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Introduction. Acinetobacter baumannii is a pathogen and a major cause of nosocomial infections in the current healthcare system worldwide due to its high resistance to antibiotics, including those considered as a last resort, thus posing threat to severe clinical forms, as well as exhibiting significant economic and clinical impact. Material and methods. A descriptive longitudinal and cross-sectional epidemiological study was carried out based on the model of multidisciplinary care hospitals. Results. The generalized clinical forms of Acinetobacter nosocomial infections predominate in 56.30%, including: pulmonary sepsis – 25.59%, abdominal sepsis – 11.81%, septicemia – 9.45%, wound sepsis– 6.30%, biliary sepsis – 1.97%, and urosepsis – 1.18% of cases. Local infections were found in 16.93% of wound infections and in 14.57% of pneumonia cases. A. baumanii was present in the etiological structure of 98.18% of cases, exhibiting an increased resistance to antibiotics, particularly to monobactams – 100.0%, macrolides – 98.82%, penicillins – 98.08%, cephalosporins – 97.65%, penicillins with beta-lactamase inhibitors – 93.20%, fluoroquinolones – 87.16%, and amphenicols – 84.17% of cases. A. baumanii strains isolated from patients with nosocomial infections were found to be multidrug resistant to antibiotics in 93.08% of cases. Conclusions. Acinetobacter baumannii nosocomial infections represent a major public health issue that requires the implementation of strict surveillance and control strategies, including the rational use of antibiotics.

Introduction. Trophic ulcer continues to be a major clinical problem, currently having a significant socio-economic impact. The association of microbial infections, especially with antibiotic-resistant bacteria, is one of the most common complications of trophic ulcers. In this context, trophic ulcers associated with methicillin-resistant Staphylococcus (MRS) have a high epidemiological and clinical significance. Material and methods. The determination of risk factors, antimicrobial resistance, as well as the clinical and socio-economic impact of trophic ulcers caused by MRS strains was performed based on a retrospective case-control study. The research group included 52 observation sheets of patients with trophic ulcers caused by methicillin-resistant Staphylococcus (MRS), the control group - 39 sheets of patients with trophic ulcers caused by methicillin-sensitive Staphylococcus (MSS). Results. MRS strains isolated from trophic ulcers had high rates of antibiotic resistance compared to MSS strains. As a risk factors of trophic ulcer from which MRS strains have been isolated, people over the age of 50, repeated hospitalizations, microbial associations and exposure to intensive care are highlighted. Conclusions. Risk factors and local epidemiology knowledge in trophic ulcers with MRS is the key factor in implementing and complying with surveillance and control measures.