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A recent study conducted by researchers at the University of Seville in Spain has found that morbid obesity is often accompanied by non-alcoholic fatty liver disease (NAFLD). The study examined the expression of genes related to reverse cholesterol transport and leptin receptor pathways in peripheral blood mononuclear cells (PBMCs) from patients with morbid obesity before and after gastric bypass surgery. The researchers discovered that the expression of these genes was decreased in patients with morbid obesity compared to non-obese subjects. The findings suggest that alterations in these pathways may play a role in the development of NAFLD in morbidly obese individuals. [Extracted from the article]

A recent report discusses research on obesity, specifically the potential benefits of combining long-acting PYY and GLP-1 receptor agonists as a treatment. The study conducted on diet-induced obese mice found that the combination treatment resulted in increased expression of genes involved in appetite regulation and improved sensitivity to leptin. These findings suggest that the synergistic effects of PYY and GLP-1 receptor agonists may contribute to weight loss. The research was conducted by Novo Nordisk and funded by the Innovation Fund. [Extracted from the article]

A recent study conducted by researchers at the University of Iowa explores the role of the central autonomic network in the development of obesity-induced hypertension. The study focuses on the leptin receptor neurons and their involvement in cardiovascular and metabolic regulation. Through experiments on mice, the researchers identified shared neurons in various brain regions associated with the kidneys, liver, and brown adipose tissue. The findings suggest that leptin may play a role in coupling cardiovascular and metabolic functions through a small number of neurons in the central nervous system. [Extracted from the article]

Researchers from Slovak University of Agriculture in Nitra conducted a study to analyze genetic polymorphisms in genes encoding leptin receptor (LEPR) and ghrelin (GHR) as genetic markers of metabolic disorders in human nutrition. They obtained genomic DNA from 84 human blood samples and used the PCR-RFLP method to identify SNPs in the LEPR and GHR genes. The study found a significant association between the genetic markers and levels of LDL cholesterol, suggesting that these genes may be involved in lipid metabolism disorders and obesity. Further research is needed to explore the role of these genes in nutritional status. [Extracted from the article]

Researchers at Regeneron Pharmaceuticals Inc. have conducted a phase I study on mibavademab, a monoclonal antibody being investigated for the treatment of conditions associated with leptin deficiency. The study involved healthy participants who received single-ascending doses or multiple doses of mibavademab. The researchers found that mibavademab pharmacokinetics were nonlinear with target-mediated elimination, and there were no dose-dependent differences in total soluble leptin receptor levels. They also observed that participants with lower baseline leptin levels had lower mean mibavademab concentrations, higher mean total soluble leptin receptor concentrations, and larger decreases in body weight. The study concluded that mibavademab shows promise for the treatment of conditions associated with leptin deficiency. [Extracted from the article]

Researchers from the Slovak University of Agriculture conducted a study to identify gene polymorphisms in the Leptin and Ghrelin receptors in the human population. Leptin is a hormone that plays a role in energy metabolism and body weight, while Ghrelin is a hormone produced by the stomach that stimulates growth hormone secretion and enhances feeding and weight gain. The study included 35 human samples, and the researchers used specific restriction enzymes to analyze the gene polymorphisms. The researchers concluded that the identified gene mutation may be connected to human obesity levels. For more information, readers can refer to the article "Association Analysis of the Leptin and Ghrelin Receptor Gene Polymorphism in the Human with BMI" published in Scientific Papers Animal Science and Biotechnologies. [Extracted from the article]

A study conducted by researchers at the Kyrgyz State Medical Academy in Bishkek, Kyrgyzstan, aimed to investigate the association between a specific genetic polymorphism (Gln223Arg) of the leptin receptor gene and metabolic syndrome components in the Kyrgyz population. The study involved 237 Kyrgyz subjects aged 35-70 years, and various measurements such as anthropometric data, glucose, insulin, lipid spectrum, and leptin levels were obtained. The results showed that the Gln223Arg polymorphism was associated with a higher risk of insulin resistance and higher levels of glycemia and insulinemia. However, no association was found with abdominal obesity, arterial hypertension, hypertriglyceridemia, or low-density cholesterol levels. The researchers concluded that further studies are needed to confirm these results in populations from other regions. [Extracted from the article]

A study conducted at the University of Oxford in the United Kingdom has found that a population of cells called immunomodulatory leptin receptor-positive (LepR+) sympathetic perineurial barrier cells (SPCs) play a role in protecting against obesity. These cells are present in both mice and humans and are involved in regulating brown adipose tissue (BAT) thermogenesis. The researchers discovered that mice lacking IL33 in SPCs had increased inflammation in BAT and were more susceptible to diet-induced obesity. This study highlights the connection between leptin, immune regulation, and body weight, bridging the gap between neuroendocrinology and immunometabolism in obesity research. [Extracted from the article]

A recent study conducted by Regeneron Pharmaceuticals Inc. has explored the use of a monoclonal antibody called REGN4461 as a potential treatment for lipodystrophy, a condition characterized by the loss of fat tissue. The study found that REGN4461 was able to normalize body weight, food intake, blood glucose, and insulin sensitivity in obese mice lacking the hormone leptin. In addition, the antibody alleviated various symptoms associated with lipodystrophy in a mouse model. The researchers also reported positive results from a phase 1 clinical trial and compassionate-use treatment of a patient with lipodystrophy. These findings suggest that REGN4461 may be a promising therapeutic option for individuals with low leptin concentrations. [Extracted from the article]

