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Xue Leng,1 Geli Liu,1 Sen Wang,2 Jing Song,3 Wanfeng Zhang,3 Xianqin Zhang,1 Li Rong,1,4 Yongping Ma,1 Fangzhou Song1 1Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, People’s Republic of China; 2Laboratory Department, Affiliated Hospital of Jining Medical College, Shandong, 272029, People’s Republic of China; 3Department of Bioinformatics, The Basic Medical School of Chongqing Medical University, Chongqing 400016, People’s Republic of China; 4Department of Gastroenterology, Chongqing Public Health Medical Center, Chongqing, 400036, People’s Republic of ChinaCorrespondence: Fangzhou SongMolecular Medicine and Cancer Research Center, Chongqing Medical University, Yixueyuan Road, Yuzhong District, Chongqing 400016, People’s Republic of ChinaTel +86 23 68485958Email fzsongcq@163.comPurpose: Gastric cancer (GC) is the fifth most common tumor in the world, and most patients with GC have a poor prognosis. This study aimed to explore the biological influence and mechanism of LINC01272 in GC.Materials and Methods: Using bioinformatic analyses, we investigated the expression of LINC01272 in TCGA database and predicted the biological functions and mechanism of LINC01272 in GC. Then, we detected the expression of LINC01272 in GC cell lines, GC tissues, and corresponding normal tissues using real-time polymerase chain reaction (RT-PCR). Finally, we explored the migration and invasion ability of LINC01272 by wound-healing and Transwell assays and examined the expression of epithelial-mesenchymal transition (EMT)-related proteins through Western blotting.Results: We found that LINC01272 was upregulated in GC and was associated with GC staging and lymph node metastasis. The results ofwound-healing and Transwell assays revealed that the LINC01272 was closely related to GC cell migration and invasion. LINC01272 knockdown inhibited the migration and invasion ability of GC cells by reducing the expression of EMT-related proteins. Overexpression of LINC01272 had the opposite effect.Conclusion: Together, our results showed that LINC01272 promoted GC metastasis ability by regulating the expression of EMT-related proteins and could serve as a potential diagnostic biomarker for GC.Keywords: gastric cancer, long non-coding RNA, migration, invasion, LINC01272

Jia Y, Li H, Liu G, Song F. OncoTargets Ther. 2018;11:6925– 6935.On page 6933, Figure 4B artwork is incorrect. Figure 4Bartwork was mistakenly interchanged by the Editorial staffduring the publication process.Read the original article

Yongqin Jia,1,2 Haiyu Li,1,3 Geli Liu,1,2 Fangzhou Song1,2 1Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China; 2Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing 400016, China; 3Department of Infectious Disease, Chongqing Infectious Disease Medical Center, Chongqing 400030, China Introduction: Cervical cancer, one of the most common malignant gynecological tumors, is a significant burden on the health of females worldwide. The purpose of this study was to investigate genes associated with lymph node metastasis in cervical cancer. Methods: We report on the lymph node metastasis-associated gene, small cell adhesion glycoprotein (SMAGP), as a key regulator of cervical cancer development and progression. SMAGP expression levels were investigated in 70 cervical squamous cell carcinoma samples and 10 normal cervical squamous epithelium samples. Results: Immunohistochemistry analysis revealed that SMAGP protein levels were significantly elevated in cervical cancer tissue compared with normal cervical squamous epithelium. Silencing of SMAGP induced cell cycle arrest, inhibited the cell proliferation and colony formation ability of cervical cancer cells in vitro and suppressed their tumorigenic potential in nude mice. In addition, SMAGP knockdown reduced expression of epithelial mesenchymal transition-related proteins, including vimentin, β-cadherin, MMP2, and Twist. Conclusion: Together, our findings demonstrate that SMAGP plays a critical role in cell proliferation and tumorigenesis and could be a new therapeutic target in cervical cancer. Keywords: cervical cancer, small cell adhesion glycoprotein, bioinformatics, cell cycle