Search

Your search keyword '"Lorenzo Fornaro"' showing total 4 results
Start Over Author "Lorenzo Fornaro" Journal oncology
4 results on '"Lorenzo Fornaro"'

1. Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients

Author

Elisa Paolicchi, Vincenzo Ricci, Fotios Loupakis, Caterina Vivaldi, Lorenzo Fornaro, Monica Ronzoni, Francesco Graziano, Romano Danesi, Gianluca Masi, Francesco Crea, Alfredo Falcone, and Veronica De Gregorio

Subjects
Oncology, Cancer Research, medicine.medical_specialty, biology, Colorectal cancer, business.industry, Topoisomerase, Single-nucleotide polymorphism, General Medicine, medicine.disease, digestive system diseases, Irinotecan, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, FOLFIRI, Cancer research, biology.protein, 030211 gastroenterology & hepatology, business, medicine.drug
Abstract

Objective:Topoisomerase 1 (topo-1) is an important target for the treatment of metastatic colorectal cancer (CRC). The aim of the present study was to evaluate the correlation between topo-1 single-nucleotide polymorphisms (SNPs) and clinical outcome in metastatic CRC (mCRC) patients. Methods: With the use of specific software (PROMO 3.0), we performed an in silico analysis of topo-1 promoter SNPs; the rs6072249 and rs34282819 SNPs were included in the study. DNA was extracted from 105 mCRC patients treated with FOLFIRI ± bevacizumab in the first line. SNP genotyping was performed by real-time PCR. Genotypes were correlated with clinical parameters (objective response rate, progression-free survival, and overall survival). Results: No single genotype was significantly associated with clinical variables. The G allelic variant of rs6072249 topo-1 SNP is responsible for GC factor and X-box-binding protein transcription factor binding. The same allelic variant showed a nonsignificant trend toward a shorter progression-free survival (GG, 7.5 months; other genotypes, 9.3 months; HR 1.823, 95% CI 0.8904-3.734; p = 0.1). Conclusion: Further analyses are needed to confirm that the topo-1 SNP rs6072249 and transcription factor interaction could be a part of tools to predict clinical outcome in mCRC patients treated with irinotecan-based regimens.

Published
2016

2. Estimating Survival Probabilities of Advanced Gastric Cancer Patients in the Second-Line Setting: The Gastric Life Nomogram

Author

Jeeyun Lee, Se Hoon Park, Michele Prisciandaro, Ferdinando De Vita, Lorenzo Antonuzzo, Giovanni Fucà, Nicola Silvestris, Francesco Leone, Samantha Di Donato, Gianluca Tomasello, Rosalba Miceli, Daniele Santini, Federica Morano, Giuseppe Aprile, Lorenza Rimassa, Antonio Avallone, Lorenzo Fornaro, Luca Faloppi, Maria Di Bartolomeo, Filippo de Braud, Monica Niger, Filippo Pietrantonio, Roberto Bordonaro, Valentina Fanotto, Francesco Barretta, S. Noventa, Francesca Bergamo, Pietrantonio, Filippo, Barretta, Francesco, Fanotto, Valentina, Park, Se Hoon, Morano, Federica, Fucà, Giovanni, Niger, Monica, Prisciandaro, Michele, Silvestris, Nicola, Bergamo, Francesca, Fornaro, Lorenzo, Bordonaro, Roberto, Rimassa, Lorenza, Santini, Daniele, Tomasello, Gianluca, Antonuzzo, Lorenzo, Noventa, Silvia, Avallone, Antonio, Leone, Francesco, Faloppi, Luca, Di Donato, Samantha, de Braud, Filippo, Lee, Jeeyun, De Vita, Ferdinando, Di Bartolomeo, Maria, Miceli, Rosalba, and Aprile, Giuseppe

Subjects
0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, Prognostic variable, Advanced gastric cancer, Prognosi, ECOG Performance Status, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasm, Stomach Neoplasms, Internal medicine, Republic of Korea, medicine, Humans, Aged, Proportional Hazards Models, Proportional hazards model, business.industry, Stomach, Cancer, General Medicine, Nomogram, Middle Aged, medicine.disease, Clinical trial, Nomograms, 030104 developmental biology, Italy, 030220 oncology & carcinogenesis, Proportional Hazards Model, Female, Cohort Studie, business, Cohort study, Human
Abstract

Objective: We built and externally validated a nomogram for predicting the overall survival (OS) probability of advanced gastric cancer patients receiving second-line treatment. Methods: The nomogram was developed on a set of 320 Italian patients and validated on two independent sets (295 Italian and 172 Korean patients). Putative prognostic variables were selected using a random forest model and included in the multivariable Cox model. The nomogram’s performance was evaluated by calibration plot and C index. Results: ECOG performance status, neutrophils to lymphocytes ratio, and peritoneal involvement were selected and included into the multivariable model. The C index was 0.72 (95% CI 0.68–0.75) in the development set, 0.69 (95% CI 0.65–0.73) in the Italian validation set, but only 0.57 (95% CI 0.52–0.62) in the Korean set. While Italian calibrations were quite good, the Korean one was poor. Regarding 6-month OS predictions, calibration was best in both Caucasian cohorts and worst the in Asian one. Conclusions: Our nomogram may be a useful tool to predict 3- or 6-month OS in Caucasian gastric cancer patients eligible for second-line therapy. Based on three easy-to-collect variables, the Gastric Life nomogram may help clinicians improve patient selection for second-line treatments and assist in clinical trial enrollment.

