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Investigators discuss in 'Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants' new findings in Apoptosis. 'Epithelial cell dysfunction is [...]

Current study results from the report, 'Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-ß,' have been published. 'Mutations in sarcomere protein genes can [...]

Fresh data on leukemia are presented in the report 'Conditional inactivation of MLH1 in thymic and naive T-cells in mice leads to a limited incidence of lymphoblastic T-cell lymphomas.' According [...]

A report, 'Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational status,' is newly published data in Human Pathology. According to recent research from [...]

Research findings, 'IL-13 upregulates GPIIb expression in megakaryocytic cell lines via STAT6,' are discussed in a new report. According to recent research from Nanchang, People's Republic of China, 'Interleukin 13 [...]

Research findings, 'Long-term follow-up of monoclonal B-cell lymphocytosis detected in environmental health studies,' are discussed in a new report. According to recent research published in the journal Cytometry Part B, [...]

Current study results from the report, 'Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma,' have been published. 'Janus kinase 1 (JAK1) and JAK3 plays a critical [...]

Investigators publish new data in the report 'Polycystin-1: function as a mechanosensor.' 'Polycystin-1 (PC1), encoded by the Pkd1 gene, is a large transmembrane protein whose mutation is involved in autosomal [...]

New investigation results, 'Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models,' are detailed in a study published in Neuroscience [...]

Investigators publish new data in the report 'Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function.' According to recent research from the United States, 'Infantile-onset Neuronal Ceroid Lipofuscinosis (INCL) [...]

Fresh data on intranuclear space are presented in the report 'Nuclear matrix protein (NRP/B) modulates the nuclear factor (Erythroid-derived 2)-related 2 (NRF2)-dependent oxidative stress response.' According to a study from [...]

According to a study from Heidelberg, Germany, 'In muscle cells, a complex network of Z-disc proteins allows proper reception, transduction and transmission of mechanical and biochemical signals. Mutations in genes [...]

Investigators publish new data in the report 'Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription.' According to recent research published in the [...]

Current study results from the report, 'The V510D suppressor mutation stabilizes DeltaF508-CFTR at the cell surface,' have been published. According to recent research published in the journal Biochemistry, 'Deletion of [...]

A report, 'Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia,' is newly published data in Haematologica. According to a study from Hirosaki, Japan, 'Diamond-Blackfan anemia is [...]

Research findings, 'Y Chromosome microdeletion and altered sperm quality in human males with high concentration of seminal hexachlorocyclohexane (HCH),' are discussed in a new report. According to recent research from [...]

According to a study from South Korea, 'The sea cucumber Stichopus japonicus is an important food and traditional medicine in Asian countries. However, ethyl acetate solvent fraction of S. japonicus [...]

Investigators publish new data in the report 'New insights into endocrine pancreatic development: the role of environmental factors.' According to a study from Paris, France, 'The pancreas is a mixed [...]

Researchers detail in 'Neutrophil granules in health and disease,' new data in internal medicine. 'Neutrophil granules store proteins that are critically important for the neutrophil to move from the vascular [...]

Research findings, 'Lyso-phosphatidylcholine induces osteogenic gene expression and phenotype in vascular smooth muscle cells,' are discussed in a new report. According to recent research from the United States, 'Calcifying vascular [...]

Current study results from the report, 'Generating retinal neurons by reprogramming retinal pigment epithelial cells,' have been published. 'IMPORTANCE OF THE FIELD: Retinal degenerations cause blindness. One potential therapy is [...]

Current study results from the report, 'Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy,' have been published. According to recent research published in the [...]

Fresh data on tooth disease are presented in the report 'Transient leukoencephalopathy associated with X-linked Charcot-Marie-Tooth disease.' 'X-linked hereditary demyelinating neuropathy (Charcot-Marie-Tooth 1X) accounts for 10% to 20% of all [...]

A report, 'Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice,' is newly published data in The Journal of Clinical Investigation. 'Mutations in the tumor-suppressor [...]

Investigators publish new data in the report 'Transcriptional regulation of bone sialoprotein gene by Porphyromonas gingivalis lipopolysaccharide.' According to recent research published in the Journal of Cellular Biochemistry, 'Lipopolysaccharide (LPS) [...]

A new study, 'Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion,' is now available. According to recent research [...]

According to a study from Stavanger, Norway, 'Mutations in the DJ-1 gene (also known as PARK7) cause inherited Parkinson's disease, which is characterized by neuronal death. Although DJ-1 is thought [...]

Scientists discuss in 'Low penetrance of Leber's hereditary optic neuropathy in ten Han Chinese families carrying the ND6 T11484C mutation' new findings in neuropathy. 'Leber's hereditary optic neuropathy (LHON) is [...]

Current study results from the report, 'A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover,' have been published. 'Charcot-Marie-Tooth disease type 2A (CMT2A) [...]

A new study, 'The role of the Fe-S cluster in the sensory domain of nitrogenase transcriptional activator VnfA from Azotobacter vinelandii,' is now available. 'Transcriptional activator VnfA is required for [...]

New research, 'Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination,' is the subject of a report. According to a study from [...]

Current study results from the report, 'Loss of Hda activity stimulates replication initiation from I-box, but not R4 mutant origins in Escherichia coli,' have been published. 'Initiation of chromosome replication [...]

Cyclic AMP response element-binding protein positively regulates interferon-gamma production by T cells that respond to Mycobacterium tuberculosis. 'IFN-gamma is essential for resistance to many intracellular pathogens, including Mycobacterium tuberculosis. Transcription [...]