1. Use of an Extract of Annona muricata Linn to Prevent High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice
- Author
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Luana Silva Soares, Lidiani Figueiredo Santana, Ana Rita Coimbra Motta-Castro, Rita de Cássia Avellaneda Guimarães, Larissa Melo Bandeira, Flávio Macedo Alves, Claudia Andrea Lima Cardoso, Bernardo Bacelar de Faria, Anderson Fernandes da Silva, Karine de Cássia Freitas, Luciane Candeloro Portugal, Priscilla Cristovam Sampaio e Souza, and Sandramara Sasso
- Subjects
0301 basic medicine ,medicine.medical_specialty ,obesity ,graviola ,medicine.medical_treatment ,Adipose tissue ,lcsh:TX341-641 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Weight loss ,Adipocyte ,Internal medicine ,Medicine ,Annona muricata ,Nutrition and Dietetics ,biology ,Cholesterol ,business.industry ,Insulin ,Histology ,biology.organism_classification ,medicine.disease ,Obesity ,030104 developmental biology ,Endocrinology ,chemistry ,030220 oncology & carcinogenesis ,medicine.symptom ,weight loss ,business ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
Annona muricata Linn, commonly known as graviola, is one of the most popular plants used in Brazil for weight loss. The aim of this study is to evaluate the therapeutic effects of three different doses (50 mg/kg, 100 mg/kg, and 150 mg/kg) of aqueous graviola leaf extract (AGE) supplemented by oral gavage, on obese C57BL/6 mice. Food intake, body weight, an oral glucose tolerance test (OGTT), an insulin sensitivity test, quantification of adipose tissue cytokines, weight of fat pads, and serum biochemical and histological analyses of the liver, pancreas, and epididymal adipose tissue were measured. AGE had an anti-inflammatory effect by increasing IL-10 at doses of 50 and 100 mg/kg. Regarding the cholesterol profile, there was a significant decrease in LDL-cholesterol levels in the AGE 150 group, and VLDL-cholesterol and triglycerides in the AGE 100 and 150 groups. There was an increase in HDL cholesterol in the AGE 150 group. The extract was able to reduce the adipocyte area of the epididymal adipose tissue in the AGE 100 and 150 groups. According to the histological analysis of the liver and pancreas, no significant difference was found among the groups. There were no significant effects of AGE on OGTT and serum fasting glucose concentration. However, the extract was effective in improving glucose tolerance in the AGE 150 group.
- Published
- 2019