1. Determinants of Antiretroviral Treatment Success and Adherence in People With Human Immunodeficiency Virus Treated for Tuberculosis
- Author
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Nathalie, De Castro, Corine, Chazallon, Jean-Baptiste, N'takpe, Isabel, Timana, Rodrigo, Escada, Sandra, Wagner, Eugène, Messou, Serge, Eholie, Nilesh, Bhatt, Celso, Khosa, Didier, Laureillard, Giang, Do Chau, Valdilea G, Veloso, Constance, Delaugerre, Xavier, Anglaret, Jean-Michel, Molina, Beatriz, Grinsztejn, and Olivier, Marcy
- Subjects
Infectious Diseases ,Oncology - Abstract
Background In people with human immunodeficiency virus [HIV] presenting with advanced disease, rates of virologic success may be lower than expected. The Reflate TB2 trial did not show non-inferiority of raltegravir versus efavirenz in people with HIV (PWH) treated for tuberculosis. We aimed to identify factors associated with virologic success and higher adherence in the trial. Methods In this analysis, we included participants enrolled in the Reflate TB2 trial with adherence data available. The primary outcome was virologic success (HIV-1 ribonucleic acid [RNA] Results Four hundred forty-four participants were included in the present analysis. Over the 48-week follow-up period, 290 of 444 (65%) participants had a pill count adherence ratio ≥95%. At week 48, 288 of 444 (65%) participants were in virologic success. In the multivariate analysis, female sex (adjusted odds ratio [aOR], 1.77; 95% confidence interval [CI], 1.16–2.72; P = .0084), lower baseline HIV-1 RNA levels ( Conclusions In PWH with tuberculosis receiving raltegravir or efavirenz-based regimens, female sex, optimal adherence, and baseline HIV-1 RNA
- Published
- 2022