1. Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes
- Author
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Nicholas T. Broskey, Charmaine S. Tam, Elizabeth F. Sutton, Abby D. Altazan, Jeffrey H. Burton, Eric Ravussin, and Leanne M Redman
- Subjects
Polycystic ovary syndrome ,Metabolic flexibility ,Substrate oxidation ,Insulin resistance ,Hyperinsulinemic euglycemic clamp ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background An ability to switch between primarily oxidizing fat in the fasted state to carbohydrate in the fed state, termed metabolic flexibility, is associated with insulin sensitivity. Metabolic flexibility has been explored previously in women with polycystic ovary syndrome (PCOS), yet the independent or synergistic contributions of androgen excess and/or insulin resistance is not yet known. Therefore, the purpose of this article was to characterize metabolic flexibility in women with PCOS compared to women of normal BMI, obesity, or type 2 diabetes (T2DM). Methods Eighty-six weight-stable women; thirty with either PCOS (n = 30), or fifty-six with obesity (n = 12), T2DM (n = 27), or normal BMI (n = 17) underwent a hyperinsulinemic euglycemic clamp and indirect calorimetry to measure insulin sensitivity and substrate oxidation via indirect calorimetry, respectively. Results All analyses were adjusted for differences in age, ethnicity, and BMI between groups. Women with PCOS were less metabolically flexible compared to healthy women with obesity (p
- Published
- 2018
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