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Your search keyword '"Manyam, Ganiraju C"' showing total 7 results
Start Over Author "Manyam, Ganiraju C" Journal oncotarget
7 results on '"Manyam, Ganiraju C"'

1. Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma

Author

Pham, Lan V., primary, Bryant, Jerry L., additional, Mendez, Richard, additional, Chen, Juan, additional, Tamayo, Archito T., additional, Xu-Monette, Zijun Y., additional, Young, Ken H., additional, Manyam, Ganiraju C., additional, Yang, David, additional, Medeiros, L. Jeffrey, additional, and Ford, Richard J., additional

Published
2016
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2. MET amplification in metastatic colorectal cancer: an acquired response to EGFR inhibition, not a de novo phenomenon

Author

Raghav, Kanwal, primary, Morris, Van, additional, Tang, Chad, additional, Morelli, Pia, additional, Amin, Hesham M., additional, Chen, Ken, additional, Manyam, Ganiraju C., additional, Broom, Bradley, additional, Overman, Michael J., additional, Shaw, Kenna, additional, Meric-Bernstam, Funda, additional, Maru, Dipen, additional, Menter, David, additional, Ellis, Lee M., additional, Eng, Cathy, additional, Hong, David, additional, and Kopetz, Scott, additional

Published
2016
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3. Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma

Author

Ye, Qing, primary, Xu-Monette, Zijun Y., additional, Tzankov, Alexandar, additional, Deng, Lijuan, additional, Wang, Xiaoxiao, additional, Manyam, Ganiraju C., additional, Visco, Carlo, additional, Montes-Moreno, Santiago, additional, Zhang, Li, additional, Dybkær, Karen, additional, Chiu, April, additional, Orazi, Attilio, additional, Zu, Youli, additional, Bhagat, Govind, additional, Richards, Kristy L., additional, Hsi, Eric D., additional, Choi, William W.L., additional, van Krieken, J. Han, additional, Huh, Jooryung, additional, Ponzoni, Maurilio, additional, Ferreri, Andrés J.M., additional, Parsons, Ben M., additional, Møller, Michael B., additional, Piris, Miguel A., additional, Winter, Jane N., additional, Medeiros, L. Jeffrey, additional, Hu, Shimin, additional, and Young, Ken H., additional

Published
2015
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4. Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma

Author

Li, Ling, primary, Xu-Monette, Zijun Y., additional, Ok, Chi Young, additional, Tzankov, Alexandar, additional, Manyam, Ganiraju C., additional, Sun, Ruifang, additional, Visco, Carlo, additional, Zhang, Mingzhi, additional, Montes-Moreno, Santiago, additional, Dybkaer, Karen, additional, Chiu, April, additional, Orazi, Attilio, additional, Zu, Youli, additional, Bhagat, Govind, additional, Richards, Kristy L., additional, Hsi, Eric D., additional, Choi, William W.L., additional, van Krieken, J. Han, additional, Huh, Jooryung, additional, Ponzoni, Maurilio, additional, Ferreri, Andrés J.M., additional, Møller, Michael B., additional, Wang, Jinfen, additional, Parsons, Ben M., additional, Winter, Jane N., additional, Piris, Miguel A., additional, Pham, Lan V., additional, Medeiros, L. Jeffrey, additional, and Young, Ken H., additional

Published
2015
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5. Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma-is it necessary?

Author

Ok, Chi Young, primary, Ye, Qing, additional, Li, Ling, additional, Manyam, Ganiraju C., additional, Deng, Lijuan, additional, Goswami, Rashmi R., additional, Wang, Xiaoxiao, additional, Montes-Moreno, Santiago, additional, Visco, Carlo, additional, Tzankov, Alexandar, additional, Dybkaer, Karen, additional, Zhang, Li, additional, Abramson, Jeremy, additional, Sohani, Aliyah R., additional, Chiu, April, additional, Orazi, Attilio, additional, Zu, Youli, additional, Bhagat, Govind, additional, Richards, Kristy L., additional, Hsi, Eric D., additional, Choi, William W.L., additional, van Krieken, J. Han, additional, Huh, Jooryung, additional, Ponzoni, Maurilio, additional, Ferreri, Andrés J.M., additional, Zhang, Shanxiang, additional, Parsons, Ben M., additional, Xu, Mina, additional, Møller, Michael B., additional, Winter, Jane N., additional, Piris, Miguel A., additional, Xu-Monette, Zijun Y., additional, Medeiros, L. Jeffrey, additional, and Young, Ken H., additional

