew J., Allikmets, Rando, and Bergen, Arthur A.B.

Published
2010
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4. Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank

Author

Zebardast, Nazlee, primary, Sekimitsu, Sayuri, additional, Wang, Jiali, additional, Elze, Tobias, additional, Gharahkhani, Puya, additional, Cole, Brian S., additional, Lin, Michael M., additional, Segrè, Ayellet V., additional, Wiggs, Janey L., additional, Aung, Tin, additional, Craig, Jamie E., additional, Cheng, Ching-Yu, additional, Cooke Bailey, Jessica N., additional, Cree, Angela J., additional, Foster, Paul J., additional, Hammond, Christopher J., additional, Hewitt, Alex W., additional, Höhn, René, additional, Hysi, Pirro G., additional, Iglesias, Adriana I., additional, Jonas, Jost B., additional, Klaver, Caroline C.W., additional, Khawaja, Anthony P., additional, Khor, Chiea Chuen, additional, Lotery, Andrew J., additional, MacGregor, Stuart, additional, Mackey, David A., additional, Ong, Jue Sheng, additional, Mitchell, Paul, additional, Pasquale, Louis R., additional, Pang, ChiPui, additional, Pasutto, Francesca, additional, Pfeiffer, Norbert, additional, Segre, Ayellet V., additional, van Duijn, Cornelia M., additional, Viswanathan, Ananth C., additional, Vitart, Veronique, additional, Vithana, Eranga N., additional, Wojciechowski, Robert, additional, Young, Terri L., additional, Wong, Tien Yin, additional, and Yazar, Seyhan, additional

Published
2021
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5. Two-Year Results of the Phase 3 Randomized Controlled Study of Abicipar in Neovascular Age-Related Macular Degeneration

Author

Khurana, Rahul N., primary, Kunimoto, Derek, additional, Yoon, Young Hee, additional, Wykoff, Charles C., additional, Chang, Andrew, additional, Maturi, Raj K., additional, Agostini, Hansjürgen, additional, Souied, Eric, additional, Chow, David R., additional, Lotery, Andrew J., additional, Ohji, Masahito, additional, Bandello, Francesco, additional, Belfort, Rubens, additional, Li, Xiao-Yan, additional, Jiao, Jenny, additional, Le, Grace, additional, Kim, Kimmie, additional, Schmidt, Werner, additional, and Hashad, Yehia, additional

Published
2021
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6. An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity

Author

Qassim, Ayub, primary, Souzeau, Emmanuelle, additional, Siggs, Owen M., additional, Hassall, Mark M., additional, Han, Xikun, additional, Griffiths, Helen L., additional, Frost, N. Andrew, additional, Vallabh, Neeru A., additional, Kirwan, James F., additional, Menon, Geeta, additional, Cree, Angela J., additional, Galanopoulos, Anna, additional, Agar, Ashish, additional, Healey, Paul R., additional, Graham, Stuart L., additional, Landers, John, additional, Casson, Robert J., additional, Gharahkhani, Puya, additional, Willoughby, Colin E., additional, Hewitt, Alex W., additional, Lotery, Andrew J., additional, MacGregor, Stuart, additional, and Craig, Jamie E., additional

Published
2020
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7. Comparison of Associations with Different Macular Inner Retinal Thickness Parameters in a Large Cohort

