1. Influence of Platinum-Induced Renal Toxicity on Bleomycin-Induced Pulmonary Toxicity in Patients with Disseminated Testicular Carcinoma
- Author
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Hs Koops, Dirk Sleijfer, Pwc Vanbarneveld, R Peset, Hj Sluiter, Tw Vandermark, Ajm Donker, Nanno Mulder, and Sytze Meijer
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Pathology ,endocrine system diseases ,Pulmonary toxicity ,Vital Capacity ,Urology ,Renal function ,Kidney ,Kidney Function Tests ,Vinblastine ,urologic and male genital diseases ,Bleomycin ,Pulmonary function testing ,chemistry.chemical_compound ,Testicular Neoplasms ,DLCO ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Medicine ,Drug Interactions ,Lung ,urogenital system ,business.industry ,General Medicine ,Effective renal plasma flow ,Middle Aged ,Respiratory Function Tests ,Oncology ,chemistry ,Regional Blood Flow ,Toxicity ,Testicular carcinoma ,Cisplatin ,business ,Glomerular Filtration Rate - Abstract
Pulmonary function tests, including T1CO, and renal function tests were performed and GFR and ERPF measured in 18 patients with disseminated testicular non-seminoma before and after remission induction according to the Einhorn regimen. We found a significant positive correlation between delta GFR and delta T1CO (p less than 0.05). No significance could be demonstrated between delta ERPF and delta T1CO. It is concluded that caution should be exercised in administrating bleomycin to patients with severely impaired renal function.
- Published
- 1984
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