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Start Over Author "Richeng Quan" Journal oncology letters
3 results on '"Richeng Quan"'

1. Cytogenetic characteristics of 665 patients with myelodysplastic syndrome in China: A single-center report

Author

Xueying Wang, Teng Fan, Chi Liu, Yumeng Li, Hongzhi Wang, Richeng Quan, Liu Li, Xiupeng Yang, Yong-Gang Xu, Shan-shan Zhang, Zhuo Chen, Xiao-Mei Hu, Weiyi Liu, Haiyan Xiao, Xiaoqing Guo, Yan Lv, Xudong Tang, Mingjing Wang, and Rou Ma

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, Trisomy 8, Single Center, Gastroenterology, chromosome karyotype, cytogenetics, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, WHO classification, prognostic scoring system, business.industry, Incidence (epidemiology), Cytogenetics, Cancer, Karyotype, Articles, medicine.disease, myelodysplastic syndrome, 030104 developmental biology, Oncology, International Prognostic Scoring System, Dysplasia, 030220 oncology & carcinogenesis, business
Abstract

The karyotype is highly important for diagnosis and prognosis in myelodysplastic syndrome (MDS). The objective of the present study was to investigate the cytogenetic characteristics of patients with MDS in China. The karyotypes of 665 Chinese patients with MDS were analyzed, and it was identified that 298 cases (298/665, 44.8%) had abnormal karyotypes. Among the 298 patients with abnormal karyotypes, the 75 patients with trisomy 8 (+8) constituted the most common subset (75/298, 25.2%). The incidence of abnormal karyotypes was significantly higher in patients who were ≥51 years old compared with those

Published
2020

2. Genetic alterations in 47 patients with a novel myelodysplastic syndrome diagnosis at a single center

Author

Pan Zhao, Jiayue Qin, Haiyan Xiao, Yan Lv, Richeng Quan, Xiaoqing Guo, Hongzhi Wang, Juan Wang, Liu Li, Weiyi Liu, Chi Liu, Qianze Zhu, and Xiao-Mei Hu

Subjects
Cancer Research, Mutation, genetic alterations, Janus kinase 2, biology, Tet methylcytosine dioxygenase 2, Cancer, Articles, medicine.disease_cause, medicine.disease, Molecular biology, Molecular medicine, DNA sequencing, myelodysplastic syndrome, U2 small nuclear RNA auxiliary factor 1, Oncology, medicine, biology.protein, next-generation sequencing, Gene, clinicopathological features
Abstract

At least one mutation is present in 70–80% of patients with myelodysplastic syndrome (MDS). Genetic alterations and other molecular biological markers have been included in the diagnostic and treatment guidelines for MDS. The aim of the present study was to analyze the association between genetic alterations and clinicopathological features among 47 Chinese patients with a novel diagnosis of MDS using a next-generation sequencing approach. The results indicated that from the 47 patients, 66.0% had genetic alterations. Furthermore, seven genes, U2 small nuclear RNA auxiliary factor 1 (23.4%), splicing factor 3b subunit (12.8%), ASXL transcriptional regulator 1 (10.6%), tet methylcytosine dioxygenase 2 (8.5%), BCL6 corepressor (8.5%), TP53 (8.5%) and DNA methyltransferase 3α (6.4%), indicated a higher prevalence of alterations in >5% of patients. Among the 16 (51.6%) patients with ≥2 mutations, 12 (75%) had mutations in different genetic functional groups. Variant allele frequencies in signaling pathways were generally low, suggesting that mutations in the corresponding genes were acquired relatively late during the evolution of the leukemic clones. The mutation prevalence rates of Janus kinase 2 and SH2B adaptor protein 3 were significantly higher in the MDS unclassified group and in the very high-risk groups with a karyotype as a prognostic indicator, respectively (both P

Published
2019
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3. Cytogenetic characteristics of 665 patients with myelodysplastic syndrome in China: A single-center report.

Author

XUEYING WANG, WEIYI LIU, MINGJING WANG, TENG FAN, YUMENG LI, XIAOQING GUO, XIUPENG YANG, HONGZHI WANG, HAIYAN XIAO, SHANSHAN ZHANG, RICHENG QUAN, CHI LIU, XUDONG TANG, YAN LV, ZHUO CHEN, LIU LI, YONGGANG XU, ROU MA, and XIAOMEI HU

Subjects
MYELODYSPLASTIC syndromes, OLDER patients, KARYOTYPES, CHINESE people, TRISOMY
Abstract

The karyotype is highly important for diagnosis and prognosis in myelodysplastic syndrome (MDS). The objective of the present study was to investigate the cytogenetic characteristics of patients with MDS in China. The karyotypes of 665 Chinese patients with MDS were analyzed, and it was identified that 298 cases (298/665, 44.8%) had abnormal karyotypes. Among the 298 patients with abnormal karyotypes, the 75 patients with trisomy 8 (+8) constituted the most common subset (75/298, 25.2%). The incidence of abnormal karyotypes was significantly higher in patients who were ≥51 years old compared with those <51 years old, (54.8 vs. 34.7%, respectively; P<0.05). Based on World Health Organization (WHO) classification-based Prognostic Scoring System (WPSS) criteria, the incidence of poor-prognosis karyotypes was significantly higher (17.4 vs. 5.4%; P<0.05) in the older patient group, and based on the Revised International Prognostic Scoring System (IPSS-R) criteria, the incidence of poor-/very poor-prognosis karyotypes was also significantly higher (17.4 vs. 6.6%; P<0.05) in patients ≥51 years old compared with younger ones. Based on the WHO classification of MDS subtypes, the incidence of abnormal karyotypes in patients with high percentages of bone marrow (BM) blasts [excess blasts (EB)-I + EB-II, ≥5% blasts] was significantly higher than that in patients with low percentages of BM blasts (those with single lineage dysplasia + multilineage dysplasia, <5% blasts) (62.5 vs. 36.0%; P<0.05). The incidence of poor-prognosis karyotypes based on WPSS criteria was significantly higher in patients with high percentages of BM blasts than those with low percentages (22.0 vs. 6.9%, respectively; P<0.05), and the incidence of poor-/very poor-prognosis karyotypes based on IPSS-R criteria was also significantly higher (23.0 vs. 7.4%, respectively; P<0.05). These results demonstrate that +8 is the most common abnormal karyotype in Chinese patients with MDS. Age and the percentage of BM blasts are associated with the incidence of both abnormal karyotypes and karyotypes with poor prognosis. The results of cytogenetic abnormalities in this study will supplement the data on patients of MDS in China. [ABSTRACT FROM AUTHOR]

Published
2021
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