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Your search keyword '"DNA-PKcs"' showing total 437 results

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437 results on '"DNA-PKcs"'

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1. CRL4ADTL degrades DNA-PKcs to modulate NHEJ repair and induce genomic instability and subsequent malignant transformation

5. CRL4A DTL degrades DNA-PKcs to modulate NHEJ repair and induce genomic instability and subsequent malignant transformation.

7. Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection.

8. Differential stability of the DNA-activated protein kinase catalytic subunit mRNA in human glioma cells.

9. DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues.

10. Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.

12. Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells.

13. The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents.

14. DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.

15. The life and death of DNA-PK.

16. The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit.

18. Glioblastoma multiforme: the role of DSB repair between genotype and phenotype.

19. Human normal peripheral blood B-lymphocytes are deficient in DNA-dependent protein kinase activity due to the expression of a variant form of the Ku86 protein.

20. Regulation of DNA-dependent protein kinase activity in leukemic cells.

21. SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization.

22. Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma.

23. Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.

24. Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants.

26. The Ku70-SIX1-GPT2 axis regulates alpha-ketoglutarate metabolism to drive progression of prostate cancer.

27. AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.

28. Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.

29. Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

30. Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract.

31. Regulation and mechanisms of mammalian double-strand break repair.

32. Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA.

33. The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

34. Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.

35. Modulation of DNA double-strand break repair as a strategy to improve precise genome editing.

36. Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer.

37. Targeting MEK5 impairs nonhomologous end-joining repair and sensitizes prostate cancer to DNA damaging agents.

38. The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer.

39. Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors.

40. Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3β-mediated cyclin D1 overexpression.

41. Non-homologous end-joining, a sticky affair.

42. V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.

43. Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice.

44. Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.

45. Reduced DNA-dependent protein kinase activity in two cell lines derived from adult cancer patients with late radionecrosis.

46. Ku affects the ATM-dependent S phase checkpoint following ionizing radiation.

47. Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines.

48. Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome.

49. Many ways to telomere dysfunction: in vivo studies using mouse models.

50. Inhibition of Ku heterodimer DNA end binding activity during granulocytic differentiation of human promyelocytic cell lines.

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