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1. Occupational exposure to wood dust and risk of lung cancer: the ICARE study

Author

Mireille, Matrat, Loredana, Radoï, Joëlle, Févotte, Florence, Guida, Sylvie, Cénée, Diane, Cyr, Marie, Sanchez, Gwenn, Menvielle, Annie, Schmaus, Emilie, Marrer, Danièle, Luce, Isabelle, Stücker, Corinne, Pilorget, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Mondor de médecine moléculaire (Im3), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Institut National Du Cancer, Fondation de France, Association pour la Recherche sur le Cancer, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Direction Générale de la Santé, Direction Générale du Travail, Santé Publique France, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Adult, Male, Risk, medicine.medical_specialty, Lung Neoplasms, Time Factors, Adolescent, Epidemiology, [SDV]Life Sciences [q-bio], Population, Logistic regression, medicine.disease_cause, complex mixtures, Asbestos, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Occupational Exposure, Surveys and Questionnaires, Medicine, Humans, 030212 general & internal medicine, Risk factor, Lung cancer, education, Aged, education.field_of_study, Inhalation Exposure, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Dust, Middle Aged, medicine.disease, 030210 environmental & occupational health, Wood, respiratory tract diseases, Occupational Diseases, Case-Control Studies, Female, Occupational exposure, France, business, Wood dust
Abstract

ObjectivesIn a previous analysis of data from a French population-based case–control study (the Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE) study), ‘having ever worked’ in wood-related occupations was associated with excess lung cancer risk after adjusting for smoking but not for occupational factors. The present study aimed to investigate the relationship between lung cancer risk and wood dust exposure after adjusting for occupational exposures.MethodsData were obtained from 2276 cases and 2780 controls on smoking habits and lifelong occupational history, using a standardised questionnaire with a job-specific questionnaire for wood dust exposure. Logistic regression models were used to calculate ORs and 95% CIs adjusted for age, area of residence, tobacco smoking, the number of job periods and exposure to silica, asbestos and diesel motor exhaust (DME).ResultsNo significant association was found between lung cancer and wood dust exposure after adjustment for smoking, asbestos, silica and DME exposures. The risk of lung cancer was slightly increased among those who were exposed to wood dust more than 10 years, and had over 40 years since the first exposure.ConclusionOur findings do not provide a strong support to the hypothesis that wood dust exposure is a risk factor for lung cancer. This study showed the importance of taking into account smoking and occupational coexposures in studies on lung cancer and wood dust exposure. Further studies evaluating the level and frequency of exposure during various tasks in woodwork are needed.

Published
2019
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2. Exposure to chlorinated solvents and lung cancer: results of the ICARE study

Author

Danièle Luce, Matthieu Carton, Gwenn Menvielle, Sylvie Cénée, Loredana Radoï, Francesca Mattei, Diane Cyr, Isabelle Stücker, Mireille Matrat, Fatima Jellouli, Marie Sanchez, Florence Guida, Emilie Marrer, Simona Bara, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Unité de pathologie professionnelle, CHI Créteil, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Registre des cancers de la Manche [CHPC - Site Louis Pasteur], Site Louis Pasteur [CHPC], CH Centre Hospitalier Public du Cotentin (CHPC)-CH Centre Hospitalier Public du Cotentin (CHPC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), FRANCIM, Réseau des registres français du cancer, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, Tetrachloroethylene, Lung Neoplasms, Trichloroethylene, [SDV]Life Sciences [q-bio], medicine.disease_cause, Logistic regression, Asbestos, Toxicology, chemistry.chemical_compound, Sex Factors, Risk Factors, Occupational Exposure, Environmental health, Odds Ratio, medicine, Humans, Risk factor, Lung cancer, Socioeconomic status, Aged, Methylene Chloride, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Middle Aged, medicine.disease, 3. Good health, Logistic Models, chemistry, Case-Control Studies, Carcinogens, Solvents, Etiology, Female, France, business
Abstract

International audience; OBJECTIVE: To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. METHODS: ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case-control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made. RESULTS: After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations. CONCLUSIONS: These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.

