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Your search keyword '"He, Jian‐Rong"' showing total 5 results
Start Over Author "He, Jian‐Rong" Journal oncotarget
5 results on '"He, Jian‐Rong"'

2. Distribution patterns of 21-gene recurrence score in 980 Chinese estrogen receptor-positive, HER2-negative early breast cancer patients

Author

Wu, Jiayi, primary, Fang, Yan, additional, Lin, Lin, additional, Fei, Xiaochun, additional, Gao, Weiqi, additional, Zhu, Siji, additional, Zong, Yu, additional, Chen, Xiaosong, additional, Huang, Ou, additional, He, Jian-Rong, additional, Zhu, Li, additional, Chen, Weiguo, additional, Li, Yafen, additional, and Shen, Kunwei, additional

Published
2017
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4. MiR-630 suppresses breast cancer progression by targeting metadherin

Author

Zhou, Ci-Xiang, primary, Wang, Chen-Long, additional, Yu, An-Lu, additional, Wang, Qiu-Yu, additional, Zhan, Meng-Na, additional, Tang, Jun, additional, Gong, Xiu-Feng, additional, Yin, Qian-Qian, additional, He, Ming, additional, He, Jian-Rong, additional, Chen, Guo-Qiang, additional, and Zhao, Qian, additional

Published
2015
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5. MiR-630 suppresses breast cancer progression by targeting metadherin.

Author

Zhou CX, Wang CL, Yu AL, Wang QY, Zhan MN, Tang J, Gong XF, Yin QQ, He M, He JR, Chen GQ, and Zhao Q

Subjects
Adult, Aged, Aged, 80 and over, Animals, Blotting, Western, Breast Neoplasms metabolism, Breast Neoplasms pathology, Cell Adhesion Molecules metabolism, Cell Line, Cell Line, Tumor, Cell Movement genetics, Disease Progression, Down-Regulation, Female, Humans, Membrane Proteins, Mice, Inbred NOD, Middle Aged, Neoplasm Invasiveness, Neoplasm Metastasis, RNA-Binding Proteins, Reverse Transcriptase Polymerase Chain Reaction, Transplantation, Heterologous, Breast Neoplasms genetics, Cell Adhesion Molecules genetics, Gene Expression Regulation, Neoplastic, MicroRNAs genetics
Abstract

MicroRNAs have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. The miR-630 was reported to be deregulated and involved in tumor progression of several human malignancies. However, its expression regulation shows diversity in different kinds of cancers and its potential roles remain greatly elusive. Herein, we demonstrate that miR-630 is significantly suppressed in human breast cancer specimens, as well as in various breast cancer cell lines. In aggressive MDA-MB-231-luc and BT549 breast cancer cells, ectopic expression of miR-630 strongly inhibits cell motility and invasive capacity in vitro. Moreover, lentivirus delivered miR-630 bestows MDA-MB-231-luc cells with the ability to suppress cell colony formation in vitro and pulmonary metastasis in vivo. Further studies identify metadherin (MTDH) as a direct target gene of miR-630. Functional studies shows that MTDH contributes to miR-630-endowed effects including cell migration and invasion as well as colony formation in vitro. Taken together, these findings highlight an important role for miR-630 in the regulation of metastatic potential of breast cancer and suggest a potential application of miR-630 in breast cancer treatment.

Published
2016
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