1. Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma
- Author
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Wei Qu, Hong‑Xiang Gu, Fang Yang, Ling Wang, Gong‑Li Yang, Hai‑Yan Zhang, Xin‑Ying Wang, Jin‑Dong Fu, and Ya-Li Zhang
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,biology ,Oncogene ,business.industry ,Articles ,Cell cycle ,Molecular medicine ,digestive system diseases ,Vascular endothelial growth factor ,chemistry.chemical_compound ,Oncology ,chemistry ,biology.protein ,Cancer research ,Biomarker (medicine) ,PTEN ,Tensin ,Medicine ,business ,neoplasms ,Pathological - Abstract
There are limitations to the use of single biomarker levels, for example phosphate and tensin homology (PTEN) or vascular endothelial growth factor (VEGF), in the diagnosis of esophageal squamous cell carcinoma (ESCC). The present study therefore aimed to evaluate the clinical implications of combined detection of multiple biomarkers. The associations between PTEN and VEGF expression status, microvessel density (MVD), and the pathological characteristics of 50 patients with ESCC were determined using χ2, analysis of variance, and t-tests. The results indicated that the PTEN-positive rate was negatively correlated with ESCC histological grade (P
- Published
- 2015
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