Published
2014
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3. Welding, a risk factor of lung cancer: the ICARE study

Author

Mireille, Matrat, Florence, Guida, Francesca, Mattei, Sylvie, Cénée, Diane, Cyr, Joëlle, Févotte, Marie, Sanchez, Gwenn, Menvielle, Loredana, Radoï, Annie, Schmaus, Anne-Sophie, Woronoff, Danièle, Luce, Isabelle, Stücker, Corinne, Pilorget, Unité de pathologie professionnelle, CHI Créteil, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Oral medicine and oral surgery department, Université Paris Descartes - Paris 5 (UPD5), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Francim : Réseau français des registres des cancers, CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement ( UMRESTTE ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Recherche sur les Transports et leur Sécurité ( INRETS ) -Institut de Veille Sanitaire (INVS), Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Descartes - Paris 5 ( UPD5 ), UMS 011, Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Institut National de la Santé et de la Recherche Médicale, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Registre général des cancers du Tarn, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPC), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement ( UMRESTTE UMR T9405 ), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux ( IFSTTAR ), Institut National de la Santé et de la Recherche Médicale-Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) ( CEF2P / CARCINO ), and Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté [COMUE] ( UBFC ) -Université de Franche-Comté ( UFC )

Subjects
Male, medicine.medical_specialty, Work, Lung Neoplasms, [SDV]Life Sciences [q-bio], Population, Welding, Air Pollutants, Occupational, medicine.disease_cause, Asbestos, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Risk Factors, Internal medicine, Occupational Exposure, Surveys and Questionnaires, Paint, medicine, Odds Ratio, Humans, Risk factor, Occupations, Lung cancer, education, Aged, education.field_of_study, [ SDV ] Life Sciences [q-bio], business.industry, Public Health, Environmental and Occupational Health, Case-control study, technology, industry, and agriculture, Odds ratio, respiratory system, Middle Aged, medicine.disease, 030210 environmental & occupational health, Surgery, Occupational Diseases, Logistic Models, 030220 oncology & carcinogenesis, Case-Control Studies, Gases, business, Risk assessment
Abstract

International audience; OBJECTIVES: We investigated the relationship between lung cancer and occupational exposure to welding activity in ICARE, a population-based case-control study. METHODS: Analyses were restricted to men (2276 cases, 2780 controls). Welding exposure was assessed through detailed questionnaires, including lifelong occupational history. ORs were computed using unconditional logistic regression, adjusted for lifelong cigarette smoking and occupational exposure to asbestos. RESULTS: Among the regular welders, welding was associated with a risk of lung cancer (OR=1.7, 95% CI 1.1 to 2.5), which increased with the duration (OR=2.0, 95% CI 1.0 to 3.9 when duration \textgreater10 years), and was maximum 10-20 years since last welding. The risk was more pronounced in case of gas welding (OR=2.0, 95% CI 1.2 to 3.3), when the workpiece was covered by paint, grease, or other substances (OR=2.0, 95% CI 1.2 to 3.4) and when it was cleaned with chemical substances before welding. No statistically significant increase in lung cancer risk was observed among occasional welders. CONCLUSIONS: Although these results should be confirmed, we showed that type of welding and mode of workpiece preparation are important determinants of the lung cancer risk in regular welders

Published
2015
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4. The joint effect of asbestos exposure, tobacco smoking and alcohol drinking on laryngeal cancer risk: evidence from the French population-based case-control study, ICARE

