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Your search keyword '"Elena, Collovà"' showing total 3 results
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3 results on '"Elena, Collovà"'

1. Contents Vol. 75, 2008

Author

G. Viola, Hiroshi Nokihara, rd Seaborn McDonald Wade, Massimo Lopez, Antonio Scilimati, Tomas Martinez, Erica Travaglino, Maria Grazia Perrone, Joseph Levy, Sanyuan Hu, Chiara Benatti, Guo-hua Zeng, Doron Amichay, Fei Yan, Yuichiro Ohe, Thomas L. Borok, F. Fanfani, Mary Helen Hackney, Fairooz F. Kabbinavar, D. Lorusso, Xia Zhao, A. Giordano, Rosangela Invernizzi, Howard Lee, Qifeng Yang, Ami Goradia, Serena Corsetti, Hanshuo Yang, Xue-cheng Bi, Wei-jun Qin, Zeev Barvish, Lijuan Chen, P. Foggi, James Welsh, Yu-xiang Liang, Richard Dodel, Michael Weller, Martin Glas, Marco Danova, Dorothee Wiewrodt, Paul Vos, Donatella Grasso, Ulrich Herrlinger, Vincent Vinh-Hung, Ulf Karlsson, Yuquan Wei, Yong-kang Ye, Ze Zhang, Katja Rasch, A. Fagotti, Francesco Giotta, Hagar Sharabani, Michael Bacher, Alberto Riccardi, Alison W. Loren, Wei-de Zhong, Luca Livraghi, Russell J. Hamilton, Tiantian Wang, Harukaze Yamamoto, Herbert Hurwitz, Birgit Rinn, Kestutis Suziedelis, G. Vizzielli, Luigi Di Lauro, Haidong Gao, M. Manzoni, Gang Zhu, Maria Notarnicola, James Khatcheressian, Feng Li, Qingbo Su, Rong Ma, C. Rossitto, Cornelia Irl, Zhenhua Pan, Michael Danilenko, A. De Gaetano, Alfredo Zurlo, Hideo Kunitoh, Ayelet Shabtay, Pertti Mutanen, Kirsti Husgafvel-Pursiainen, Selina M. Luger, Diana Giannarelli, George P. Studzinski, Noboru Yamamoto, G. Scambia, Qi-shan Dai, Valeria Tutino, Deirdre Cohen, Yoav Sharoni, Fan Yang, Marcella Mottolese, Nam P. Nguyen, Laurie J. Lyckholm, Ikuo Sekine, Jan-Philipp Bach, Claudio Botti, Maria Gabriella Caruso, Bernhard Meyer, Zhi-nan Chen, Nga T. T. Nguyen, Vikram R. Paralkar, Ly M. Nguyen, Zhiyong Qian, Domenico Sergi, Kristina Kurgonaite, Zhao-dong Han, Silvia Ileana Fattoruso, Tomohide Tamura, Hongxin Deng, Patrizia Vici, Michael Kafka, Hui-chan He, Kazuhiko Yamada, Elena Collovà, Milan R. Uskokovic, Zhengyu Li, Sonata Jarmalaite, and Feliksas Jankevičius

Subjects
Cancer Research, Oncology, General Medicine
Published
2008

2. Biological Effects of Pegfilgrastim on Circulating Neutrophils in Breast Cancer Patients Undergoing Dose-Dense Chemotherapy

Author

Luca Livraghi, Chiara Benatti, Donatella Grasso, M. Manzoni, Marco Danova, Alberto Riccardi, Erica Travaglino, Rosangela Invernizzi, and Elena Collovà

Subjects
Cancer Research, Filgrastim, Dose-dense chemotherapy, Neutrophils, medicine.medical_treatment, Apoptosis, Breast Neoplasms, Buffy coat, Biology, Polyethylene Glycols, Leukocyte Count, Antineoplastic Combined Chemotherapy Protocols, Granulocyte Colony-Stimulating Factor, In Situ Nick-End Labeling, medicine, Humans, Breast, Aged, Cell Proliferation, Chemotherapy, General Medicine, Middle Aged, Alkaline Phosphatase, Actin cytoskeleton, Actins, Recombinant Proteins, Granulocyte colony-stimulating factor, Oncology, Immunology, Absolute neutrophil count, Cancer research, Female, Pegfilgrastim, medicine.drug
Abstract