Published
2018

3. Contents Vol. 91, 2016

Author

Masahiro Kobayashi, Eugene Ahn, Yoshiyuki Suzuki, Frédéric Marchal, Jo-Anne Vergilio, Lise Lecointre, Abul Kalam Najmi, Rachel L. Erlich, Ryoju Negishi, Hitomi Sezaki, Jean-Emmanuel Kurtz, George William Daneker, Julia A. Elvin, Vincent A. Miller, Pawan Kirtani, Glen J. Weiss, Yosuke Ando, Oliver Holmes, Jean-Jacques Baldauf, Karolina Afors, Siraj M. Ali, Kaori Ito, Norio Akuta, Sarina Anne Piha-Paul, Akira Tenmoku, Mariko Kobayashi, Nobuhiko Emi, Shigeki Yamada, Yasuji Arase, Fumitaka Suzuki, Carole Mathelin, Pramod Kumar Mishra, Cherif Akladios, Maurie Markman, Yoko Inaguma, Masahiro Tsuge, Anjali Singh, Caterina Vivaldi, Wei-Lien Wang, Maiko Ando, Alexa B. Schrock, Satz Mengensatzproduktion, Michel Hummel, Hiroshi Sasaki, Yukiko Kakumae, Masataka Okamoto, Ayana Tomono, Akinao Okamoto, Hiromitsu Kumada, Alfredo Falcone, Enrico Vasile, David L. Stockman, Thierry Petit, Ricardo H. Alvarez, Chiara Caparello, Masayuki A. Fujino, Sundeep Singh Saluja, Shunichiro Fujiyama, Kim Kramer, Satoshi Saitoh, Stéphanie Schrot-Sanyan, Jeffrey S. Ross, Gianna Musettini, James Suh, Itaru Oi, Druckerei Stückle, Iacopo Petrini, Giulia Pasquini, Takahiro Hayashi, Majid A. Talikoti, Takeshi Ichikawa, Behrang Amini, Ralph Zinner, Hiroaki Kaneko, Yusuke Kawamura, Kenji Ikeda, Daniel Spritz, Maria Alejandra Zarzour, Tetsuya Hosaka, Vivek Subbiah, Funda Meric-Bernstam, Laure-Emilie Rebstock, Monica Lencioni, Philip J. Stephens, Nobuaki Machida, Lorenzo Fornaro, and Kyle Gowen

Subjects
Cancer Research, Oncology, General Medicine
Published
2016

4. Acknowledgement to the Reviewers

Author

Hitomi Sezaki, Carole Mathelin, Kyle Gowen, Vivek Subbiah, Fumitaka Suzuki, Ayana Tomono, Lise Lecointre, Funda Meric-Bernstam, Hiroaki Kaneko, Stéphanie Schrot-Sanyan, Ralph Zinner, Yusuke Kawamura, Julia A. Elvin, Laure-Emilie Rebstock, Pawan Kirtani, Karolina Afors, Kenji Ikeda, Jeffrey S. Ross, Hiromitsu Kumada, Iacopo Petrini, Daniel Spritz, Maria Alejandra Zarzour, Jean-Jacques Baldauf, David L. Stockman, Frédéric Marchal, Jean-Emmanuel Kurtz, Maiko Ando, Nobuhiko Emi, Enrico Vasile, Takeshi Ichikawa, Chiara Caparello, Mariko Kobayashi, Glen J. Weiss, Yosuke Ando, Vincent A. Miller, Masahiro Kobayashi, Kaori Ito, Nobuaki Machida, Itaru Oi, Yoshiyuki Suzuki, Akira Tenmoku, Behrang Amini, Oliver Holmes, Giulia Pasquini, Takahiro Hayashi, Alexa B. Schrock, Yasuji Arase, Masataka Okamoto, Pramod Kumar Mishra, Masahiro Tsuge, Hiroshi Sasaki, Akinao Okamoto, Monica Lencioni, Caterina Vivaldi, Abul Kalam Najmi, Anjali Singh, Philip J. Stephens, Sarina Anne Piha-Paul, George William Daneker, Tetsuya Hosaka, Satoshi Saitoh, Lorenzo Fornaro, Thierry Petit, Cherif Akladios, Norio Akuta, Maurie Markman, Wei-Lien Wang, James Suh, Yoko Inaguma, Kim Kramer, Ricardo H. Alvarez, Satz Mengensatzproduktion, Michel Hummel, Yukiko Kakumae, Masayuki A. Fujino, Gianna Musettini, Druckerei Stückle, Majid A. Talikoti, Sundeep Singh Saluja, Shunichiro Fujiyama, Eugene Ahn, Jo-Anne Vergilio, Ryoju Negishi, Siraj M. Ali, Shigeki Yamada, Rachel L. Erlich, and Alfredo Falcone

Subjects
Cancer Research, Medical education, Oncology, Acknowledgement, General Medicine, Psychology
Published
2014

Catalog

Books, media, physical & digital resources
See catalog results