Author

Gwenn, Menvielle, Aurore, Fayossé, Loredana, Radoï, Florence, Guida, Marie, Sanchez, Matthieu, Carton, Diane, Cyr, Annie, Schmaus, Sylvie, Cénée, Joëlle, Fevotte, Patricia, Delafosse, Isabelle, Stücker, Danièle, Luce, Farida, Lamkarkach, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Hôpital Paul Brousse-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Oral medicine and oral surgery department, Université Paris Descartes - Paris 5 (UPD5), UMS 011, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), FRANCIM, Réseau des registres français du cancer, Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Descartes - Paris 5 ( UPD5 ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement ( UMRESTTE UMR T9405 ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux ( IFSTTAR ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité)

Subjects
Male, Alcohol Drinking, [SDV]Life Sciences [q-bio], Health Behavior, Alcohol, medicine.disease_cause, Asbestos, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Environmental health, Occupational Exposure, Tobacco, Odds Ratio, Medicine, Humans, Laryngeal Neoplasms, [ SDV ] Life Sciences [q-bio], Ethanol, business.industry, Smoking, Public Health, Environmental and Occupational Health, Absolute risk reduction, Case-control study, Cancer, Odds ratio, Middle Aged, medicine.disease, 030210 environmental & occupational health, 3. Good health, Occupational Diseases, Alcoholism, chemistry, 030220 oncology & carcinogenesis, Case-Control Studies, Occupational exposure, France, business, Cancer risk
Abstract

International audience; Objective The objective of the study was to investigate the joint effect of occupational exposure to asbestos, and tobacco and alcohol consumption, on the risk of laryngeal cancer among men. Methods We used data from a large population-based case–control study conducted in France. We estimated two-way and three-way interactions between asbestos exposure (never vs ever exposed), tobacco consumption (\textless20 vs ≥20 pack-years) and alcohol consumption (\textless5 vs ≥5 drinks per day). The interaction on an additive scale was assessed by estimating the relative excess risk due to interaction (RERI) and the attributable proportion due to interaction, and the interaction on a multiplicative scale was assessed by estimating the multiplicative interaction parameter (ψ). Multiplicative interactions were also assessed using fractional polynomials for alcohol drinking, tobacco smoking and asbestos exposure. Results When compared with light-to-moderate smokers and drinkers never exposed to asbestos, the increase in laryngeal cancer risk was smallest among light-to-moderate drinkers and smokers exposed to asbestos (OR=2.23 (1.08 to 4.60)), and highest among heavy smokers and drinkers ever exposed to asbestos (OR=69.39 (35.54 to 135.5)). We found an additive joint effect between asbestos exposure and alcohol consumption (RERI=4.75 (−4.29 to 11.12)), whereas we observed a more than additive joint effect between asbestos exposure and tobacco consumption (RERI=8.50 (0.71 to 23.81)), as well as between asbestos exposure, and tobacco and alcohol consumption (RERI=26.57 (11.52 to 67.88)). However, our results did not suggest any interaction on a multiplicative scale. Conclusions Our results suggest that asbestos exposure, in combination with tobacco and alcohol exposure, accounted for a substantial number of laryngeal cancer cases. Our findings therefore highlight the need for prevention in activities, such as construction work, where exposure to asbestos-containing materials remains

Published
2015
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5. Occupation and head and neck cancer: a population-based case-control study in France

Author

Loredana Radoï, Sylvie Cénée, Isabelle Stücker, Diane Cyr, Florence Guida, Kamel Wanzy, Sophie Paget-Bailly, Annie Schmaus, Alexandra Papadopoulos, Gwenn Menvielle, Danièle Luce, and Matthieu Carton

Subjects
BUILDING CARETAKERS, business.industry, Head and neck cancer, Confounding, Public Health, Environmental and Occupational Health, Large population, Case-control study, Population based, Logistic regression, medicine.disease, Preliminary analysis, Medicine, business, Demography
Abstract

