1. Pattern of Expression of Adiponectin Receptors in Human Liver and its Relation to Nonalcoholic Steatohepatitis
- Author
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B. Solito, Monica Giannetti, A Bonotti, E Mancini, F Cecchetti, Eleuterio Ferrannini, Monica Nannipieri, Marco Anselmino, Ferruccio Santini, G Marchetti, Aldo Pinchera, and Simona Baldi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Intra-Abdominal Fat ,Endocrinology, Diabetes and Metabolism ,Receptor expression ,Interquartile range ,Internal medicine ,medicine ,Humans ,Obesity ,Receptor ,Nutrition and Dietetics ,Adiponectin ,business.industry ,Fatty liver ,nutritional and metabolic diseases ,Middle Aged ,medicine.disease ,Fatty Liver ,Endocrinology ,Diabetes Mellitus, Type 2 ,Liver ,Female ,Surgery ,Receptors, Adiponectin ,Steatosis ,business - Abstract
Adiponectin has antisteatosis–anti-inflammatory properties and its circulating levels are reduced in nonalcoholic steatohepatitis (NASH). To assess the role of adiponectin in NASH, we measured expression of adiponectin gene (APM1) and receptors (AdipoR1/AdipoR2) in liver and subcutaneous and visceral fat in subjects with biopsy-proven NASH or pure steatosis (PS). In 103 subjects undergoing gastric bypass or elective abdominal surgery (17 with normal liver histology (C), 52 with PS, and 34 with NASH), RNA was extracted from tissue samples, and quantification of APM1, AdipoR1, and AdipoR2 was carried out by real-time polymerase chain reaction. In NASH vs C, circulating adiponectin levels (3.6[2.4] vs 5.3[4.3] μg/ml, median[interquartile range], p
- Published
- 2008
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