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Your search keyword '"Nishimura, Yoji"' showing total 4 results
Start Over Author "Nishimura, Yoji" Journal oncology reports
4 results on '"Nishimura, Yoji"'

4. High concordance rate of KRAS/BRAF mutations and MSI-H between primary colorectal cancer and corresponding metastases.

Author

Fujiyoshi K, Yamamoto G, Takahashi A, Arai Y, Yamada M, Kakuta M, Yamaguchi K, Akagi Y, Nishimura Y, Sakamoto H, and Akagi K

Subjects
Biomarkers, Tumor genetics, Case-Control Studies, Colorectal Neoplasms pathology, Follow-Up Studies, Humans, Liver Neoplasms genetics, Liver Neoplasms secondary, Lung Neoplasms genetics, Lung Neoplasms secondary, Lymphatic Metastasis, Neoplasm Recurrence, Local genetics, Neoplasm Recurrence, Local secondary, Neoplasm Staging, Neoplasms, Multiple Primary secondary, Neoplasms, Second Primary secondary, Peritoneal Neoplasms genetics, Peritoneal Neoplasms secondary, Prognosis, Colorectal Neoplasms genetics, Microsatellite Instability, Mutation genetics, Neoplasms, Multiple Primary genetics, Neoplasms, Second Primary genetics, Proto-Oncogene Proteins B-raf genetics, Proto-Oncogene Proteins p21(ras) genetics
Abstract

Genetic testing is needed for the treatment of colorectal cancer (CRC), especially molecular-targeted therapy. The effects of anti-EGFR therapy and prognosis are affected by the presence of KRAS mutations. However, whether primary CRC or metastatic tissues are appropriate in the analysis is still unclear. In the present study, we assessed the concordance of KRAS/BRAF mutation status and microsatellite instability (MSI) in primary CRC and corresponding metastases. This study enrolled 457 patients with surgically resected primary and corresponding metastatic CRC (499 synchronous metastases and 57 metachronous metastases) and seven local recurrences, and KRAS/BRAF mutation and MSI status were analysed for these tumours. The concordance rates of KRAS mutation, BRAF mutation, wild-type, MSI-H and MSS between primary CRC and corresponding metastases were 93.9% (214/228), 100% (30/30), 99.3% (304/306), 87.5% (21/24) and 100% (137/137), respectively. These high concordance rates were not different between synchronous and metachronous metastases. In conclusion, a high concordance of KRAS/BRAF mutation status and MSI status was observed between primary CRC and corresponding metastases in this study. Either primary CRC or metastatic tissues can be used for testing KRAS/BRAF mutation status and MSI status.

Published
2017
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