Objectives To investigate the association between head and neck cancer (HNC) and occupation in men. Methods As part of a large population based case-control study conducted in France between 2002 and 2007 (the ICARE study), 1924 incident male HNC cases and 2780 male population controls were interviewed. Detailed lifetime occupational histories, as well as information on potential confounders were collected. A preliminary analysis based on job titles was performed. Odds-ratios (OR), adjusted for age, smoking and alcohol drinking, and 95% CIs were estimated using unconditional logistic regression. Results The risk of HNC was significantly increased for dry cleaners (OR: 6.9, 95% CI 1.5-30.9), building caretakers and cleaners (OR: 2.0, 95% CI: 1.2 to 3.2), rubber and plastics product makers (OR: 1.9, 95% CI: 1.1-3.4), metal processors (OR: 1.9, 95% CI: 1.2 to 3.0), bricklayers and other construction workers (OR:1.7 ; 95% CI :1.4 to 2.1), plumbers and welders (OR: 1.5, 95% CI: 1.2 to 2.0), food and beverages processors (OR:1.5, 95% CI:1.1-2.0), cooks and waiters (OR: 1.5, 95% CI: 1.1 to .2.1), painters (OR: 1.4, 95% CI: 1.0 to 2.1), material-handling and related equipment operators, dockers and freight handlers (OR: 1.3, 95% CI : 1.0 to 1.6), blacksmiths, toolmakers and machine-tool operators (OR: 1.3, 95% CI: 1.0 to 1.6). Teachers, managers and clerical workers had a significantly decreased risk. Conclusions These preliminary results suggest that occupational factors may play a substantial role in the risk of HNC. Assessment of exposure to several substances is in progress, and will help identify specific causal agents.

Published
2011
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6. 0220 Identification of short-term, long-term and lifelong DNA methylation markers of exposure to tobacco smoke: evidence from EPIC and NOWAC studies

Author

Roel Vermeulen, Florence Guida, Gianluca Campanella, Paolo Vineis, Torkjel M. Sandanger, Marc Chadeau-Hyam, and Eiliv Lund

Subjects
Genetics, Oncology, medicine.medical_specialty, 030505 public health, Confounding, Public Health, Environmental and Occupational Health, Cancer, Methylation, Epigenome, Biology, medicine.disease, Tobacco smoke, 3. Good health, European Prospective Investigation into Cancer and Nutrition, 03 medical and health sciences, 0302 clinical medicine, CpG site, Internal medicine, DNA methylation, medicine, 030212 general & internal medicine, 0305 other medical science
Abstract

Objectives The aim of our study is to validate and complement recently reported epigenetic biomarkers of exposure to tobacco smoke based on data from two cohorts and to characterise their prospective nature. Method We used case-control data from studies nested in two prospective cohorts: the Italian component of the European Prospective Investigation into Cancer and Nutrition study (N = 620) and the Norwegian Women and Cancer study (N = 382) as a validation dataset. For each of the participant, genome wide methylation profiles were acquired from blood samples collected at enrolment using the Illumina HM450 DNA methylation array. We performed epigenome wide association studies within each dataset to assess the relation between methylation levels and smoking-related variables, controlling for technical variation (batch effects) and confounding factors (including white blood cell composition). Results We found 8 and 897 CpG sites differentially methylated in former and current smokers, while compared to never smokers, respectively. The 8 candidate markers of former smoking showed a gradual reversion of their methylation levels from those typical of current smokers to those of never smokers. Further analyses using cumulative (over varying time windows) smoking intensities, highlighted three classes of biomarkers: short and long term biomarkers (measuring the effect of smoking in the past 10, and in the past 10 to 30 years respectively), and lifelong biomarkers detected more than 30 years after quitting smoking. Conclusions Genome-wide DNA methylation profiles show promising abilities to detect short-term to lifelong biomarkers of tobacco smoke exposure and, more generally, to potentially identify time-varying biomarkers of exposure.

