1. Main characteristics of metabolically obese normal weight and metabolically healthy obese phenotypes.
- Author
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Teixeira, Tatiana F. S., Alves, Raquel D. M., Moreira, Ana Paula B., and Peluzio, Maria do Carmo G.
- Subjects
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FAT cells , *GUT microbiome , *METABOLIC syndrome risk factors , *GENES , *ADIPOSE tissues , *AGE distribution , *BODY composition , *BODY weight , *HUMAN body composition , *C-reactive protein , *FATTY acids , *FATTY liver , *HEALTH , *HOMEOSTASIS , *HYPERINSULINISM , *HYPERLIPIDEMIA , *HYPERTENSION , *INFLAMMATION , *INSULIN resistance , *INTERLEUKINS , *LIVER , *LOW density lipoproteins , *LOW-fat diet , *MATHEMATICAL models , *MEDLINE , *OBESITY , *ONLINE information services , *RESEARCH funding , *TRIGLYCERIDES , *TUMOR necrosis factors , *WEIGHT loss , *PHENOTYPES , *DNA-binding proteins , *SYSTEMATIC reviews , *EVIDENCE-based medicine , *LEPTIN , *THEORY , *PROFESSIONAL practice , *METABOLIC syndrome , *BODY mass index , *WAIST-hip ratio , *WAIST circumference , *PHYSIOLOGY - Abstract
In this review, the influence of fat depots on insulin resistance and the main characteristics of metabolically obese normal-weight and metabolically healthy obese phenotypes are discussed. Medline/PubMed and Science Direct were searched for articles related to the terms metabolically healthy obesity, metabolically obese normal weight, adipose tissue, and insulin resistance. Normal weight and obesity might be heterogeneous in regard to their effects. Fat distribution and lower insulin sensitivity are the main factors defining phenotypes within the same body mass index. Although these terms are interesting, controversies about them remain. Future studies exploring these phenotypes will help elucidate the roles of adiposity and/or insulin resistance in the development of metabolic alterations. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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