Author

Khawaja, Anthony P., primary, Chua, Sharon, additional, Hysi, Pirro G., additional, Georgoulas, Stelios, additional, Currant, Hannah, additional, Fitzgerald, Tomas W., additional, Birney, Ewan, additional, Ko, Fang, additional, Yang, Qi, additional, Reisman, Charles, additional, Garway-Heath, David F., additional, Hammond, Chris J., additional, Khaw, Peng T., additional, Foster, Paul J., additional, Patel, Praveen J., additional, Strouthidis, Nicholas, additional, Atan, Denize, additional, Aslam, Tariq, additional, Barman, Sarah A., additional, Barrett, Jenny H., additional, Bishop, Paul, additional, Blows, Peter, additional, Bunce, Catey, additional, Carare, Roxana O., additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chua, Sharon Y.L., additional, Crabb, David P., additional, Cumberland, Philippa M., additional, Day, Alexander, additional, Desai, Parul, additional, Dhillon, Bal, additional, Dick, Andrew D., additional, Egan, Cathy, additional, Ennis, Sarah, additional, Foster, Paul, additional, Fruttiger, Marcus, additional, Gallacher, John E.J., additional, Gibson, Jane, additional, Gore, Dan, additional, Guggenheim, Jeremy A., additional, Hardcastle, Alison, additional, Harding, Simon P., additional, Hogg, Ruth E., additional, Hysi, Pirro, additional, Keane, Pearse A., additional, Khaw, Sir Peng T., additional, Khawaja, Anthony P., additional, Lascaratos, Gerassimos, additional, Lotery, Andrew J., additional, Macgillivray, Tom, additional, Mackie, Sarah, additional, Martin, Keith, additional, McGaughey, Michelle, additional, McGuinness, Bernadette, additional, McKay, Gareth J., additional, McKibbin, Martin, additional, Mitry, Danny, additional, Moore, Tony, additional, Morgan, James E., additional, Muthy, Zaynah A., additional, O’Sullivan, Eoin, additional, Owen, Chris G., additional, Patel, Praveen, additional, Paterson, Euan, additional, Peto, Tunde, additional, Petzold, Axel, additional, Rahi, Jugnoo S., additional, Rudnikca, Alicja R., additional, Self, Jay, additional, Sivaprasad, Sobha, additional, Steel, David, additional, Stratton, Irene, additional, Sudlow, Cathie, additional, Thomas, Dhanes, additional, Trucco, Emanuele, additional, Tufail, Adnan, additional, Vitart, Veronique, additional, Vernon, Stephen A., additional, Viswanathan, Ananth C., additional, Williams, Cathy, additional, Williams, Katie, additional, Woodside, Jayne V., additional, Yates, Max M., additional, Yip, Jennifer, additional, and Zheng, Yalin, additional

Published
2020
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8. Associations with Corneal Hysteresis in a Population Cohort

Author

Zhang, Bing, primary, Shweikh, Yusrah, additional, Khawaja, Anthony P., additional, Gallacher, John, additional, Bauermeister, Sarah, additional, Foster, Paul J., additional, Aslam, Tariq, additional, Barman, Sarah A., additional, Barrett, Jenny H., additional, Bishop, Paul, additional, Blows, Peter, additional, Bunce, Catey, additional, Carare, Roxana O., additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chua, Sharon Y.L., additional, Crabb, David P., additional, Cumberland, Philippa M., additional, Day, Alexander, additional, Desai, Parul, additional, Dhillon, Bal, additional, Dick, Andrew D., additional, Egan, Cathy, additional, Ennis, Sarah, additional, Foster, Paul, additional, Fruttiger, Marcus, additional, Gallacher, John E.J., additional, Garway-Heath, David F., additional, Gibson, Jane, additional, Gore, Dan, additional, Guggenheim, Jeremy A., additional, Hammond, Chris J., additional, Hardcastle, Alison, additional, Harding, Simon P., additional, Hogg, Ruth E., additional, Hysi, Pirro, additional, Keane, Pearse A., additional, Khaw, Sir Peng T., additional, Lascaratos, Gerassim dos, additional, Lotery, Andrew J., additional, Macgillivray, Tom, additional, Mackie, Sarah, additional, Martin, Keith, additional, McGaughey, Michelle, additional, McGuinness, Bernadette, additional, McKay, Gareth J., additional, McKibbin, Martin, additional, Mitry, Danny, additional, Moore, Tony, additional, Morgan, James E., additional, Muthy, Zaynah A., additional, O’Sullivan, Eoin, additional, Owen, Chris G., additional, Patel, Praveen, additional, Paterson, Euan, additional, Peto, Tunde, additional, Petzold, Axel, additional, Rahi, Jugnoo S., additional, Rudnikca, Alicja R., additional, Self, Jay, additional, Sivaprasad, Sobha, additional, Steel, FRCOphth, David, additional, Stratton, Irene, additional, Strouthidis, Nicholas, additional, Sudlow, Cathie, additional, Thomas, Dhanes, additional, Trucco, Emanuele, additional, Tufail, Adnan, additional, Vitart, Veronique, additional, Vernon, Stephen A., additional, Viswanathan, Ananth C., additional, Williams, Cathy, additional, Williams, Katie, additional, Woodside, Jayne V., additional, Yates, Max M., additional, Yip, Jennifer, additional, and Zheng, Yalin, additional