A recent report discusses research on bladder cancer, which is one of the ten most common tumors globally. The study focused on the association between obesity and bladder cancer risk, specifically examining the levels of leptin and its receptor in patients. The research found that bladder cancer patients had higher levels of leptin and lower levels of the leptin receptor. Additionally, certain genetic variants in the LEPR gene were associated with bladder cancer. The findings suggest that lifestyle changes and disturbances in energy metabolism may play a role in the development of bladder cancer. [Extracted from the article]

For more information on this research see: Congenital leptin receptor deficiency: A novel leptin receptor gene mutation in an Indian family producing severe early-onset monogenic obesity. Keywords: Adipokine Receptors; Adipokines; Bariatrics; Diet and Nutrition; Genetics; Health and Medicine; Intercellular Signaling Peptides and Proteins; Leptin; Leptin Receptors; Membrane Proteins; Nutrition Disorders; Nutritional and Metabolic Diseases and Conditions; Obesity; Overnutrition EN Adipokine Receptors Adipokines Bariatrics Diet and Nutrition Genetics Health and Medicine Intercellular Signaling Peptides and Proteins Leptin Leptin Receptors Membrane Proteins Nutrition Disorders Nutritional and Metabolic Diseases and Conditions Obesity Overnutrition 1399 1399 1 09/25/23 20230925 NES 230925 2023 SEP 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on obesity have been published. [Extracted from the article]

Our news correspondents obtained a quote from the research from Capital Medical University: "Moreover, the role of leptin/leptin receptors axis in obesity and the prognosis of CP is still unknown. Keywords: Adipokines; Bariatrics; Craniopharyngiomas; Diet and Nutrition; Genetics; Health and Medicine; Intercellular Signaling Peptides and Proteins; Leptin; Nutrition Disorders; Nutritional and Metabolic Diseases and Conditions; Obesity; Overnutrition; Risk and Prevention EN Adipokines Bariatrics Craniopharyngiomas Diet and Nutrition Genetics Health and Medicine Intercellular Signaling Peptides and Proteins Leptin Nutrition Disorders Nutritional and Metabolic Diseases and Conditions Obesity Overnutrition Risk and Prevention 186 186 1 07/24/23 20230728 NES 230728 2023 JUL 28 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on obesity have been presented. [Extracted from the article]

Valladolid, Spain, Europe, Adipokine Receptors, Adipokines, Abdominal Obesity, Bariatrics, Diet and Nutrition, Diseases and Conditions, Genetics, Health and Medicine, Healthcare, Intercellular Signaling Peptides and Proteins, Leptin, Leptin Receptors, Membrane Proteins, Metabolic Syndrome, Nutrition Disorders, Nutritional and Metabolic Diseases and Conditions, Obesity, Overnutrition, Peptide Hormones, Peptide Proteins, Proinsulin, Risk and Prevention Keywords: Valladolid; Spain; Europe; Abdominal Obesity; Adipokine Receptors; Adipokines; Bariatrics; Diet and Nutrition; Diseases and Conditions; Genetics; Health and Medicine; Healthcare; Intercellular Signaling Peptides and Proteins; Leptin; Leptin Receptors; Membrane Proteins; Metabolic Syndrome; Nutrition Disorders; Nutritional and Metabolic Diseases and Conditions; Obesity; Overnutrition; Peptide Hormones; Peptide Proteins; Proinsulin; Risk and Prevention EN Valladolid Spain Europe Abdominal Obesity Adipokine Receptors Adipokines Bariatrics Diet and Nutrition Diseases and Conditions Genetics Health and Medicine Healthcare Intercellular Signaling Peptides and Proteins Leptin Leptin Receptors Membrane Proteins Metabolic Syndrome Nutrition Disorders Nutritional and Metabolic Diseases and Conditions Obesity Overnutrition Peptide Hormones Peptide Proteins Proinsulin Risk and Prevention 271 271 1 06/19/23 20230623 NES 230623 2023 JUN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Nutritional and Metabolic Diseases and Conditions - Abdominal Obesity have been presented. [Extracted from the article]

Keywords: Adipokine Receptors; Adipokines; Cancer; Colon Cancer; Colorectal Research; Gastroenterology; Health and Medicine; Intercellular Signaling Peptides and Proteins; Leptin; Leptin Receptors; Membrane Proteins; Oncology; Risk and Prevention EN Adipokine Receptors Adipokines Cancer Colon Cancer Colorectal Research Gastroenterology Health and Medicine Intercellular Signaling Peptides and Proteins Leptin Leptin Receptors Membrane Proteins Oncology Risk and Prevention 1118 1118 1 03/27/23 20230331 NES 230331 2023 MAR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on colon cancer are presented in a new report. Strong leptin receptor expression and the prevalence of overweight and obesity are factors influencing the occurrence of excessive leptin concentrations.". [Extracted from the article]

Keywords: Santiago de Compostela; Spain; Europe; Adipokine Receptors; Adipokines; Intercellular Signaling Peptides and Proteins; Leptin; Leptin Receptors; Membrane Proteins EN Santiago de Compostela Spain Europe Adipokine Receptors Adipokines Intercellular Signaling Peptides and Proteins Leptin Leptin Receptors Membrane Proteins 2023 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Membrane Proteins - Adipokine Receptors are presented in a new report. Spain, Europe, Adipokine Receptors, Adipokines, Intercellular Signaling Peptides and Proteins, Leptin, Leptin Receptors, Membrane Proteins, Santiago de Compostela. [Extracted from the article]