1. Combined use of handgrip strength and hemoglobin as markers of undernutrition in patients with stage 3–5 chronic kidney disease.
- Author
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Lonardo, Maria Serena, Cacciapuoti, Nunzia, Chiurazzi, Martina, Di Lauro, Mariastella, Guida, Bruna, Damiano, Simona, and Cataldi, Mauro
- Abstract
The early identification of undernourished patients with CKD could help instating appropriate nutritional intervention before the full development of the threatening condition known as Protein Energy Wasting (PEW). Handgrip strength (HGS) and blood hemoglobin (Hb) concentration are two parameters considered representative of nutritional status but not included among the criteria for PEW diagnosis. In the present work we investigated whether they could help identifying CKD patients at risk of undernutrition. We performed a two-step cluster analysis to classify a cohort of 71 stage 3–5 CKD patients, none of which with PEW, according to their Hb concentration and dominant-hand HGS. Two clusters were finely separated using this method. When we compared the two groups for main body composition and nutritional variables by using t-test statistics or Mann–Whitney test, as appropriate, we found significant differences in PhA, ECW/TBW, ASMI, serum iron. Then we stratified our population by gender and performed cluster analysis as well. PhA, ECW/TBW were still significantly different in the two clusters both in M and in F, while serum iron concentration only in males and ASMI only in females. These results suggest that either in male than in female Hb concentration and HGS may distinguish two subgroups of CKD patients with different nutritional status and disease severity. Patient belonging to either of these cluster can be easily identified by using the HGS/Hb ratio which represents the HGS normalized per gr Hb. [Display omitted] • CKD patients often experience undernutrition to the extend of PEW or Sarcopenia • HGS and blood Hb are considered representative of nutritional status • 2-step cluster analysis using Hb and HGS to discriminate 3-5 CKD patients' nutritional status • Differences between the 2 clusters, stratified by gender, in PhA and ECW/TBW • Combined use of blood Hb and HGS discern patients with different nutritional status [ABSTRACT FROM AUTHOR]
- Published
- 2023
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