Published
2019
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9. Associations with Retinal Pigment Epithelium Thickness Measures in a Large Cohort

Author

Ko, Fang, primary, Foster, Paul J., additional, Strouthidis, Nicholas G., additional, Shweikh, Yusrah, additional, Yang, Qi, additional, Reisman, Charles A., additional, Muthy, Zaynah A., additional, Chakravarthy, Usha, additional, Lotery, Andrew J., additional, Keane, Pearse A., additional, Tufail, Adnan, additional, Grossi, Carlota M., additional, and Patel, Praveen J., additional

Published
2017
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10. First-Year Visual Acuity Outcomes of Providing Aflibercept According to the VIEW Study Protocol for Age-Related Macular Degeneration

Author

Talks, James S., primary, Lotery, Andrew J., additional, Ghanchi, Faruque, additional, Sivaprasad, Sobha, additional, Johnston, Robert L., additional, Patel, Nishal, additional, McKibbin, Martin, additional, Bailey, Clare, additional, Mahmood, Sajjad, additional, Lobo, Aires, additional, Paul, Bobby, additional, Kashif, Qureshi, additional, Santiago, Cynthia, additional, Walters, Gavin, additional, Tahir, Mohamed, additional, and Mushtaq, Bushra, additional

Published
2016
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12. Ranibizumab in Myopic Choroidal Neovascularization: The 12-Month Results from the REPAIR Study

Author

Tufail, Adnan, primary, Narendran, Nirodhini, additional, Patel, Praveen J., additional, Sivaprasad, Sobha, additional, Amoaku, Winfried, additional, Browning, Andrew C., additional, Osoba, Olayinka, additional, Gale, Richard, additional, George, Sheena, additional, Lotery, Andrew J., additional, Majid, Mohammed, additional, McKibbin, Martin, additional, Menon, Geeta, additional, Andrews, Christopher, additional, Brittain, Christopher, additional, Osborne, Aaron, additional, and Yang, Yit, additional

Published
2013
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13. Age-related Macular Degeneration and Modification of Systemic Complement Factor H Production Through Liver Transplantation

Author

Khandhadia, Samir, primary, Hakobyan, Svetlana, additional, Heng, Ling Z., additional, Gibson, Jane, additional, Adams, David H., additional, Alexander, Graeme J., additional, Gibson, Jonathan M., additional, Martin, Keith R., additional, Menon, Geeta, additional, Nash, Kathryn, additional, Sivaprasad, Sobha, additional, Ennis, Sarah, additional, Cree, Angela J., additional, Morgan, B. Paul, additional, and Lotery, Andrew J., additional

Published
2013
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15. Clinical Course, Genetic Etiology, and Visual Outcome in Cone and Cone–Rod Dystrophy

Author

Thiadens, Alberta A.H.J., primary, Phan, T. My Lan, additional, Zekveld-Vroon, Renate C., additional, Leroy, Bart P., additional, van den Born, L. Ingeborgh, additional, Hoyng, Carel B., additional, Klaver, Caroline C.W., additional, Roosing, Susanne, additional, Pott, Jan-Willem R., additional, van Schooneveld, Mary J., additional, van Moll-Ramirez, Norka, additional, van Genderen, Maria M., additional, Boon, Camiel J.F., additional, den Hollander, Anneke I., additional, Bergen, Arthur A.B., additional, De Baere, Elfride, additional, Cremers, Frans P.M., additional, and Lotery, Andrew J., additional

Published
2012
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16. Clinical Implications of Old and New Genes for Open-Angle Glaucoma

Author

Ramdas, Wishal D., primary, van Koolwijk, Leonieke M.E., additional, Cree, Angela J., additional, Janssens, A. Cecile J.W., additional, Amin, Najaf, additional, de Jong, Paulus T.V.M., additional, Wolfs, Roger C.W., additional, Gibson, Jane, additional, Kirwan, James F., additional, Hofman, Albert, additional, Rivadeneira, Fernando, additional, Oostra, Ben A., additional, Uitterlinden, André G., additional, Ennis, Sarah, additional, Lotery, Andrew J., additional, Lemij, Hans G., additional, Klaver, Caroline C.W., additional, Vingerling, Johannes R., additional, Jansonius, Nomdo M., additional, and van Duijn, Cornelia M., additional

