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Start Over Author "La Porta, Maria Rosa" Journal oncology
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2. Management of 'In-Field' Skin Toxicity in Head and Neck Cancer Patients Treated with Combined Cetuximab and Radiotherapy.

Author

Cante, Domenico, La Porta, Maria Rosa, Franco, Pierfrancesco, Sciacero, Piera, Girelli, Giuseppe Franco, Marra, Annamaria, Numico, Gianmauro, Denaro, Nerina, Russi, Elvio Grazioso, and Ricardi, Umberto

Subjects
*HEAD tumors, *NECK tumors, *EPIDERMAL growth factor, *IMMUNOGLOBULINS, *INFORMATION storage & retrieval systems, *MEDICAL databases, *MEDICAL information storage & retrieval systems, *MEDLINE, *ONLINE information services, *PHOSPHOTRANSFERASES, *RADIOTHERAPY, *SKIN inflammation, *SOCIAL services case management, *CHEMICAL inhibitors, *SYMPTOMS, *TUMOR treatment
Abstract

It is well known that the cetuximab (Cet) epidermal growth factor receptor (EGFR) antibody enhances the sensitivity of tumour cells to radiation, and it is likely that the concurrent administration of Cet and radiotherapy (RT) results in some degree of interplay between the effects of the individual agents on the skin and in the exacerbation of reactions normally seen with these individual agents. In this paper, we present a concise review of Cet/RT-related skin toxicity, focusing on mechanisms and pathogenesis, clinical presentation and scoring systems and, finally, therapeutic management. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2013
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