Published
2015
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6. Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma

Author

Chen, Jiayu, primary, Xu-Monette, Zijun Y., additional, Deng, Lijuan, additional, Shen, Qi, additional, Manyam, Ganiraju C., additional, Martinez-Lopez, Azahara, additional, Zhang, Li, additional, Montes-Moreno, Santiago, additional, Visco, Carlo, additional, Tzankov, Alexandar, additional, Yin, Lihui, additional, Dybkaer, Karen, additional, Chiu, April, additional, Orazi, Attilio, additional, Zu, Youli, additional, Bhagat, Govind, additional, Richards, Kristy L., additional, Hsi, Eric D., additional, Choi, William W.L., additional, van Krieken, J. Han, additional, Huh, Jooryung, additional, Ponzoni, Maurilio, additional, Ferreri, Andrés J.M., additional, Zhao, Xiaoying, additional, Møller, Michael B., additional, Farnen, John P., additional, Winter, Jane N., additional, Piris, Miguel A., additional, Pham, Lan, additional, and Young, Ken H., additional

Published
2015
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7. Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma.

Author

Ye Q, Xu-Monette ZY, Tzankov A, Deng L, Wang X, Manyam GC, Visco C, Montes-Moreno S, Zhang L, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Parsons BM, Møller MB, Piris MA, Winter JN, Medeiros LJ, Hu S, and Young KH

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cyclophosphamide therapeutic use, Disease-Free Survival, Doxorubicin therapeutic use, Female, Humans, Lymphoma, Large B-Cell, Diffuse drug therapy, Male, Middle Aged, Prednisone therapeutic use, Rituximab, Translocation, Genetic, Vincristine therapeutic use, Young Adult, Lymphoma, Large B-Cell, Diffuse genetics, Lymphoma, Large B-Cell, Diffuse mortality, Proto-Oncogene Proteins c-bcl-2 genetics, Proto-Oncogene Proteins c-bcl-6 genetics, Proto-Oncogene Proteins c-myc genetics
Abstract

Double-hit B-cell lymphoma is a common designation for a group of tumors characterized by concurrent translocations of MYC and BCL2, BCL6, or other genes. The prognosis of concurrent MYC and BCL6 translocations is not well known. In this study, we assessed rearrangements and expression of MYC, BCL2 and BCL6 in 898 patients with de novo diffuse large B-cell lymphoma treated with standard chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab). Neither BCL6 translocation alone (more frequent in activated B-cell like diffuse large B-cell lymphoma) nor in combination with MYC translocation (observed in 2.0% of diffuse large B-cell lymphoma) predicted poorer survival in diffuse large B-cell lymphoma patients. Diffuse large B-cell lymphoma patients with MYC/BCL6 co-expression did have significantly poorer survival, however, MYC/BCL6 co-expression had no effect on prognosis in the absence of MYC/BCL2 co-expression, and had no additive impact in MYC+/BCL2+ cases. The isolated MYC+/BCL6+/BCL2- subset, more frequent in germinal center B-cell like diffuse large B-cell lymphoma, had significantly better survival compared with the isolated MYC+/BCL2+/BCL6- subset (more frequent in activated B-cell like diffuse large B-cell lymphoma). In summary, diffuse large B-cell lymphoma patients with either MYC/BCL6 rearrangements or MYC/BCL6 co-expression did not always have poorer prognosis; MYC expression levels should be evaluated simultaneously; and double-hit B-cell lymphoma needs to be refined based on the specific genetic abnormalities present in these tumors.

Published
2016
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