1. Expression of p53 and Glutathione S-Transferase-π Relates to Clinical Drug Resistance in Non-Small Cell Lung Cancer
- Author
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Chikako Kiyohara, Yoichi Nakanishi, Koichi Takayama, Nobuyuki Hara, Sin Ichi Osaki, Koichi Takano, Xin Hai Pei, Fen Bai, Masayuki Kawasaki, and Koji Inoue
- Subjects
Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Lung Neoplasms ,medicine.medical_treatment ,Drug resistance ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Carcinoma ,Humans ,Lung cancer ,Aged ,Glutathione Transferase ,Cisplatin ,Chemotherapy ,business.industry ,Respiratory disease ,General Medicine ,Middle Aged ,medicine.disease ,Drug Resistance, Multiple ,Gene Expression Regulation, Neoplastic ,Logistic Models ,Drug Resistance, Neoplasm ,Immunohistochemistry ,Female ,Tumor Suppressor Protein p53 ,business ,Immunostaining ,medicine.drug - Abstract
To determine the predictive value of the expression of p53 and glutathione S-transferase-π (GST-π) with respect to chemotherapy response, immunostaining was performed on transbronchial biopsy specimens from previously untreated patients with non-small cell lung cancer. Of the 54 patients, 34 patients (63%) and 37 patients (69%) were positive for p53 and GST-π, respectively. The response rates in the p53-positive and p53-negative group were 15 and 45%, and those in GST-π-positive and GST-π-negative groups were 16 and 47%, respectively. A multiple logistic regression analysis revealed that positive immunostaining for GST-π was a significant risk factor for clinical chemotherapy resistance. The combination of these two markers was the most important independent factor in predicting a response to chemotherapy in multiple logistic regression analysis. Immunohistochemical expression of p53 and GST-π was independently related to clinical chemoresistance in patients with non-small cell lung cancer. Combined use of these two biomarkers may be a useful predictor of clinical chemoresistance.
- Published
- 1999
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