Pegfilgrastim is a covalent conjugate of filgrastim and polyethylene glycol that has proved to be effective in supporting myelopoiesis during chemotherapy. Since very limited information is available on the biological effects of pegfilgrastim on neutrophils exposed to chemotherapy, we analyzed the following parameters in neutrophils of patients undergoing dose-dense chemotherapy for breast cancer: apoptosis, by a TUNEL technique; actin polymerization, using FITC-labeled phalloidin, and alkaline phosphatase activity by cytochemistry. Peripheral blood buffy coat smears were obtained before starting treatment and immediately before each chemotherapy course. After pegfilgrastim stimulation we observed the following: (1) stability of the absolute neutrophil count for the whole duration of treatment and no infectious events; (2) a reduction in the neutrophil constitutive apoptosis rate in comparison with that observed in control patients treated with standard chemotherapy courses with no growth factor support; (3) persistent abnormalities of actin assembly in neutrophils, indicative of changes in cytoskeletal organization, and (4) a significant increase in the activity of leukocyte alkaline phosphatase, a sensitive marker of the later stages of neutrophil maturation. In conclusion, these results suggest that pegfilgrastim improves the neutrophil functions in patients exposed to chemotherapy by inhibition of constitutive apoptosis, thereby prolonging the survival of these cells.

Published
2008

3. Subject Index Vol. 75, 2008

Author

Hagar Sharabani, Ulrich Herrlinger, C. Rossitto, Michael Danilenko, Ayelet Shabtay, George P. Studzinski, Noboru Yamamoto, Deirdre Cohen, Tomas Martinez, Harukaze Yamamoto, Michael Kafka, Birgit Rinn, Yuichiro Ohe, Elena Collovà, Milan R. Uskokovic, Diana Giannarelli, Lijuan Chen, Xia Zhao, Ze Zhang, Sonata Jarmalaite, Chiara Benatti, James Welsh, Michael Bacher, Alfredo Zurlo, Doron Amichay, Dorothee Wiewrodt, Ikuo Sekine, Zhiyong Qian, Selina M. Luger, Domenico Sergi, Thomas L. Borok, Herbert Hurwitz, Jan-Philipp Bach, Mary Helen Hackney, Marcella Mottolese, Nam P. Nguyen, Alberto Riccardi, Alison W. Loren, Fairooz F. Kabbinavar, Fan Yang, A. Giordano, Haidong Gao, Luca Livraghi, Silvia Ileana Fattoruso, Maria Notarnicola, James Khatcheressian, Yong-kang Ye, Kirsti Husgafvel-Pursiainen, Gang Zhu, Zhao-dong Han, Qingbo Su, Rong Ma, Hiroshi Nokihara, Erica Travaglino, Patrizia Vici, Sanyuan Hu, Tomohide Tamura, F. Fanfani, Hongxin Deng, Ly M. Nguyen, Maria Grazia Perrone, D. Lorusso, Joseph Levy, Xue-cheng Bi, Wei-jun Qin, Maria Gabriella Caruso, Kristina Kurgonaite, Rosangela Invernizzi, Marco Danova, Claudio Botti, Feng Li, Laurie J. Lyckholm, Richard Dodel, A. Fagotti, Donatella Grasso, Ulf Karlsson, Yuquan Wei, Paul Vos, Hideo Kunitoh, Tiantian Wang, Martin Glas, Zhenhua Pan, Howard Lee, Zhi-nan Chen, Nga T. T. Nguyen, Bernhard Meyer, Hanshuo Yang, Vikram R. Paralkar, Kestutis Suziedelis, M. Manzoni, Qifeng Yang, A. De Gaetano, G. Vizzielli, Michael Weller, P. Foggi, Katja Rasch, Kazuhiko Yamada, Zeev Barvish, rd Seaborn McDonald Wade, Massimo Lopez, Pertti Mutanen, G. Viola, G. Scambia, Fei Yan, Luigi Di Lauro, Francesco Giotta, Antonio Scilimati, Guo-hua Zeng, Hui-chan He, Cornelia Irl, Vincent Vinh-Hung, Zhengyu Li, Feliksas Jankevičius, Ami Goradia, Serena Corsetti, Yu-xiang Liang, Wei-de Zhong, Russell J. Hamilton, Qi-shan Dai, Valeria Tutino, and Yoav Sharoni

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), General Medicine, Mathematics
Published
2008

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