1. Sequential docetaxel and vinorelbine for patients with advanced breast cancer previously treated with anthracyclines: a phase II study
- Author
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Brugnatelli S, Riccardi A, Danova M, Pugliese P, Carmine Tinelli, Luchena G, Bernardo A, Giardina G, Fava S, Montanari G, Pedrotti C, and Am, Poli
- Subjects
Adult ,Paclitaxel ,Breast Neoplasms ,Vinorelbine ,Docetaxel ,Middle Aged ,Vinblastine ,Antineoplastic Agents, Phytogenic ,Disease-Free Survival ,Drug Administration Schedule ,Survival Rate ,Treatment Outcome ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Anthracyclines ,Female ,Taxoids ,Neoplasm Metastasis ,Aged - Abstract
With respect to their association, sequential non-cross-resistant cytostatics could be better tolerated and allow a similar antitumor effect. From January, 1998 to July, 1999, 42 consecutive patients with metastatic breast cancer (MBC) previously treated with anthracyclines as adjuvant- or first-line therapy entered a phase II multicenter study where docetaxel (TXT, 100 mg/m2/3 weeks/4 times) was followed by vinorelbine (VNR, 25 mg/m2/10 days/8 times). Median follow-up is 21 months and 22/42 patients have died. Four patients did not complete therapy due to early death, grade 3-4 gastrointestinal mucosytis (2 patients) and grade 3 neurotoxicity during TXT therapy. Overall response rate was 57%, and 5% of patients had stable disease. There were 38% of therapy failures due to non-evaluability (10%) or progressive disease (28%). Median time to progression and survival are 10.1 and 17.1 months. Sequential TXT-VNB is a suitable strategy for MBC patients previously treated with anthracyclines. It avoids haematologic toxicity and allows a good antitumor effect. Careful monitoring of intestinal mucosytis is required.
- Published
- 2001