1. Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers.
- Author
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Honma, Rio, Kinoshita, Ichiro, Miyoshi, Eiji, Tomaru, Utano, Matsuno, Yoshihiro, Shimizu, Yasushi, Takeuchi, Satoshi, Kobayashi, Yuka, Kaga, Kichizo, Taniguchi, Naoyuki, and Dosaka-Akita, Hirotoshi
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LUNG cancer prognosis , *ACADEMIC medical centers , *CHI-squared test , *CONFIDENCE intervals , *ENZYMES , *FISHER exact test , *IMMUNOHISTOCHEMISTRY , *LUNG cancer , *LUNG tumors , *MULTIVARIATE analysis , *RESEARCH funding , *SURVIVAL , *T-test (Statistics) , *WESTERN immunoblotting , *LOGISTIC regression analysis , *PROPORTIONAL hazards models , *DATA analysis software , *DESCRIPTIVE statistics , *KAPLAN-Meier estimator , *IN vitro studies , *LOG-rank test , *ODDS ratio - Abstract
Objecitive: Fucosyltransferase 8 (FUT8), the only enzyme responsible for the core α1,6-fucosylation of asparagine-linked oligosaccharides of glycoproteins, is a vital enzyme in cancer development and progression. We examined FUT8 expression in non-small cell lung cancers (NSCLCs) to analyze its clinical significance. We also examined the expression of guanosine diphosphate-mannose-4,6-dehydratase (GMD), which is imperative for the synthesis of fucosylated oligosaccharides. Methods: Using immunohistochemistry, we evaluated the expression of FUT8 and GMD in relation to patient survival and prognosis in potentially curatively resected NSCLCs. Results: High expression of FUT8 was found in 67 of 129 NSCLCs (51.9%) and was significantly found in non-squamous cell carcinomas (p = 0.008). High expression of FUT8 was associated with poor survival (p = 0.03) and was also a significant and independent unfavorable prognostic factor in patients with potentially curatively resected NSCLCs (p = 0.047). High expression of GMD was significantly associated with high FUT8 expression (p = 0.04). Conclusions: High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor. The analysis of FUT8 expression and its core fucosylated products may provide new insights for the therapeutic targets of NSCLCs. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2015
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