Published
2011
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17. Two-Year Results of the Phase 3 Randomized Controlled Study of Abicipar in Neovascular Age-Related Macular Degeneration

Author

Hansjürgen Agostini, Young Hee Yoon, Cedar, Rahul N. Khurana, Charles C. Wykoff, David R. Chow, Raj K. Maturi, Andrew Chang, Derek Y Kunimoto, Rubens Belfort, Eric H Souied, Masahito Ohji, Francesco Bandello, Andrew J. Lotery, Kimmie Kim, Yehia Hashad, Xiao-yan Li, Jenny Jiao, Grace Le, Werner Schmidt, Sequoia Study Groups, Khurana, Rahul N, Kunimoto, Derek, Yoon, Young Hee, Wykoff, Charles C, Chang, Andrew, Maturi, Raj K, Agostini, Hansjürgen, Souied, Eric, Chow, David R, Lotery, Andrew J, Ohji, Masahito, Bandello, Francesco, Belfort, Ruben, Li, Xiao-Yan, Jiao, Jenny, Le, Grace, Kim, Kimmie, Schmidt, Werner, and Hashad, Yehia

Subjects
Male, medicine.medical_specialty, Visual acuity, Time Factors, genetic structures, Recombinant Fusion Proteins, Visual Acuity, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, Ophthalmology, Medicine, Humans, Macula Lutea, 030304 developmental biology, Aged, 0303 health sciences, Dose-Response Relationship, Drug, business.industry, Incidence (epidemiology), Diabetic retinopathy, Macular degeneration, medicine.disease, Clinical trial, Choroidal neovascularization, Treatment Outcome, Intravitreal Injections, 030221 ophthalmology & optometry, Wet Macular Degeneration, Female, medicine.symptom, Ranibizumab, business, Tomography, Optical Coherence, medicine.drug, Follow-Up Studies
Abstract

To report the 2-year efficacy and safety of abicipar every 8 weeks and quarterly (after initial doses) compared with monthly ranibizumab in patients with treatment-naïve neovascular age-related macular degeneration (nAMD).Two multicenter, randomized, phase 3 clinical trials with identical protocols (CEDAR and SEQUOIA). Analyses used pooled trial data.The trials enrolled 1888 patients (1 eye/patient) with active choroidal neovascularization secondary to age-related macular degeneration and best-corrected visual acuity (BCVA) of 24 to 73 Early Treatment Diabetic Retinopathy Study letters.At enrollment, patients were assigned to study eye treatment with abicipar 2 mg every 8 weeks after initial doses at baseline and weeks 4 and 8 (abicipar Q8, n = 630), abicipar 2 mg every 12 weeks after initial doses at baseline and weeks 4 and 12 (abicipar Q12, n = 628), or ranibizumab 0.5 mg every 4 weeks (ranibizumab Q4, n = 630).Efficacy measures included stable vision (15-letter loss in BCVA from baseline) and change from baseline in BCVA and central retinal thickness (CRT). Safety measures included adverse events (AEs).For patients who completed the study, efficacy of abicipar after initial doses was maintained through week 104. At week 104, the proportion of patients with stable vision was 93.0% (396/426), 89.8% (379/422), and 94.4% (470/498); mean change in BCVA from baseline was +7.8 letters, +6.1 letters, and +8.5 letters, and mean change in CRT from baseline was -147 μm, -146 μm, and -142 μm in the abicipar Q8 (14 injections), abicipar Q12 (10 injections), and ranibizumab Q4 (25 injections) groups, respectively. The overall incidence of intraocular inflammation (IOI) AEs was 15.4%, 15.3%, and 0.3% from baseline through week 52 and 16.2%, 17.6%, and 1.3% from baseline through week 104 in the abicipar Q8, abicipar Q12, and ranibizumab Q4 groups, respectively.Two-year results show efficacy of abicipar Q8 and Q12 in nAMD. First onset of IOI events with abicipar was much reduced in the second year and comparable with ranibizumab (0.8% and 2.3% vs. 1.0%). The extended duration of effect of abicipar allows for quarterly dosing and reduced treatment burden.

Published
2020

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