1. Serum 17beta-estradiol. Index of follicular maturation during gonadotropin therapy.
- Author
-
Notation AD, Tagatz GE, and Steffes MW
- Subjects
- Adult, Anovulation blood, Anovulation drug therapy, Chorionic Gonadotropin administration & dosage, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Menotropins administration & dosage, Menstruation, Chorionic Gonadotropin therapeutic use, Estradiol blood, Menotropins therapeutic use, Ovary growth & development
- Abstract
Thirteen patients with hypogonadotropic hypogonadism were treated with human menopausal gonadotropins (hMG) and human chorionic gonadotropin (hCG) to induce ovulation. Daily serum 17beta-estradiol (E2) assays were used to monitor the ovarian response to HMG. Apparent ovulation, documented by basal body temperatures, occurred in 41 of 53 hMG-hCG treatment cycles. Thirteen pregnancies occurred in 8 of the 13 patients. One twin pregnancy resulted. The hyperstimulation syndrome did not occur. Our data indicate that an optimal pregnancy rate with a minimum risk of hyperstimulation can be achieved when ovulation is induced 24 hours after the preovulatory serum E2 concentration has reached 500 to 900 pg/ml. Ovulation is induced by administering 10,000 IU and 5000 IU hCG on successive days. In addition, we now routinely give two or three injections of 2500 IU hCG at subsequent 3- to 4-day intervals to support the corpus luteum.
- Published
- 1978