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Your search keyword '"Wang, Guobin"' showing total 11 results
Start Over Author "Wang, Guobin" Journal oncotarget
11 results on '"Wang, Guobin"'

11. miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPβ.

Author

Zhang XF, Li KK, Gao L, Li SZ, Chen K, Zhang JB, Wang D, Tu RF, Zhang JX, Tao KX, Wang G, and Zhang XD

Subjects
Animals, Apoptosis genetics, CCAAT-Enhancer-Binding Protein-beta biosynthesis, CCAAT-Enhancer-Binding Protein-beta genetics, Carcinogenesis genetics, Cell Line, Tumor, Cell Proliferation physiology, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology, HCT116 Cells, HEK293 Cells, HT29 Cells, Heterografts, Humans, Mice, Mice, Inbred BALB C, Mice, Nude, MicroRNAs antagonists & inhibitors, MicroRNAs biosynthesis, MicroRNAs metabolism, CCAAT-Enhancer-Binding Protein-beta metabolism, Colorectal Neoplasms metabolism, MicroRNAs genetics
Abstract

MicroRNA-191 (miR-191), a small non-coding RNA, is involved in disease development and cancer diagnosis and prognosis. However, how miR-191 functions in colorectal cancer remains largely unclear. In this study, we show that miR-191 is highly expressed in colon tumor tissues, and that inhibition of miR-191 leads to decreased cell growth, proliferation and tumorigenicity in a xenograft model. Overexpression of miR-191 in colorectal cancer cell lines alters cell cycle progression and cell resistance to 5-Fu induced cell apoptosis. Mechanistic studies demonstrated that miR-191 directly binds to the 3'UTR of the C/EBPβ mRNA and mediates a decrease in the mRNA and protein expression of C/EBPβ. We further showed that C/EBPβ induces growth arrest in a colorectal cancer cell line and that its expression is negatively correlated with the miR-191 level in patient samples. Our findings suggest that miR-191 may be a potential gene therapy target for the treatment of colorectal cancer.

Published
2015
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