Descriptor: "basal breast cancer" / Journal: oncoimmunology - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"basal breast cancer"' showing total 2 results

Start Over Descriptor "basal breast cancer" Journal oncoimmunology

Author: Velasco-Velázquez, Marco and Pestell, Richard G.
Subjects: *CCL5 (Chemokine), *CANCER patients, *CANCER treatment, *METASTASIS, *CANCER invasiveness
Abstract: Recently, we have shown that the CCL5/CCR5 axis is active in patients affected by an aggressive basal subtype of breast cancer. Using preclinical models, we have demonstrated that CCR5 promotes breast cancer invasiveness and metastatic potential, while CCR5 inhibition abrogates them. Thus, CCR5 antagonists may constitute an alternative therapeutic approach for patients affected by metastatic basal breast cancer. [ABSTRACT FROM AUTHOR]
Published: 2013
Full Text: View/download PDF

Author: Marco A. Velasco-Velázquez and Richard G. Pestell
Subjects: CA15-3, Pathology, medicine.medical_specialty, viruses, Vicriviroc, Immunology, CCL5, Metastasis, Maraviroc, 03 medical and health sciences, Basal (phylogenetics), Therapeutic approach, 0302 clinical medicine, Breast cancer, medicine, Immunology and Allergy, metastasis, In patient, skin and connective tissue diseases, Author's View, 030304 developmental biology, 0303 health sciences, business.industry, virus diseases, medicine.disease, 3. Good health, basal breast cancer, Oncology, 030220 oncology & carcinogenesis, Cancer research, business, CCR5, medicine.drug
Abstract: Recently, we have shown that the CCL5/CCR5 axis is active in patients affected by an aggressive basal subtype of breast cancer. Using preclinical models, we have demonstrated that CCR5 promotes breast cancer invasiveness and metastatic potential, while CCR5 inhibition abrogates them. Thus, CCR5 antagonists may constitute an alternative therapeutic approach for patients affected by metastatic basal breast cancer.
Published: 2013

Books, media, physical & digital resources

Searchworks