1. Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study.
- Author
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Companys J, Gosalbes MJ, Pla-Pagà L, Calderón-Pérez L, Llauradó E, Pedret A, Valls RM, Jiménez-Hernández N, Sandoval-Ramirez BA, Del Bas JM, Caimari A, Rubió L, and Solà R
- Subjects
- Actinobacteria growth & development, Actinobacteria isolation & purification, Adult, Bacteria isolation & purification, Body Mass Index, Clostridiales growth & development, Clostridiales isolation & purification, Cross-Sectional Studies, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Eating, Energy Intake, Feces microbiology, Female, Humans, Male, Middle Aged, Potassium administration & dosage, Bacteria classification, Diet, Gastrointestinal Microbiome, Obesity microbiology, Overweight microbiology, Thinness microbiology
- Abstract
We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens , Dorea formicigenerans and Dorea longicatena , which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas , a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia , a biomarker for the lean group. In conclusion, Dorea formicigenerans , Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.
- Published
- 2021
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