1. Ingested hyaluronan moisturizes dry skin
- Author
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Hideto Yoshida, Chinatsu Kawada, Toshihide Sato, Tomoyuki Kanemitsu, Ryosuke Matsuoka, Takushi Yoshida, Yasunobu Masuda, Osamu Urushibata, Wakako Sakamoto, Takeshi Yamasaki, and Wataru Odanaka
- Subjects
Dry skin ,Pathology ,medicine.medical_specialty ,Hyaluronic acid ,Treatment outcome ,Dietary supplement ,Moisturizing ,Administration, Oral ,Medicine (miscellaneous) ,Review ,Absorption (skin) ,Skin Diseases ,Clinical study ,chemistry.chemical_compound ,medicine ,Humans ,Ingestion ,Food science ,Hyaluronan ,Cell Proliferation ,Randomized Controlled Trials as Topic ,Skin ,Nutrition and Dietetics ,integumentary system ,business.industry ,Fibroblasts ,Skin Care ,Pharmacological action ,chemistry ,Quality of Life ,medicine.symptom ,business - Abstract
Hyaluronan (HA) is present in many tissues of the body and is essential to maintain moistness in the skin tissues, which contain approximately half the body's HA mass. Due to its viscosity and moisturizing effect, HA is widely distributed as a medicine, cosmetic, food, and, recently marketed in Japan as a popular dietary supplement to promote skin moisture. In a randomized, double-blind, placebo-controlled clinical study it was found that ingested HA increased skin moisture and improved treatment outcomes for patients with dry skin. HA is also reported to be absorbed by the body distributed, in part, to the skin. Ingested HA contributes to the increased synthesis of HA and promotes cell proliferation in fibroblasts. These effects show that ingestion of HA moisturizes the skin and is expected to improve the quality of life for people who suffer from dry skin. This review examines the moisturizing effects of dry skin by ingested HA and summarizes the series of mechanisms from absorption to pharmacological action.
- Published
- 2014