1. Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans
- Author
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Rivera-Paredez, Berenice, Macías-Kauffer, Luis, Fernandez-Lopez, Juan Carlos, Villalobos-Comparán, Marisela, Martinez-Aguilar, Mayeli M, de la Cruz-Montoya, Aldo, Ramírez-Salazar, Eric G, Villamil-Ramírez, Hugo, Quiterio, Manuel, Ramírez-Palacios, Paula, Romero-Hidalgo, Sandra, Villarreal-Molina, María Teresa, Denova-Gutiérrez, Edgar, Flores, Yvonne N, Canizales-Quinteros, Samuel, Salmerón, Jorge, and Velázquez-Cruz, Rafael
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Genetics ,Obesity ,Prevention ,Nutrition ,Aetiology ,2.1 Biological and endogenous factors ,ATP Binding Cassette Transporter ,Subfamily G ,Member 2 ,Adolescent ,Adult ,Child ,Female ,Genome-Wide Association Study ,Glucose Transport Proteins ,Facilitative ,Humans ,Hyperuricemia ,Male ,Mexico ,Middle Aged ,Neoplasm Proteins ,Polymorphism ,Single Nucleotide ,Uric Acid ,Young Adult ,Genome-Wide Association Studies ,polymorphisms single nucleotide ,ABCG2 gene ,SLC2A9 gene ,Mexican population ,Food Sciences ,Nutrition and Dietetics ,Clinical sciences ,Nutrition and dietetics ,Public health - Abstract
Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to identify factors associated with serum uric acid levels and hyperuricemia in Mexicans. A pilot Genome-wide association study GWAS was performed in a subgroup of participants (n = 411) from the Health Workers Cohort Study (HWCS). Single nucleotide polymorphisms (SNPs) associated with serum uric acid levels were validated in all the HWCS participants (n = 1939) and replicated in independent children (n = 1080) and adult (n = 1073) case-control studies. The meta-analysis of the whole HWCS and replication samples identified three SLC2A9 SNPs: rs1014290 (p = 2.3 × 10-64), rs3775948 (p = 8.2 × 10-64) and rs11722228 (p = 1.1 × 10-17); and an ABCG2 missense SNP, rs2231142 (p = 1.0 × 10-18). Among the non-genetic factors identified, the visceral adiposity index, smoking, the metabolic syndrome and its components (waist circumference, blood pressure, glucose and hyperlipidemia) were associated with increased serum uric acid levels and hyperuricemia (p < 0.05). Among the female HWCS participants, the odds ratio for hyperuricemia was 1.24 (95% CI, 1.01-1.53) per unit increase in soft drink consumption. As reported in other studies, our findings indicate that diet, adiposity and genetic variation contribute to the elevated prevalence of hyperuricemia in Mexico.
- Published
- 2019