Published
2014
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7. 0139 Occupational exposure to chlorinated solvents and lung cancer: results from the ICARE study

Author

Joëlle Févotte, Danièle Luce, Marie Sanchez, Florence Guida, Isabelle Stücker, Sylvie Cénée, and Francesca Mattei

Subjects
medicine.medical_specialty, education.field_of_study, Chlorinated solvents, Trichloroethylene, business.industry, Population, Public Health, Environmental and Occupational Health, Odds ratio, medicine.disease, Logistic regression, Toxicology, chemistry.chemical_compound, chemistry, Internal medicine, medicine, Carbon tetrachloride, Occupational exposure, business, Lung cancer, education
Abstract

Objectives We aimed to investigate the role of occupational exposure to chlorinated solvents in the aetiology of lung cancer. Method ICARE is a multicenter population-based case-control study conducted in France between 2001 and 2006. Information on subjects lifelong work history was collected by face to face interviews using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices (JEM) relative to five chlorinated solvents including trichloroethylene (TCE), methylene chloride, perchloroethylene (PER), chloroform and carbon tetrachloride. Solvents were studied separately and since overlapping among exposures analyses for combined solvents exposure were performed. In the questionnaire, subjects also had to report if they were exposed to TCE or other substances (PER was among them). Odds ratios (ORs) were computed using unconditional logistic regression models adjusted for classical risk factors. Results A total of 2926 cases (2276 men and 650 women) and 3555 controls (2780 men and 775 women) were included. A statistically significant positive association for lung cancer risk was observed in both men (OR 1.47, 95% CI: 1.00–2.17) and in women (OR 3.86, 95% CI: 1.36 -11.01) exposed to PER combined with TCE and/or methylene chloride. In contrast, no statistically significant associations were found for TCE or other solvent combinations. Finally for subjects, who reported the exposure to PER, the ORs were 3.25 (95% CI: 1.23, 8.59) and 3.12 (95% CI: 0.50, 19.28) among men and women respectively. Conclusions The results of this study suggest that PER alone or in combination with TCE and/or methylene chloride may increase the risk of lung cancer.

Published
2014
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8. 0234 Head and neck cancer and occupational exposure to asbestos, mineral wools and silica: results from the ICARE study

Author

Sophie Paget-Bailly, Matthieu Carton, Danièle Luce, Florence Guida, Isabelle Stücker, and Diane Cyr

Subjects
Larynx, Oncology, medicine.medical_specialty, business.industry, Head and neck cancer, Public Health, Environmental and Occupational Health, Cumulative Exposure, Cancer, Hypopharyngeal cancer, Odds ratio, medicine.disease_cause, medicine.disease, Asbestos, Confidence interval, Surgery, medicine.anatomical_structure, Internal medicine, Medicine, business
Abstract

Objectives To study the associations between head and neck cancer risk and occupational exposure to asbestos, mineral wools and silica. Method ICARE is a population based case-control study conducted in France. Analyses were restricted to men and included 1833 cases of head and neck squamous cell carcinomas (HNSCC) and 2747 controls. Complete occupational history was collected. Occupational exposures were assessed through job-exposure matrices. Logistic models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CI). Results Exposure to asbestos was associated with an elevated risk of HNSCC (OR=1.9, CI 1.6–2.3), and the risk increased significantly with the probability, duration and cumulative level of exposure. Significantly increased risks were found for all cancer sites: larynx (OR=2.1, CI 1.6–2.8), hypopharynx (OR=2.0 CI 1.5–2.8), oropharynx (OR=1.6 CI=1.3–2.1) and oral cavity (OR=1.9 CI 1.4–2.6). Conversely, after adjustment for asbestos exposure, exposure to mineral wools was not associated with HNSCC risk (OR=0.8 CI 0.6–1.0), for any of the cancer sites. Exposure to silica was not associated with HNSCC risk overall (OR=0.9 CI 0.7–1.2), but non-significantly elevated ORs were observed for the highest level of cumulative exposure for oropharyngeal (OR=1.6 CI 0.8–3.2) and hypopharyngeal cancer (OR=1.9 CI 0.9–4.1). Conclusions Our findings confirm the role of asbestos exposure in laryngeal cancer, and suggest that asbestos exposure increases also the risk of oral and pharyngeal cancer. There is some evidence of an association between silica exposure and pharyngeal cancer. Exposure to mineral wools was not associated with HNSCC risk in our study.

