1. Nodular sclerosing Hodgkin disease with primary manifestation in the orbit.
- Author
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Gross ND, Wilson DJ, Dailey RA, Beckstead JH, and Braziel RM
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers, Tumor metabolism, Biopsy, Bleomycin therapeutic use, Child, Dacarbazine therapeutic use, Doxorubicin therapeutic use, Hodgkin Disease metabolism, Hodgkin Disease therapy, Humans, Immunohistochemistry, Lymph Nodes metabolism, Male, Orbital Neoplasms metabolism, Orbital Neoplasms therapy, Radiotherapy, Adjuvant, Reed-Sternberg Cells pathology, Tomography, X-Ray Computed, Vinblastine therapeutic use, Hodgkin Disease diagnosis, Lymph Nodes pathology, Orbital Neoplasms diagnosis
- Abstract
Hodgkin disease with primary manifestation in the orbit is extremely rare, and even when suspected can be very difficult to diagnose. Its clinical and histological presentation can be nearly impossible to differentiate from that of a benign inflammatory process, and it is necessary to utilize immunohistochemical techniques to confirm the diagnosis. This article focuses on a case of nodular sclerosing Hodgkin disease with initial manifestation in the orbit. A comparison of the clinical, histological, and immunohistochemical presentations associated with both Hodgkin disease and benign inflammation is discussed. A brief review of the immunohistochemistry specific for Hodgkin disease is also provided.
- Published
- 1998
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