Published
2014
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9. 309 Lung cancer and exposure to silica and cement dusts: the ICARE

Author

Menvielle, Stücker, Cyr, Févotte, Florence Guida, Sanchez, Lamkarkach, Cénée, and Luce

Subjects
Cement, education.field_of_study, business.industry, Population, Public Health, Environmental and Occupational Health, Cumulative Exposure, medicine.disease, Logistic regression, medicine.disease_cause, Asbestos, Cancer registry, Cigarette smoking, Environmental health, medicine, education, Lung cancer, business
Abstract

Objectives This work aims at assessing the risk of lung cancer associated with exposures to silica and cement dusts, which are among the most frequent occupational exposures for construction workers. Methods ICARE is a large multicentre population-based case-control study conducted between 2001 and 2006 in 10 French departements with a general cancer registry. Complete occupational history was collected. The subjects’ exposures to silica and cement dusts were determined using two Job-Exposure Matrices (JEM) specific for these substances. We used unconditional logistic regression adjusted for age, department, number of job periods, lifelong cigarette smoking, and asbestos exposure (assessed using a third JEM). Results Analyses were conducted among men (1885 cases, 2368 controls) and concerned 18788 jobs. We found significant associations between the risk of lung cancer and exposure to silica (OR for ever exposure = 1.5[1.2–1.8]) and cement dust (OR for ever exposure = 1.8[1.4–2.2]). For both substances, risks are increasing with duration and cumulative exposure. Conclusions These results show a risk of lung cancer associated with exposures to silica and cement dust. Further analyses are ongoing to better understand their action in lung carcinogenesis.

Published
2013
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10. Lung cancer and exposure to mineral wools: the ICARE study

Author

Aude Lacourt, Sylvie Cénée, Danièle Luce, Isabelle Stücker, Stéphane Ducamp, Christophe Paris, Farida Lamkarkach, Joelle Fevotte, Patrick Brochard, Oumar Gaye, Florence Guida, and Diane Cyr

Subjects
Pathology, medicine.medical_specialty, education.field_of_study, business.industry, Population, Public Health, Environmental and Occupational Health, Logistic regression, medicine.disease_cause, medicine.disease, Asbestos, Cancer registry, Cigarette smoking, Environmental health, medicine, business, education, Lung cancer, Exposure assessment
Abstract

Objectives This work aims at assessing the risk of lung cancer associated with mineral wools (MW) currently used as a substitute for asbestos. They are suspected of increasing the risk of lung cancer because of their structure close to asbestos. Methods ICARE is a large multicentre population-based case-control study conducted between 2001 and 2006 in 10 French departments with a general cancer registry. ICARE includes 2926 incident lung cancer cases and 3555 controls with 78% of men. The subjects9 exposure to MW was first determined using a Job-Exposure Matrix (JEM) specific for MW. Then, individual exposure was assessed with an algorithm using specific questions on exposing tasks. We used unconditional logistic regression adjusted for age, department, number of job periods, lifelong cigarette smoking and exposure to asbestos (also assessed by a JEM and an algorithm). Results Analyses were conducted among men (2301 cases, 2780 controls) and concerned 27191 jobs. In the first analyses, we find significant associations between the risk of lung cancer and exposure to MW assessed with the JEM. They became non non-significant and close to 1 when adjusting for exposure to asbestos. In contrast, a significant dose-response relation was found between exposure to asbestos and the risk of lung cancer, even when adjusted for exposure to MW. Conclusions These results need to be completed with the exposure assessment from the algorithm. This algorithm would help us disentangle MW and asbestos exposure, which are closely related because of similar exposing jobs. Both results will be presented.

Published
2011
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